2006. DOLOR CRÒNIC. PROJECTES FINANÇATS

Dra Ber Christen

Dra María Amor Hurlé González

Dra Pilar Sánchez Blázquez

Tramullas M., Lantero A., Díaz A., Morchón N., Merino D., Villar A., Buscher D., Merino R., Hurlé JM., Izpisúa-Belmonte JC., Hurlé MA. BAMBI (bone morphogenetic protein and activin membranebound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. J Neurosci. (2010) Jan 27;30(4):1502-11.

Dr Antonio Ferrer Montiel

Dra Rosa Maria Planells Cases

Dr Angel Messeguer Peypoch

Camprubí-Robles M., Planells-Cases R. , Ferrer-Montiel A. Differential contribution of snare-dependent exocytosis to inflammatory potentiation of trpv1 in nociceptors. FASEB, J. 23, 3722-3733 (2009).

Viana F., Ferrer-Montiel A. TRPA1 modulators in preclinical development. Exp. Opin. Therap. Patents. 19, 1787-1799. (2009)

Planells-Cases R., Camprubí-Robles M., Ferrer-Montiel A. TRP Channel Trafficking. In TRP channels in health and disease implications for diagnosis and therapy. Ed., A. Szallasi: Nova Publishers. (in press) (2010)

Camprubí-Robles,M., Ferrer-Montiel A., Planells-Cases R. Contribution of ion channel trafficking to nociceptor sensitization. Open Pain Journal (in press) (2010)

Laínez S., Valente P., Ontoria l., García-Sanz N., Ferrer-Montiel A., Planells-Cases R GABAA receptor-associated protein (GABARAP) traffics TRPV1 receptors to the plasma membrane. FASEB J (in press) (2009)

Goswamil G., Kuhn J., Dina OA., Fernández-Ballester G., Ferrer-Montiel A., Levine JD., Hucha T. PKCE destabilizes microtubules through a channel-independent TRPVl pathway. J. Cel! Sci. (submitted) (2009)

Navarro A., Encinar JA., Prieto J., Gómez J., Fernández-Ballester G., Neira JL., Ferrer-Montiel, A. Snapin is an oligomeric natively-unfolded protein, which forms a "fuzzy", non-structured complex with SNAP-25. J. Biol. Chem. (submitted) (2010)

Cuesta-Garrote N., Calderin S., Valente P.., Camprubí-Robles M., Ferrer-Montiel A., Planells-Cases R. The interaction of CIP98 with TRPV1 modulates channel expression. J. Neurochemistry (in preparation) (2009)

Dr Jesús Giraldo Arjonilla

Dr Jean Philippe Pin

Dr Amadeu Llebaria Soldevila

Dr Joaquim Ariño Carmona

Brea J., Castro M., Giraldo J., López-Giménez JF., padín JF., Quintián F., Cadavid MI., Vilaró MT., Mengod G., Berg KA, Clarke WP., Vilardaga JP., Milligan G., Loza MI. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine (2A) receptor homodimers. Mol Pharmacol. 75(6) :1380-91 (2009)

Rovira X., Vivó M., Serra J., Roche D., Strange PG., Giraldo J. Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system. Br J Pharmacol. 156(1) :28-35 (2009)

Giraldo J. On the fitting of binding data when receptor dimerization is suspected. . Br J Pharmacol. 155(1) :17-23 (2008)

Dr José Gutiérrez Maldonado

Dr Mel Slater

Dra Cristina Botella Arbona

Herrero R., García-Palacios A., Vizcaíno Y., Castilla D., Botella, C. The use of virtual reality for the delivery of a behavior activation component in the treatment of fibromyalgia. 2010 World Congress ofBehavioral and Cognitive Therapies Lugar: Boston, Estados Unidos (2010) (accepted publication pending)

Slater M., et al. First person experience of body transfer in virtual reality. PLos ONE (accepted with minor changes), (2010).

Slater M., et al. Inducing Illusory Ownership of a Virtual Body. Frontiers in Neuroscience, (2009). 3(2): p. 214-220.

González-Franco M., et al. The Contribution of Real-Time Mirror Rejlections of Motor Actions on Virtual Body Ownership in an Immersive Virtual Environment in IEEE VR. (2010): Waltham, MA, US.

