MALALTIES INFLAMATÒRIES CRÒNIQUES. 2002.

Dr Doroteo Acero Fernández

Dr Jesús Garcia Gil

Dr Richard Day

Martinez-Medina M.; Aldeguer X., Gonzàlez-Huix F., Garcia-Gil LJ. 2006. Abnormal microbiota composition in the ileo-colonic mucosa of Crohn's disease patients as revealed by PCR-DGGE. Inflammatory Bowel Diseases 12: 1136-1145

Dr Juan Aguilar Piera

Egea,L.; Giménez R.; Badia,J.; Baldomà L.; Aguilar J. (2004). The pro- inflammatory agent PAF and the response to bacterial infection of Caco-2 epithelial cells. Proceedings of the workshop: Origin and evolution of human pathogens, Universidad Internacional de Andalucia y Instituto de Salud Carlos III

Egea,L.; Giménez,R.; Lúcia D.; Modolell I.; Badia J.; Baldomà L.; Aguilar J. (2008). Increased production of the ether-lipid platelet-activating factor in intestinal epithelial cells infected by Salmonella enteritidis. BBA-Molecular and cell biology of lipids (accepted manuscript doi: 10.10 16/j.bbalíp.2008.03.009 BBAMCB 56652)

Dr Fernando Albericio Palomera

Dr Enrique Pérez Payá

Mora P., Masip I., Cortés N., Marquina R., Merino R., Merino J., Carbonell T., Mingarro L., Messeguer A., Pérez-Payá E. Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins. J. Med. Chem. 2005, 48(4), 1265-1268.

Mora P., Mas-Moruno C., Tamborero S., Cruz LJ., Pérez-Payá E., Albericio F. Design of a Minimized Cyclic Tetrapeptide that Neutralizes Bacterial Endotoxins. J. Pept. Sci. 2006, 12, 491-496

Mas-Moruno C., Cruz LJ., Mora P., Messeguer A., Pérez-Payá E., Albericio F. The Smallest Peptoids with Anticancer Activity. J. Med. Chem. 2007, 50, 2443-2449

Mora P., López de la Paz M., Pérez Payá E. Bioactive Peptides Derived from the Limulus Anti-Lipopolysaccharide Factor: Structure-Activity Relationships and Formation of Mixed Peptide/Lipid Complexes. J. Pept. Sci. 2008, (in press)

Cascales L., Mas-Moruno C., Tamborero S., Sanz-Cervera JF., Fustero S., Cruz LJ., Mora P., Albericio F., Pérez-Payá E. Tiratricol neutralises bacterial endotoxins and reduces in cell lipopolysaccharide-induced TNF-alpha production. Bioorg. Med. Chem. Lett., (publication pending)

Mas-Moruno C., Cascales L., Cruz LJ., Mora P., Pérez-Payá E., Albericio F. Nanostructure formation enhances the activity of LPS-neutralizing peptides. J. Med. Chem., (publication pending)

Vicent MJ., Cascales L., Pérez-Payá E. Conjugation of novel anti-LPS molecules to poly-L-glutamic acid improves survival in an endoxemia murine model. (in preparation)

Dr Anna Bigas Salvans

Dr Guy Haegeman

Dr Dirk Elewaut

Aguilera C., Hoya-Arias R., Haeaeman G., Espinosa L., Bigas A. Recruitment of IkBalpha to the hes1 promoter is associated with transcriptional repression. Proc. Natl. Acad. Sci. USA, 101, 47, pp 16537-16542, 2004.

Aguilera C., Fernandez-Majada V., Inglés-Esteve J., Rodilla V., Bigas A., Espinosa Ll. Efficient Nuclear Export of p65-IkB complexes requires 14-3-3 proteins. J.Cell Sci. 119, 3695-3704, 2006.

Dewint P., Gossye V., De Bosscher K., .Vanden Berghe WW., Deforce D., Van Calenbergh S., Müller-Ladner U., Vander Cruyssen B., Verbruggen G., Haegeman G., .Elewaut D. A plant-derived ligand favouring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis. J. Immunol. 2008 Feb 15;180(4):2608-15.

