MALALTIES RESPIRATÒRIES. 2003. PROJECTES FINANÇATS

Dr Josep M. Antó Boqué

Balcells E., Garcia-Aymerich J., Antó JM. Estudio de la actividad física habitual mediante acelerómetro y cuestionario en pacientes con EPOC. Prueba piloto. Evaluation of Regular Physical Activity in COPD Patients with an Accelerometer and a Questionnaire: A Pilot Study. Arch Bronconeumol 2007; 43(9): 524-5

Garcia-Aymerich J., Gómez FP., Antó JM., on behalf of the PAC-COPD Research Study Group. Phenotype characterisation and course of chronic obstructive pulmonary disease (COPD) in the PAC-COPD Study: design and methods. Arch Bronconeumol 2009;45(1):4-11

Garcia-Aymerich J., Agustí A., Barberà JA., Belda J., Farrero E., Ferrer A., Ferrer J., Galdiz JB., Gea J., Gómez FP., Monsó E., Morera J., Roca J., Sauleda J., Antó JM., on behalf of the PAC-COPD Study Group. The phenotypic heterogeneity of chronic obstructive pulmonary disease (COPD). Arch Bronconeumol 2009 (in press)

Garcia-Aymerich J., Serra I., Gómez FP., Farrero E., Balcells E., Rodríguez DA., de Batlle J., Gimeno E., Donaire-Gonzalez D., Orozco-Levi M., Sauleda J., Gea J., Rodriguez-Roisin R., Roca J., Agustí AG., Antó JM., and the PAC-COPD Study Group. Physical activity and clinical and functional status in chronic obstructive pulmonary disease (COPD). Chest 2009 (in press)

Antó JM., Gea J., Gómez FP., Rodríguez E., Marin A., Ferrer A., de Batlle J., Farrero E., Benet M., Orozco-Levi M., Ferrer J., Agustí AG., Gáldiz JB., Belda J., Garcia-Aymerich J., Balcells E. Characteristics of patients admitted for the first time for COPD exacerbation. Respir Med (in revision 2009)

De Batlle J., Romieu I., Antó JM., Mendez M., Rodríguez E., Balcells E., Ferrer A., Gea J., Rodriguez-Roisin R., Garcia-Aymerich J., and the PAC-COPD Study Group. Dietary habits of firstly admitted Mediterranean COPD patients (accepted publication pending 2008)

Prevalence and determinants of systemic inflammation in chronic obstructive pulmonary disease (sent to publication)

Unexpected high prevalence of left ventricular cardiopathy in patients with chronic obstructive pulmonary disease (in preparation)

Exercise tolerance in copd patients: relationships with body mass distribution and systemic inflammation (in preparation)

Circulating auto-antibodies in patients with chronic obstructive pulmonary disease (in preparation)

Dr Josep Maria Argilés Huguet

Argilés JM., Olivan M. Understanding the molecular mechanisms responsible for skeletal muscle wasting in COPD patients: therapeutic implications. International Journal of Molecular Medicine 22: S12 (2008)

Olivan M., Busquets S., López-Soriano FJ., Argilés JM. Proteolytic response in skeletal muscle of COPD patients: possible mediators (in preparation)

Dr Joan Albert Barberà Mir

Diez M., Barberà JA., Ferrer E., Fernandez-Lloris R., Pizarro S., Roca J., Peinado VI. Plasticity of CD133(+) cells: Role in pulmonary vascular remodeling. Cardiovasc Res 2007;76:517-527

Peinado VI., Ramirez J., Roca J., Rodriguez-Roisin R., Barbera JA. Identification of vascular progenitor cells in pulmonary arteries of patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2006;34:257-263

Diez M., Peinado V., Ferrer E., Ramirez J., Roca J., Rodriguez-Roisin R., Barberà JA. Plasticity of vascular progenitor cells: implications in pulmonary vascular remodeling in COPD. Eur Respir J 2006;28:803s

Ferrer E., Peinado VI., Diez M., Ramírez J., Roca J., Rodríguez-Roisín R., Barberà J.A. Efecto de 6 meses de exposición al humo de tabaco sobre la función endotelial de las arterias pulmonares y sistémicas en un modelo de cobaya. Arch Bronconeumol 2006;42(supl.1):11

Peinado VI., Diez M., Ferrer E., Ramirez J., Roca J, Rodriguez-Roisin R., Barbera JA. Circulating CD133+ Cells Differentiate into Smooth Muscle Cells in the Intima of Human Pulmonary Arteries. Am J Respir Crit Care Med 2007;175:A501