Gutiérrez-Maldonado J., Rangel-Gomez MV., Alsina-Jurnet I., Rus-Calafell M.. Development and application oftechnologically advanced methods, based on virtual reality, for attention-diversion, as adjunct analgesic techniques against chronic pain. Frontiers in Neuroengineering. Conference Abstract: Annual CyberTherapy and CyberPsychology 2009 conference. Verbania, doi: 1 0.3389/conf.neuro.14.2009 .06.041 (2009)

Gutiérrez-Maldonado J., Gutiérrez-Martínez O., Loreto-Quijada D., Nieto-Luna R. The use of virtual reality for coping with pain: an experimental test with healthy participants (submitted to pain)

Gutiérrez-Martínez O., Gutiérrez-Maldonado J., Loreto-Quijada D. The use ofvirtual reality for ahuman cIassical conditioning procedure. Annual CyberTherapy and CyberPsychology conference. Seoul (2010) (submitted)

Gutiérrez-Maldonado J., Gutiérrez-Martínez O., Loreto-Quijada D., Peñaloza-Salazar C., NietoLuna R.. Presence, lnvolvement and Efficacy ofa Virtual Reality Intervention on Pain. Annual CyberTherapy and CyberPsychology conference. Seoul (2010) (submitted)

Gutiérrez-Martínez O., Gutiérrez-Maldonado J., Cabas-Hoyos K., Loreto-Quijada D.. The ilIusion ofpresence influences VR distraction: effects on cold-pressor pain. Annual CyberTherapy and CyberPsychology conference. Seoul (2010) (submitted)

Gutiérrez-Maldonado J, Gutiérrez-Martínez O, Loreto-Quijada D & Nieto-Luna R. Modificación de la percepción de control del dolor mediante visualización virtual. (2010) (submitted)

Gutiérrez-Maldonado J, Loreto-Quijada D, Cabas-Hoyos K, Gutiérrez-Martínez O & FerrerGarcía M. Aplicaciones de la realidad virtual en el tratamiento cognitivo-conductual del dolor crónico. Congreso Internacional sobre avances en tratamientos psicológicos. (2010) (submitted)

Dr Alberto Lleó Bisa

Sereno L., Coma M., Agullo J., España J., Borrelli L., Sanchez M., Garcia-Alloza M., Guardia-Laguarta C., Santpere G., Puig B., Rodriguez M., Clarimon J., Lleo A., Bacskai B., Saura CA., Gomez-Isla M. Triflusal reduces dense-core plaque load and inflammatory changes, and improves cognition in a transgenic mouse model of alzheimer's disease. Washington, DC: Society for Neuroscience, 2008. Online

Dra Eva Martínez Cáceres

Grau-López L., Raïch D., Ramo-Tello C., Naranjo-Gómez M., Davalos A., Pujol-Borrell R., Borras FE., Martínez-Cáceres E. Myelin peptides in multiple sclerosis. Autoimmun Rev. 2009 Jul; 8(8):650-3. PMID: 19393199

Grau-López L., Raïch D., Naranjo-Gómez M., Ramo-Tello C., Dávalos A., Pujol-Borrell R., Borras FE., Martínez-Cáceres E. Specific proliferation to myelin peptides in patients with relapsing-remitting multiple sclerosis (submitted)

Grau-López L., Sierra S., Ramo-Tello C. Análisis del dolor en pacientes con esclerosis múltiple. Revista de Neurologia (submitted)

Dr Jordi Miró Martínez

Miró J. Fernández L., Fullana MA. (Comps.) Tractament psicológic del dolor crónic en nens i adolescents. CDSCR/TC09. Barcelona SCRITC (2009)

Miró J., Aliaga L., Baños JE., De Barutell C., Molet J., Rodríguez de la Serna A. (Eds.) Psicologia del dolor. Tratamiento del dolor. Teoría y Práctica (3a edició; pp. 33-36). Barcelona: Permanyer. (2009)

Miró J. El dolor crónico en los niños: un problema muy extendido, relativamente poco investigado, y a menudo infratratado. Cuadernos de Medicina (2009) Psicosomàtica y Psiquiatría de Enlace, 89-90, 9-12 (Editorial convidada).