Dr Ester Boix Borràs

Torrent M., Nogués MV., Boix E. A theoretical approach to spot active regions in antimicrobial proteins. (publication pending)

Boix E., Torrent M., Sánchez, D. and Nogués M.V. The Anti-Pathogen Activities Eosinophil Cationic Protein Current Pharm. Biotec. (2008), (in press)

Navarro S., Aleu J., Jiménez M., Boix E., Cuchillo CM., Nogués MV. The cytotoxicity of eosinophil cationic protein/ribonuclease 3 on eukaryotic cell lines takes place through its aggregation on the cell membrane. Cell. Mol. Life Sci., 65, 324-37 (2008).

Torrent M., Navarro S., Moussaoui M., Nogués MV., Boix,E. Eosinophil cationic protein high affinity binding to bacteria wall lipopolysaccharides and peptidoglycans. Biochemistry (2008), (in press)

Torrent M., Cuyás E., Carreras E., Navarro S., López O., de la Maza A., Nogués MV., Reshetnyak YK., Boix E. Topography studies on the membrane interaction mechanism of the eosinophil cationic protein. Biochemistry, 46, 720-33 (2007).

Boix E., Nogués MV. Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence. Mol Biosyst, 3, 317-35 (2007).

Carreras E., Boix E., Navarro S., Rosenberg HF., Cuchillo CM., Nogués MV. Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferation. Mol. Cell. Biochem., 272, 1-7 (2005).

Carreras E., .Boix E., Rosenberg HF., Cuchillo CM., Nogués MV. Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic protein. Biochemistry, 42, 6636-44 (2003).

Dr Maria del Carmen Caelles Franch

Ferré MS., Nicolàs M., .Morales M., Caelles C. KP-1 gene is a transcriptional target of the glucocorticoid receptor and modulates sensitivity to glucocorticoid treatment. (in preparation)

Dr Xavier Calvet Calvo

Motos J., Calvet X. Cobertura sociolaboral en enfermedades crónicas: invalidez permanente y minusvalía. Medicina Clínica 2007

Montserrat A., .Vergara M., Casellas F., Maudsley M., Gallardo O., Ricart E., Calvet X. Validation of the Spanish Work Productivity and Activity Impairment Questionnaire- Crohn's disease version. (SWPAI:CD). editorial review European Journal of Gastroenterology.

Vergara M., Montserrat A., Casellas F., Lario S., Mateo N., Dosal A., Calvet X. Validació del Work Productivity and Activity Impairment Questionnaire per la Malaltia de Crohn (MC).Resultats Preliminars. XVI Congrés de la Societat Catalana de Digestologia. Girona 1 al 3 febrer 2007. Suplements dels ANNALS de Medecina/Vol.90-Supl 1 Febrer 2007 pg.56.

Calvet X., Vergara M., Montserrat A., Casellas F., Lario S., Mateo N., Dosal A., Ricart E. Validación del Cuestionario "Work Productivity and Activity Impairment Questionnaire" para la Enfermedad de Crohn (EC). X Reunión de la Asociación Española de Gastroenterología. Madrid del 29 al 31 Marzo de 2007. Gastroenterología y Hepatología Marzo 2007;30(3) pag.146.

Vergara M., Casellas F., Montserrat A., Maudsley M., Gallardo O., Ricart E. et al. Validation of the work productivity and activity impairment questionnaire Crohn's disease version. (WPAI :CD). Presentat a Digestive Disease Week, Washington 2007. Gastroenterology 2007; 132(4):A172.

Dr Gabriel Gil Gómez

Roig, M.B.; Roset, R.; Anfosso, A.; Cabellos, L.; Garrido, M.; Brady, H.J.M.; Alameda, F. and Gil Gómez, G. (2008) Cyclin O function is required for DNA-damage and glucocorticoid induced apoptosis in lymphoid cells (in second revision Cell Death and Differentiation.)

Dr Cristina López Rodríguez

Dr José Francisco Aramburu Beltrán

Dr Juan Miguel Redondo Moya

Martínez-Martínez S., Rodríguez A., López-Maderuelo MD., Vázquez J., Redondo JM. Functional contribution ofthe NFATcl and NFATc2 mofits envolved in the interaction with calcineurin. Running rifle: Roles of NFATs-Calcineurin binding mofits. Mol. Cell. Biol, 2005 Manuscript M411878 (second revision).