Pizarro S., Diez M., Peinado VI., Torralba Y., Delgado V., Petriz J., Sitges M., Marín P., Melgosa MT., Roca J., Barberà JA. Circulating endothelial progenitor cells in COPD: effect of pulmonary hypertension. Eur Respir J 2007;30:57s

Ferrer E., Peinado VI., Díez M., Ramírez J., Rodriguez-Roisin R., Barberà JA. Study of the effects of chronic exposure to cigarette smoke in the rat. Eur Respir J 2007;30:605s

Ferrer E., Peinado VI., Díez M., Ramírez J., Barberà JA. Efectos de la exposición crónica al humo de tabaco en la rata. Arch Bronconeumol 2007;43(supl.1):14

Díez M., Barberà JA., Ferrer E., Ramírez J., Peinado VI. Plasticidad de las células progenitoras vasculares circulantes: papel en el remodelado vascular pulmonar en la EPOC. Arch Bronconeumol 2007;43(supl.1):20

Díez M., Pizarro S., Peinado VI., Gimeno E., Torralba Y., Sitges M., Pétriz J., Marín P., Roca J., Barberà JA. Efectos del ejercicio agudo y del entrenamiento en las células progenitoras endoteliales circulantes en la EPOC. Arch Bronconeumol 2007;43(supl.1):46

Pizarro S., Díez M., Peinado VI., Delgado V., Torralba Y., Melgosa MT., Pétriz J., Sitges M., Marín P., Rodríguez-Roisin R., Barberà JA. Células progenitoras endoteliales circulantes en fumadores y pacientes con EPOC. Arch Bronconeumol 2007;43(supl.1):13

Peinado VI., Pizarro S., Diez M., Ferrer E., Sitges M., Molins L., Catalan M., Rodriguez-Roisin R., Roca J, Barbera JA. Assessment of endothelial function in systemic and pulmonary arteries in COPD. Am J Resp Crit Care Med 2008;177:A443

Pizarro S., Diez M., Peinado VI., Torralba Y., Petriz J., Sitges M., Marin P., Rodríguez-Roisin R., Roca J., Barberà JA. Reduction of circulating endothelial progenitor cells in chronic obstructive pulmonary disease (COPD). Am J Resp Crit Care Med 2008;177:A772

Diez M., Pizarro S., Peinado VI., Gimeno E., Ferrer E., Torralba Y., Sitges M., Petriz J., Marin P., Roca J., Barberà JA. Effects of acute exercise and exercise training on circulating endothelial progenitor cells in COPD. Am J Resp Crit Care 2008;177:A772

Pizarro S., Diez M., Peinado VI., Ferrer E., Torralba Y., Sitges M., Molins L., Macchiarini P., Blanco I., Rodríguez-Roisin R., Roca J., Barberà JA. Endothelial function and vascular biomarkers in COPD. Eur Respir J 2008;32:162s

Portillo K., Torralba Y., Blanco I., Pizarro S., Gómez F., Rodríguez-Roisin R., Roca J. y Barberá JA. Características de la hemodinámica pulmonar en la enfermedad pulmonar obstructiva crónica (EPOC). Arch Bronconeumol 2008;44(supl.1):15

Pizarro S., Díez M., Peinado VI., Ferrer E., Torralba Y., Sitges M., Molins L., Catalán M., Roca J., Rodríguez-Roisin R. y Barberà JA. Estudio de la función endotelial de las arterias sistémicas y pulmonares en la enfermedad pulmonar obstructiva crónica (EPOC). Arch Bronconeumol 2008;44(supl.1):19

Dr Josep A. Capdevila Morell

Boixeda R., Rabella N., Sauca G., Delgado M., Martínez-Costa X., Mauri M., Vicente V., Palomera E., Capdevila JA. Importancia de la infección vírica en la exacerbación de la enfermedad obstructiva crónica. XIII Congreso de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, Madrid, 11-14 de Maig de 2008. Enferm Infecc Microbiol Clin 2008; 26 (Supl 4):52

Dr Pere Casan Clarà

Dr Pere Riu Costa

De Lema B., Casan P., Riu P. Tomografía por Impedancia eléctrica. Estandarización del procedimiento para su aplicación en neumología. Arch Bronconeumol 2006;42:299-301

Balleza M., Fornos J., Calaf N., Feixas T., González M., Anton D., Riu PJ., Casan P. Seguimiento del patrón ventilatorio en reposo mediante tomografía por impedancia eléctrica. Arch Bronconeumol 2007;43 (6):300-3