Miró J., Castarlenas E., Huguet A. Evidence for the use of a numerical rating scale to assess the intensity of pediatric pain. European Journa/ of Pain, 13, 1089-1095. (2009)

Miró J., Huguet A. Pain-specific beliefs predict pain intensity and pain status in children: uselfulness of the Pediatric version of the Survey of Pain Attitudes. Segona revisió. (Submitted - Works in progress)

Miró J., Huguet A, Nieto R. Pain catastrophizing predicts pain intensity and pain-related disability in children. In progress. (Submitted - Works in progress)

Miró J., Olivé R., Huguet A. Pain, disability, and quality of life in children following surgery. In progress. (Submitted - Works in progress)

Miró J., Castarlenas E., Huguet A. Evidence for the use of a numerical rating scale to assess the intensity of pediatric pain. 6th Congress of the European Federation of IASP Chapters; European Journal of Pain, 13, S225 (2009)

Miró J., Huguet A. A Catalan adaptation of the pediatric version of the Survery of Pain Attitudes: a validation study with a schoolchildren sample. 6th Congress of the European Federation of IASP Chapters; European Journal of Pain, 13, S22. (2009)

Miró J., Huguet A. A one-year longitudinal study of chronic pain in children and adolescents. American Pain Society (APS) 28th Annual Scientific Meeting; Journal of Pain, 10, S5 (2009).

Miró J., Olivé R., Huguet A. Pain, disability, and quality of life in children following surgery. American Pain Society (APS) 28th Annual Scientific Meeting; Journal of Pain, 10, S7 (2009).

Dr Olga Pol Rigau

Leánez S., Hervera A., Poi O. Peripheral antinociceptive effects of IJ- and ó-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain. European Journal of Pharmacology, 602: 41-49, 2009

Torres I., Leánez S., Pol O. The involvement of nitric oxide in the peripheral antinociceptive effects of opioids during chronic inflammatory pain. 15th Internationallnflammation Research Association Virginia, USA, 2008. Conference Inflammation Research, 57: S104, Suppl. 2

Hervera A, Leánez S, Negrete R, Pol O. The peripheral administration of a nitric oxide donor potentiates the local antinociceptive effects of a DOR agonist during chronic inflammatory pain in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 380: 349-352, 2009

Hervera A, Negrete R, Leánez S, Pol O. Lack of mechanical and thermal allodynia, and thermal hyperalgesia induced by peripheral neuopathic pain in NOS2 knockout mice. 4th International Conference on cGMP BMC Pharmacology, 9 (Suppl 1): 24 Regensburg, Germany, 2009

Negrete R, Martín-Campos J, Hervera A, Leánez S, Poi O. Expresión de receptores opioides IJ y ó en los ganglios de la raíz dorsal y médula espinal de ratones deficientes para NOS1 y NOS2 expuestos a un dolor inflamatorio XIII Congreso de la Sociedad Española de Neurociencia Libro de Abstracts: 401: 212 Tarragona, Spain, 2009

Hervera A, Negrete R, Leánez S, Pol O. Papel del óxido nítrico sintetizado por las enzimas óxido nítrico sintasa neuronal e inducible sobre el desarrollo y la expresión de un dolor neuropático periférico en ratón XI" Congreso de la So~iedad Española de Neurociencia Libro de Abstracts: 402: 212 Tarragona, Spain, 2009

Negrete R, Martín-Campos J, Hervera A, Leánez S, Pol O. The expression of IJ- and ó-opioid receptors in the dorsal root ganglia and spinal cord of NOS1 and NOS2 knockout mice exposed to inflammatory pain Neuropharmacology Conference 2009-Neuropeptides Abstract Viewerlltinerary Planner: P1.3.06 Chicago, USA, 2009

Hervera A, Negrete R, Leánez S, Pol O.The crucial role of nitric oxide synthesized by NOS2 in the development and maintenance of peripheral neuropathic pain in mice 38nd Annual Meeting of Society for Neuroscience Abstract Viewer/ltinerary Planner: 857.9/ Y16 Chicago, USA, 2009

Negrete R, Martín-Campos J, Hervera A, Leánez S, Pol O. Expresión de receptores opioides IJ y o en los ganglios de la raíz dorsal y médula espinal de ratones deficientes para las enzimas óxido nítrico sintasa neuronal o inducible expuestos a un dolor inflamatorio 111 Jornadas Científicas Institut de Neurociéncies-UAB Libro de Abstracts: P7. 2 Barcelona, Spain, 2009

Hervera A, Negrete R, Leánez S, Pol O. Papel del óxido nítrico sintetizado por las enzimas óxido nítrico sintasa neuronal e inducible sobre el desarrollo y la expresión de un dolor neuropático periférico en ratón 111 Jornadas Científicas Institut de Neurociéncies-UAB Libro de Abstracts: P7.1: 13 Barcelona, Spain, 2009

Dr Margarita Puig Riera de Conías

Cabañero D., Célérier E., García-Nogales P., Mata M., Roques B., Maldonado R., Puig MM. The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opio id receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain 141: 88-96.

Campillo A., González-Cuello A., Cabañero D., García-Nogales P., Romero A., Milanés MV., Laorden ML., Puig MM. Increased Spinal Dynorphin Levels, and pERK1l2 and c-Fos Immunoreactivity after Surgery under Remifentanil Anaesthesia in Mice. Molecular Pharmacology (2010), 77:185-94.

Cabañero D., Campillo A., Celerier E., Romero A., Puig MM. Pronociceptive Effects of Remifentanil in a Mouse Model of Post-Surgical Pain: Effect of a Second Surgery. Anesthesiology (2009); 111: 1334-45.

Romero A., Miranda HF., Puig M. Analysis of opioid-opioid combinations according to the Í70ciceptive stimulus in mice. Pharmacological Research (in revision).

Romero A., Miranda HF., Puig MM. Antinociceptive effects of fentanyl, tramadol and their combination, in morphine-tolerant mice. Eur J. Pharmacol (in revision).

Cabañero D., Campillo A., .Célérier E., Romero A., Puig MM: A second surgery performed under remifentanil anaesthesia increases the extent and duration of post-operative hyperalgesia in mice. Pain in Europe VI: 6th Congress of the European Federation of IASP@ Chapters (EFIC). Lisbon, Portugal, September 9-12,2009. EJP 13, Supplement 1, (2009). S85, 272.

Campillo A., Cabañero D., García-Nogales P., Romero A., Puig MM.: Characterization of kappa opioid receptor and prodynorphin/dynorphin expression in dorsal root ganglia, in a murine model of postoperative pain. Pain in Europe VI: 6th Congress of the European Federation of IASP@ Chapters (EFIC). Lisbon, Portugal, September 9-12,. EJP 13, Supplement 1, (2009). S85, 273.

Cabañero D., Campillo A., Célérier E., Romero A., Puig MM.: Hiperalgesia postoperatoria después de una segunda cirugía realizada bajo anestesia con remifentanilo. XIII Congreso de la Sociedad Española de Neurociencia. Del 16 al19 de Septiembre, Tarragona, (2009). Libro de resúmenes pp.155; P219.

Campillo A., González-Cuello A., Cabañero D., Romero A., Milanés MV., Laorden ML., Puiq MM.: La administración intraoperatoria de remifentanilo en el ratón induce la expresión de ERK1/2, FOS y dinorfina en la médula espina!. XIII Congreso de la Sociedad Española de Neurociencia. Del 16 al 19 de Septiembre, Tarragona, (2009). Libro de resúmenes pp.155; P220.

Romero A., Miranda HF., Dürsteler C. Puig MM. Las características del estímulo nociceptivo modifican el tipo de interacción entre el tramadol y la morfina. XIII Congreo de la Sociedad Española de Neurociencia. Del 16 al 19 de Septiembre Tarragona (2009). Libro de resúmenes pp. 154; P218.

Dr Manuel Ramos Casals

Ramos-Casals M., Srito-Zerón P., Perez-De-Lis M., Jimenez I., Slanco MJ., Sove A., Soto MJ., Akasbi M., Diaz C., Sentís J., Siso A. Sjogren Syndrome or Sjogren Disease? The Histological and Immunological Sias Caused by the 2002 Criteria. Clin Rev Allergy Immunol. (2009). (Epub ahead of print)

Marcos M., Alvarez F., Srito-Zerón P., Sove A., Perez-De-Lis M., Diaz-Lagares C., Sanchez-Tapias JM., Ramos-Casals M. Chronic hepatitis S 'virus infection in Sjogren's syndrome. Prevalence and clinical significance in 603 patients. Autoimmun Rev. 2009;8:616-20. Epub (2009)

Ramos-Casals M., Srito-Zerón P., Soria N., Nardi N., Vargas A., Muñoz S., Sové A., Suárez S., Lozano F. Mannose-binding lectin-Iow genotypes are associated with milder systemic and immunological disease expression in primary Sjogren's syndrome. Rheumatology (Oxford). (2009);48:65-9.