Balleza M., Fornos J., Calaf N., Feixas T., González M., Anton D., Riu PJ., Casan P. Ventilatory Pattern monitoring with Electrical Impedance Tomography (EIT). Validation for Healthy Subjects. IFMBE Proceedings. 2007;17:572-575

Anton D., Balleza M., Fornos J., Kos B, Casan P., Riu PJ. A Compact EIT System for Ventilation Monitoring in COPD Patients. IFMBE Proceedings vol. 17:564-7. XIII ICEBI, Graz, Austria, August 2007

Balleza M., Fornos J., Calaf N., Feixas T., González M., Antón D., Riu PJ., Casan P. Monitorización del patrón ventilatorio mediante tomografia por impedancia eléctrica (TIE) en personas sanas: calibración del tomógrafo a partir de variables antropométricas (second revision Annals of Biomedical Engineering. ABME1667)

Balleza M.; Feixas T.; Calaf N.; González M.; Antón D.; Riu PJ., Casan P. Ventilatory pattern monitoring by electrical impedance tomography (EIT) in chronic obstructive pulmonary disease (COPD) patients. IFMBE Proceedings. Vol 22. 740-3, 2008

Balleza M., Calaf N., Feixas T., González M., Antón D., Riu PJ., Casan P. Medición del Patrón Ventilatorio (PV) mediante Tomografía por Impedancia Eléctrica (TIE) en pacientes con EPOC. Archivos de Bronconeumología (accepted publication pending 2009)

Dr  Josefina Casas Brugulat

Dr Antonio Delgado Cirilo

Dr Antonio Gómez Muñoz

Delgado A., Llebaria A.,  Abad J. L., Fabriás G., Casas  J. Chemical approaches to sphingolipid functions. In: Sphingolipids and Cell Funtion (Albi, E. Ed) Research Signpost, 2006, Kerala, India.1-52

Delgado A., Llebaria A.,  Abad J. L., Fabriás G., Casas  J.  Inhibitors of Sphingolipid Metabolism Enzymes. Biochim. Biophys. Acta Biomembranes 2006, 1758, 1957-1977

Bedia C. ,  Garcia V., Levade T. , Fabrias  G, Casas J. Synthesis of a novel ceramide analog and its use in a high-throughput fluorogenic assay for ceramidases. ChemBioChem, 2007, accepted

Grijalvo S.,  Bedia C.,  Triola G., Llebaria A. ,  Teixido J.,  Rabal O., Levade T.,  Delgado A., Fabrias G., Casas J. Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids. 2006, 144, 69-84

Villorbina G, Canals D, Carde L, Grijalvo S, Pascual R, Rabal O, Teixido J, Fabrias G, Llebaria A,  Delgado A., Casas J. Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells. Bioorg Med Chem. 2007, 15, 50-62

Canals D, Villorbina G, Grijalvo S, Delgado A, Llebaria A, Fabrias G, Casas J. Sphingolipid analogs: searching new drugs against COPD. Naunyn-Schmiedeberg's Arch Pharmacol, 2007, 374, 337

Gómez-Muñoz. A. Ceramide-1-phosphate/ceramide: a switch between life and death Biochim. Biophys. Acta - Biomembranes 2006 1758, 2049-2056

Delgado A., Casas J., Llebaria A., Abad JL., Fabriàs G. Chemical Tools to Investigate Sphingolipid Metabolism and Functions. Chem MedChem. 2007 2(5):580-606

Grijalvo S., Llebaria,A., Delgado A. A straightforward acces to simplified sphingosine-1-phosphate analogues. Synthetic Commun 2007, 37, 16, 2737-2751

Bedia C., Canals D., Matabosch X., Harrak Y., Casas J.,Llebaria A., Delgado A., Fabriàs G. Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides. Chem Phys Lipids. 2008, 156(1-2):33-40

Gangoiti P., Granado MH., Arana L., Ouro A., Gómez-Muñoz A. Involvement of Nitric oxide in the promotion of cell survival by ceramide 1-phosphate. FEBS Lett. 2008 ;582(15):2263-9

Grijalvo S., Matabosch,X., Llebaria A., Delgado A. A Straightforward Protocol for the Solution-Phase Parallel Synthesis of Ceramide Analogues. Eur. J. Org. Chem. 2008, 2008, 150-155

Canals D., Mormeneo D., Fabriàs G., Casas J., Llebaria A., Delgado A. Synthesis and biological properties of pachastrissamine (Jaspine B) and diastereomeric jaspines. Bioorg Med Chem. 2009, 17(1):235-41

Granado MH., Gangoiti P., Ouro A., Arana L., González M., Trueba M., Gómez-Muñoz A. Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor. Cell Signal. 2009, 21(3):405-12

Canals D., Grijalvo S., Fabrias G., Llebaria A., Casas J., Delgado A. Synthesis of a combinatorial library of ceramide-1-phosphate analogues and its activity in human alveolar epithelial cells (in preparation)

Granado MH., Gangoiti P., Grijalvo S., Sisa M., Delgado A., Gómez-Muñoz A. Anti-inflammatory action of the C1P analogues in alveolar macrophages: inhibition of acid sphingomyelinase acvtivity (in preparation)

Dr Joan Artur Caylà Buqueras

Borrell S., Español M., Orcau A., Tudó G., March F., Caylà JA. et al. Factors associated with differences between conventional contact tracing and molecular epidemiology in study of tuberculosis transmisión and análisis in the city of Barcelona, Spain. J of Clin Microbiol 2009;47(1):198-204

Borrell S., Español M., Orcau A., Tudó G., March F., Caylà JA. et al. Tuberculosis transmission patterns among Spanish and foreign-born populations in the city of Barcelona. Clin Microbiol Infect (in press)

Borrell S., Thorne N., Español M., Mortimer C., Orcau A. et al. Comparison of Four colour IS6110-fAFLP with the classic IS6110-RFLP on the ability to detect recent transmission in the city of Barcelona, Spain. Tuberculosis Journal (in press)

Ospina JE., Orcau A., Millet JP., Sánchez F., Rius C., Casals M., Caylà JA. and the Barcelona Tuberculosis and Immigration Working Group. Effectiveness of Community Health Workers for the control of tuberculosis in a city with recent and massive immigration (sent to publication The Journal of Epidemiology and Community Health)

Carnicer-Pont D., Casals M., Jansà JM., Caylà JA., Sanchez P., Vidal R., Martinez Roig A., Altet N., Orcau A., Rius C. Tuberculosis transmission to children: Is there a difference between immigrants and autochthonous households? (sent to publication Pediatrics)

Dr  José Antonio Domínguez Benítez

Andreo F., Lores L., Prat C., Ruiz J., Blanco S. , Corbella A., Rivelo R., Torres P., Ausina V., Domínguez J. Evaluation of procalcitonin (PCT) and neopterin levels in acute exacerbations of COPO 15th European Respiratory Society Annual Congress. European Respiratory Journal. 2005. 14(S):227. Copenhaguen

Prat C., Blanco S., Vilaplana C., Rivelo R., Latorre I., Matas L., Giménez M., Ramil C., Ruiz-Manzano J., Ausina V., Domínguez J.  Usefulness of procalcitonin and neopterin measurement in the management of exacerbation in chronic obstructive pulmonary diseases. 15th European Congress of Clinical Microbiology and Infectious Diseases. Clinical Microbiology and Infection. 2005. 11 (S2):690. Copenhagen

Andreo F., Ruiz-Manzano J., Prat C., Lores L., Blanco S., Corbella A., Ribo F.., Ausina V., Domínguez J. Utilidad de la determinación de procalcitonina y neopterina en la orientación diagnóstica y terapéutica en las exacerbaciones infecciosas de la enfermedad obstructiva crónica. XXXVIII Congreso de la Sociedad Española de Neumología y Cirugía Torácica. Archivos de Bronconeumología. 2005; 41 :56 (2005)

Prat C., Domínguez J., Andreo F., Blanco S., Pallarés MA., Cuchillo F., Ramil C., Ruiz-Manzano J., Ausina V. Correlation of procalcitonin and neopterin with etiology and severity of pneumonia. Journal of Infection. 2006. 52:169-177

Prat C., Lacoma A., Domínguez J., Papassotiriou J., Morgenthaler NG., Andreo F., Tudela P., Ruiz-Manzano J., Ausina V. Midregional Pro-Atrial natriuretic peptide as a prognostic marker in pneumonia. Journal of Infection. 2007. 55:400-407

Dr Esteve Fernández Muñoz

Dr Manel Nebot Adell

Dr Josep A. Pascual Esteban

Ariza C., Schiaffino A., Pascual JA., Twose J., Nebot M., Fernandez E. Exposición al humo de tabaco y concentración de cotinina en saliva en una muestra de escolares de Barcelona. Medicina Clínica (Barc) (in press)

Martín-Pujol A., Schiaffino A., Moncada A., Rajmil L., López MJ., Ariza C., Saltó S., Pascual JA., Bosque M., Nebot M., Fernández E., Grupo Respir.Net. Asociación entre consumo de tabaco, tabaquismo pasivo, asma y sibilancias en escolares (sent to publication)