Selenguer R., Sisó A., Ramos-Casals M. Clasificación de la fibromialgia. Revisión sistematica de la literatura. Reumatología Clínica (2009) (in press).

Selenguer R., Sisó A., Ramos-Casals M. . Utilidad de la clasificación de la fibromialgia. JANO (2008);1713:28-32.

Literatura científica

Dr Eduardo Soriano García

Cotrufo T., Pérez-Brangulí F., Muhaisen A., Andrés RM., Baeriswyl T., Ros O. Tarragó, Pascual M., Ureña J., Del Rio JA., Comella JX., Giralt E., Blasi J., Stoeckli E., Soriano E. The SNARE protein Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction ofaxons and migrating cells (in revision)

Dr Gregorio Valencia Parera

Dr Raquel E. Rodríguez Rodríguez

Dr Jesús Jiménez Barbero

Dr Núria Boada Centeno

Arsequell G., Salvatella M., Valencia G., Fernandez-Mayoralas A., Fontanella M., Venturi C., Jiménez-Barbero J., Marrón E., Rodríguez RE. Synthesis, conformational and biological characterization ofa sugar derivative ofmorphine which is a potent, long lasting and non tolerant antinociceptive. J. Med. Chem. 52(9) 2656-2666 (2009)

Rosa M., Arsequell G., Valencia G., Centeno NB., Pinto M., Rougeot C . Effect of halogen bonding on the inhibitory activity of new ha/ogenated opiorphin analogs. (2009) (in preparation)

Dr Josep Valls Solé

Dr Josep M. Tormos Muñoz

Dr Paul Verschure

Kumru H., Vidal J., Kofler M., Portell E., Valls-Solé J. Alterations in excitatory and inhibitory brainstem intemeuronal circuits after severe spinal cord injury. J Neurotrauma (2010) Apr;27( 4):721-8.

Kumru H., Kofler M., Valls-Solé J. Portell E., Vidal J. Brainstem reflexes are enhanced following severe spinal cord injury and reduced by continuous intrathecal baclofen. Neurorehabil Neural Repair. (2009) Nov;23(9):921-7. Epub 2009 May 19

Kumru H., Murillo N., Vidal Samso J., Valls-Sole J., Edwards D., Pelayo R., Valero-Cabre A., Tormos JM., Pascual-Leone A. Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury. Neurorehabil Neural Repair. (2010) Jan 6. (Epub ahead of print) PubMed PMID: 20053952.

Casanova-Molla J.,Grau-Junyent JM., Morales M., Valls-Solé J. On the relationship between nociceptive evoked potentials and intraepidermal nerve fibre density in sensory polyneuropathies. Joumal ofNeurology, Neurosurgery and Psychiatry (submitted)

Valls-Solé J, Castellote JM., Kofler M., Casanova-Molla J., Alvarez-Blanco S., Kumru H., Schestatsky P. SubjeCtive awareness of sensation to radiant and contact warmth and heat pain stimuli. Joumal of Neurology (submitted)

Soler MO., Kumru H., Pelayo R., Vidal J., Tormos JM., Navarro X., Pascual-Leone A. Feeling the legs after complete spinal cord injury: Referred sensations and neuropathic pain Reunió Anual de la Societat Espanyola de Neurologia (2008) (revision in process in Pain).

Kumru H., Opisso E., Valls-Solé J., Kofler M. The effect of a prepulse stimulus on the EMG rebound following the cutaneous silent periodo J Physiol. (2009) Feb 1 ;587 (Pt 3):587-95.

Kumru H., Vidal J., Perez M., Schestatsky P., Valls-Solé J. Sympathetic Skin Responses Evoked by Oifferent Stimuli Modalities in Spinal Cord Injury Patients. Neurorehabil Neural Repair. (2009) Jan 6. PubMed PMIO: 19126837