Martínez Ferrer MS., Juárez Martínez O., Nebot Adell M., Grupo Respir.Net. Prevención de la exposición al humo ambiental de tabaco entre los niños: una revisión de la efectividad de las intervenciones (sent to publication)

Fernández E., Blanch C., Schiaffino A., Moncada A., Rajmil L., López MJ., Ariza C., Saltó S., Martín-Pujol A., Martínez-Sánchez JM., Pascual JA., Bosque M., Nebot M., Respir.Net Group. Design and baseline characteristics of a randomized controlled school-based trial to prevent exposure to second-hand smoke in adolescents (in preparation)

Blanch C., Martínez-Sánchez JM., Schiaffino A., Moncada A., Rajmil L., López MJ., Ariza C., Saltó S., Martín-Pujol A., Pascual JA., Bosque M., Nebot M., Fernández E., Respir.Net Group. The effectiveness of a multilevel (individual, class/school and family) intervention to reduce exposure to second-hand smoke in adolescents (in preparation)

Blanch C., Martínez-Sánchez JM., López MJ., Ariza C., Saltó S., Martín-Pujol A., Schiaffino A., Moncada A., Rajmil L., Pascual JA., Bosque M., Nebot M., Fernández E., Respir.Net Group. Validitaty of a self-reported questionnaire to assess exposure to second-hand smoke against hair nicotine measurement (in preparation)

Dr Jordi Gratacós Masmitjà

Gallego M., Berlanga E., Larrosa M. Osteoporosis in Chronic Obstructive Pulmonary Disease. Clin Pulm Med 2007; 14: 191-196

Dr Esther Julián Gómez

Dr Carles Alonso Tarrés

Rodríguez-Güell E., Agustí G., Corominas M., Cardona PJ., Luquin M., and Julián E. Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall IFN-? responses to M. vaccae cell-wall skeleton (2008). Clinical Vaccine Immunology. 15(5):893-6

Rodríguez-Güell E., Agustí G., Corominas M., Luquin M, and Julián E. Impaired IFN-? response to Mycobacterium vaccae antigens in cavitary pulmonary tuberculosis. (2008) Clinical Vaccine Immunology. 15(9): 1485-8

Rodríguez-Güell E., Alonso C., del Val Romero B., Clivillé R., Secanella SP., Roura-Mir C., Cañete C., Navarro A., de Gispert FX., Luquin M., and Julián E. Increasing kinetic of IFN-? production by mycolic acids-induced CD1-restricted T cells in tuberculosis patients (in preparation)

Rodríguez-Güell E., Luquin M., del Val Romero B., Clivillé R., Cañete C., Navarro A., de Gispert FX., Julián E, and Alonso C. Different humoral response against mycolic acids and cord factor antigen in tuberculous patients (in preparation)

Dr Manolis Kogevinas

Castro-Giner F., Kauffmann F., de Cid R., Kogevinas M. Gene-environment interactions in asthma. Occup. Environ. Med. 2006;63;776-786

Castro-Giner F., Kogevinas M., Ma¨chler M., de Cid R., Van Steen K, Imboden M., Schindler C., Berger W., Gonzalez JR., Franklin KA., Janson C., Jarvis D., Omenaas E., Burney P., Rochat T., Estivill X., Anto JM., Wjst M. and Probst-Hensch NM. TNFA -308G>A in two international population-based cohorts and risk of asthma. Eur Respir J 2008; 32: 350-61

Kauffmann F., Castro-Giner F., Smit LAM., Nadif R., Kogevinas M. Gene-environment interactions in occupational asthma. In T. Sigsgaard/D. Heederik (Editors). Occupational Asthma. Progress in Inflammation Research, Birkhäuser Verlag AG (in press 2009)

Castro-Giner F., Kogevinas M., Imboden M., de Cid R., Jarvis D., Mächler M., Berger W., Burney P., Franklin KA., Gonzalez JR., Heinrich J., Janson C., Omenaas E., Pin I., Rochat T., Sunyer J., Wjst M., Antó JM., Estivill X., Probst-Hensch NM. Joint effect of obesity and TNFA variability on asthma: two international cohort studies. Eur Respir J. 2009 Feb 5 (epub ahead of print)

Castro-Giner F., Bustamante M., González JR., Kogevinas M., Jarvis D., Heinrich J., Antó JM., Wjst M., Estivill X., de Cid R. A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS) (submitted BMC Medical Genetics 2009)

Castro-Giner F., de Cid R., Gonzalez JR., Jarvis D., Janson C., Wjst M., Antó JM., Estivill X., Kogevinas M. Positionally cloned genes and age specific effects in asthma and atopy: an international population-based cohort study (ECRHS) (submitted AJRCCM 2009)

Castro-Giner F., Künzli N., Jacquemin B., Forsberg B., de Cid R., Sunyer J., Jarvis D., Briggs D., Vienneau D., Norback D., González JR., Guerra S., Janson C., Antó JM., Wjst M., Heinrich J., Estivill X., Kogevinas M. Traffic related air pollution, oxidative stress genes and asthma (ECHRS) (under revision, Environ Health Persp 2009)

Dr Concepción Larraz Gimeno

Gómez A., Román M.,  Esteva M., Mir I., Thomás V., Ripio J., Miranda Pacheco E.Z., Macho A. Larraz C.  J. Eficacia de la rehabilitación respiratoria en pacientes con EPOC moderada en atención primaria y mantenimiento de los beneficios a los 2 años. Aten Primaria., 2006, 38(4):230-3

Dr Concepción Montón Soler

Pomares X., Montón C., Gallego M., Mariscal D., Acebo S., Castañer E., Vallés J., Marín A. Utilitat de la Proteïna C Reactiva en el diagnòstic i seguiment de l'exacerbació infecciosa de la malaltia pulmonar obstructiva crònica greu. XXV Diada Pneumològica de la SOCAP. Barcelona, Abril 2007. Annals de Medicina 2007; 90 (supl.3): 17

Pomares X., Montón C., Gallego M., Mariscal D., Vallés J., Castañar E., García A., Marín A. Utilidad de la Proteína C Reactiva en el diagnóstico y seguimiento de la exacerbación infecciosa de la EPOC severa. XL Congreso Nacional de la SEPAR. Barcelona, Junio 2007. Archivos de Bronconeumología 2007; 43: 62

Pomares X., Montón C., Gallego M., Mariscal D., Castañer E., Vallés J., Marín A. C-Reactive Protein usefulness in diagnosis and follow-up of COPD infectious exacerbations. European Respiratory Society 17th Annual Congress. Stockholm, September 2007. European Respiratory Journal 226s: E1380

Sancho M., Mariscal D., Castañer E., Montón C., Pomares X., Veigas C., Vallés J., Gallego M. Influència de les bronquiectàsies a les exacerbacions de la MPOC degudes a Pseudomonas Aeruginosa. XXVII Diada Pneumològica de la SOCAP. Barcelona, Març 2009. Annals de Medicina 2009 (in press)

Sancho M., Mariscal D., Castañer E., Montón C., Pomares X., Suárez D., Vallés J., Gallego M. Influencia de las bronquiectasias en las exacerbaciones de la EPOC debidas a Pseudomonas Aeruginosa. 42º Congreso Nacional de la SEPAR. Santander, Junio 2009. Archivos de Bronconeumología 2009 (in press)

Dr Josep Morera Prat

Efficacy of Moxifloxacin in the Treatment of Bronchial Colonization in Stable COPD Patients: a Randomised Placebo-Controlled Trial. European Respiratory Journal (re-submissió): (sent to publication)

Risk Factors for Bacterial Colonization in Patients with Stable. COPD (sent to publication)

Dr Mónica de la Peña Bravo

De la Peña M., Barceló A., Barbe F., Pierola J., Pons J., Rimbau E., Ayllón O., Agustí A. Endothelial function and circulating endothelial progenitor cells in patients with sleep apnea syndrome. Respiration. 2008;76(1):28-32

Barceló A., de la Peña M., Ayllón O., Vega-Agapito MV., Piérola J., Pérez G., González C., Alonso A., Agustí AG. Increased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apnea. Respiration. 2009;77(1):85-90

Dr Vicente Plaza Moral

Bellido J., Casado, Plaza V., Bardagí S., Cosano J., López Viña A., Martínez Moragón E., Rodríguez-Trigo G., Picado C., Sanchis J. ¿Disminuye la incidència de asma de Riesgo Vital en España?. Arch Bronconeumol 2006;42(10):522-5. PMID: 17067519

Bellido-Casado J., Plaza V., Belda J., Margarit G., Martínez-Brú C., Torrejón M., Sanchis J. Edema de la Mucosa Bronquial y Rapidez de Instauración de la Crisis de Asma. Med Clin (Barc) 2006;127(12):451-3. PMID: 17040630

Dr Laura Pujols i Tarrés

Dr Cristóbal Mezquita Pla

Pujols L., Fuentes M., Fernández-Bertolín L., Alobid I., Agell N., Roca-Ferrer J., Mullol J., Picado C. Little effect of glucocorticoids on fibroblast proliferation and collagen production by upper airway fibroblasts (in preperation)

Pujols L., Fuentes M., Fernández-Bertolín L., Alobid I., Agell N., Roca-Ferrer J., Mullol J., Picado C. Inhibition of airway fibroblast proliferation and function by the proteasome inhibitor MG262 (in preparation)

Pujols L. A new family of truncated intracellular isoforms of VEGFR-1, lacking the extracellular domains of the molecule, may contribute to the malignant phenotype of breast cancer cells. GenBank DQ836394, DQ836395, EF491868, EF491869 i EF491870

Pujols L. A new VEGFR-1 transcript coding for the extracellular domains of the protein followed by a C-terminal polyserine tail. GenBank: EU360600

Pujols L. Caracterització de les formes truncades intracel·lulars de VEGFR-1 (publication pending)

Dr  Jordi Rello Condomines

Rodriguez A., Torres A.,  Roig J.,  Sole-Violan J., Garnacho-Montero  J. ,  de la Torre M.Y., Sirvent J.M.,  Bodi M. for the CAPUCI study investigators, Rello J.  Implications of COPD in patients admitted to the intensive care unit by community- acquired pneumonia. Eur Respir J 2006; 7: 1210-1216

Koulentis D., Díaz E., Rodríguez A. et al. Severe respiratory infections in COPD patients. (preliminary results of the EU-VAP study) Intensive Care Med 2006; 32: S256 Abst 0989

Rello J., Rodriguez A. Severity of illness assessmente for managing community-acquired pneumonia. Intensive Care Med 2007; 33:2043-44

Lisboa T., Rello J. The simple and the simpler in pneumonia diagnosis. Crit Care 2007; 11:140

Veesenmeyer J., Hauser A., Lisboa T., Rello J. Pseudomonas aeruginosa virulence and therapy: Evolving trnslational strategies. Crit Care Med 2009 (in press)

Vallés J., Lisboa T., Rello J. Ventilator-associated pneumonia: the last 25 years In 25 years of progress and innovation. In Intensiva Care Medicine

Kuhlen R., Moreno R., Ranieri M., Rhodes A. (Eds) - Medizinisch 2007; pp 117

Lisboa T. , Rodríguez A., Rello J. Antibiotic combination vs monotherapy in critically ill patients with pneumonia. In Contreversies in Intensive Care Medicine

Kuhlen R., Moreno R., Ranieri M., Rhodes A. (Eds) - Medizinisch 2008; pp 175

Lisboa T., Rello J. Neumonía nosocomial por grampositivos. Enferm Infecc Microbiol Clin 2007; supl 4: 53

Rodriguez A., Lisboa T., Solé-Violán J., et al. Microbial upper airway colonization and ventilator-associated pneumonia in non-exacerbated COPD patients requiring invasive mechanical ventilation (submitted)

Dr Josep Roca Torrent

Ardite E., Barberà JÁ., Roca J,. Fernández-Checa JC. Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-?B activation. Am J Pathol 2004; 165 (3) 719-728

Casas A., Troosters T., Garcia-Aymerich J., Roca J., Hernandez C., Alonso A., Del Pozo F., de Toledo P., Anto JM., Rodriguez-Roisin R. Decramer M. Integrated care prevents hospitalizations for exacerbations in COPD patients. Eur Respir J. 2006 ; 28 :1-8

Rabinovich RA., Bastos R., Ardite E., Llinàs L., Orozco-Levi M., Gea J., Vilaró J., Barberà JA., Rodríguez-Roisin R., Fernández-Checa JC., Roca J. Mitochondrial dysfunction in COPD patients with low body mass index. Eur Respir J. 2007 Apr;29(4):643-50

Selivanov VA., Krause S., Roca J., Cascante M. Modeling of spatial metabolite distributions in the cardiac sarcomere. Biophys J. 2007 May 15;92(10):3492-500

Selivanov VA., Zeak JA., Roca J., Cascante M., Trucco M., Votyakova TV. The role of external and matrix ph in mitochondrial reactive oxygen species generation. J Biol Chem. 2008 Oct 24;283:29292-29300

Barreiro E., Rabinovich R., Marin-Corral J., Barberà JA., Gea J., Roca J. Chronic endurance exercise induces quadriceps nitrosative stress in patients with severe COPD. Thorax. 2009 Jan;64(1):13-9

Vilaro J., Rabinovich R., Gonzalez de Suso JM., Troosters T., Rodríguez D., Barberà JA., Roca J. Clinical assessment of peripheral muscle function in patients with chronic obstructive pulmonary disease. Am J Phys Med Rehabil. 2009 Jan;88(1):39-46

Hernandez C., Jansa M., Vidal M., Nuñez M., Bertran MJ., Garcia-Aymerich J., Roca J. The burden of chronic disorders on hospital admissions prompts the need for new modalities of care: a cross-sectional analysis in a tertiary hospital. QJM. 2009 Mar;102(3):193-202

Rodriguez DA., Garcia-Aymerich J., Roca J., Valera JL., Sauleda J., Togores B., Galdiz JB., Gea J., Orozco-Levi M., Ferrer A., Gomez FP., Agusti A., Barberà JA., Serra I., Antó JM. Body composition and systemic inflammation modulate exercise capacity in COPD patients. Am J Resp Crit Care Med (in revision)

Rodríguez DA., Alcarraz-Vizán G., Díaz-Moralli S., Reed M., Gómez FP., Günther U., Roca J., Cascante M. Plasma metabolic profile in copd patients - Effects of Lower Limb Exercise and Endurance Training (in revision)

Selivanov VA., Votyakova TV., Zeak JA., Trucco M., Roca J., Cascante M. Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation in hypoxia (in revision)

Muñoz PH., Villaquirán C., Gimeno E., Verdaguer-Codina J., Gómez FP., Rodriguez-Roisin R., Barberà JA., Roca J. Training-induced changes in skeletal muscle oxygenation (in revision)

Alonso A. et al. Enhanced integrated care management of COPD patients using a wireless point-of-care application JAMIA (in preparation)

Hernandez C. et al. Integrated care decreases disease mortality in severe COPO patients. Eur Respir J (in preparation)

Hernandez C. et al. The burden ot chronic disorders on hospital admissions prompts the need for new modalities of careo BMJ. (sent to evaluation) (Annex 1)

Hernandez C. et al. Factors limiting externa I validity ot disease-oriented integrated care programs in COPO patients. Archivos de Bronconeumologia (in preparation)

Barreiro E. et al. Training induced nitroso-redox unbalance in COPO patients with syst.emic effects. Thorax (in preparation) (Annex 2)

Muñoz Ph. et al. Assessment of skeletal muscle training effects by near-intrared spectroscopy. Eur Respir J (in preparation)(Annex 3)

Dr Robert Rodríguez Roisin

Dr Antonio Román Broto

Drakulovic MB., Gómez FP., Muñoz PA., Manrique HA., Burgos F., Valera JL., Roman A., Monforte V., Barberà JA., Roca J., Rodríguez-Roisin R. Gas exchange and pulmonary circulation in end-stage COPD undergoing lung transplantation. Proc Am Thorac Soc 2006; 3: A719

Drakulovic MB., Rodríguez DA., Gómez FP., Barberà JA., Roca J., Wagner PD., Rodríguez-Roisin R. ¿Cuál es el mejor post-BD FEV1 para practicar una gasometría arterial en pacientes con EPOC estable? Arch Bronconeumol 2008; 44: 48

Rodríguez DA., Drakulovic MB., Gómez FP., Barberà JA., Roca J., Wagner PD., Rodríguez-Roisin R. Fracción inpiratoria y desequilibrios ventilación-perfusión (VA/Q) en pacientes con EPOC estable. Arch Bronconeumol 2008; 44: 56

Almendros I., Gómez F., Rodríguez-Roisin R., Roman A., Navajas D., Farré R. Peripheral neutrophil stiffening in end-stage COPD patients undergoing lung transplantation. Eur Respir J 2008; 32 (Suppl 52)

Rodríguez-Roisin R., Drakulovic MB., Rodríguez D., Roca J., Barberà JA., Wagner PD. Ventilation-perfusion imbalance and chronic obstructive pulmonary disease severity. J Appl Physiol (in revision 09)

Dr Antoni Torres Martí

Dr Rosario Menendez Villanueva

Menéndez R., Martínez R., Reyes S., Mensa J., Filella X., Marcos MA., Martínez A., Esquinas C., Ramirez P., Torres A. Biomarkers improve mortality prediction by prognostic scales in community-acquired pneumonia. Thorax 2009 (in press)

Menéndez R., Martinez R., Reyes S., Mensa J., Polverino E., Filella X., Esquinas C., Martinez A., Ramirez P., Torres A. Biological markers and clinical stability in community-acquired pneumonia. do they add information? Clinical Infectious Diseases 2009 (in revision)

Gutierrez PT., Closa D., Piñer R., Bulbena O., Menéndez R., Torres A. Differential macrophage activation phenotype in COPD patients with community-acquired pneumonia. American Journal of Respiratory and Critical Care Medicine. 2009 (in revision)