Aramburu J., Drews-Elger K., Estrada-Gelonch A., Minguillón J., Morancho B., Santiago V., López-Rodríguez C. 2006. Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5. Biochem Pharmacol. 72:1597-1604.

Berga R., López-Rodríguez C. 2008. Lack of NFAT5 causes cell autonomous defects in the development and homeostasis of T lymphocytes.(manuscript in preparation)

Canellada A., Cano E., Sánchez- Ruiloba L., Zafra1 F., Redondo JM. 2006. Calcium-dependent expression of TNF-a in neural PC12 cells is mediated by the Calcineurin/NFAT pathway. Mol. Cell. Neurosci. 31:692-701.

Cano E., Canellada A., Minami T., Iglesias T., Redondo JM. 2005. Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway. J Biol Chem. 280:29435-2943.

Drews-Elger K., Rao A., López-Rodriguez C,. Aramburu J. 2008. Cell cycle defects and impaired expression of cyclins in NFAT5-deficient cells exposed to pathologic hypertonic conditions (submitted)

Martínez-Martínez S., Rodríguez A., López-Maderuelo MD., Vázquez J., Redondo JM. 2006. Blockade of NFAT activation by the second calcineurin-binding site. J.Biol Chem.281:6227-35.

Minguillón J., Buxadé M., Berga R., Aramburu J., López-Rodríguez C. 2008. Gene expression triggered by activated Toll-like receptors is regulated through the induction of NFAT5. (submitted)

Morancho B., Minguillón J., Molkentin JD., López-Rodríguez C., Aramburu J. 2008. Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Molecular Biology. 9:13.

Ortega-Pérez, Cano E., Were F., Vázquez J., Villar M., Redondo JM. 2005. Identification of phosphorylation sites involved in the regulation of NFATc2 transactivation by c-Jun NH2-terminal kinase (JNK). J. Biol Chem. 280:20867-20878.

Rodríguez A, et al., 2008. (manuscript in preparation)

Dr Consuelo Modesto Caballero

Modesto C., Rodriguez B., Arnal C. Results of an education program in pediatric r rheumatology adressed to primary care physicians (in preparation)

Modesto C., Antón J., Rodríguez B., Bou R., Ross J., Arnal C., Barceló P. Incidence and prevalence of juvenile idiopathic arthritis in Catalonia (Spain) (in preparation).

Dr Montserrat Núñez Juárez

Núñez M., Núñez E., del Val JL., Sanchez A., Bonet M., Roig D., Muñoz MD. y Arqualis Research Group. Calidad de vida relacionada con la salud en pacientes con artritis reumatoide. XXXII Congreso de la Sociedad Española de Reumatología (SER). Valencia, Maig 2006. Reumatol Clin 2006; 2: 46.

Núñez M., Núñez E., del Val JL., Sanchez A., Bonet M., Roig D., Muñoz MD. y Arqualis Research Group. Relación entre el tiempo de evolución de la enfermedad y el tratamiento en pacientes con artritis reumatoide. XXXII Congreso SER. Valencia, Maig 2006. Reumatol Clin 2006; 2:46-47.

Núñez M,. Núñez E., del Val JL., Sanchez A., Bonet M., Roig D., Muñoz MD. and Arqualis Research Group. Characterization of patients with rheumatoid arthritis according to the health care level. Annual European Congress of Rheumatology (EULAR) 2006. Amsterdam, Juny 2006. Ann Rheum Dis 2006; 65:597.

Núñez M., Núñez E., del Val JL., Sanchez A., Bonet M., Roig D., Muñoz MD. and Arqualis Research Group. Health-related quality of life questionnaire and perception of pain in patients with rheumatoid arthritis. Annual EULAR 2006. Amsterdam, June 2006. Ann Rheum Dis 2006; 65:597.

Núñez M., Núñez E., del Val JL., Sanchez A., Bonet M., Roig D., Muñoz MD. and Arqualis Research Group. Health-related quality of life in patients with rheumatoid arthritis. Annual EULAR 2006. Amsterdam, June 2006. Ann Rheum Dis 2006; 65:597.

Núñez M., Núñez E., del Val JL., Sanchez M., Roig D., Muñoz MD., Bonet M, and Arqualis Research Group. Patient perception of health-related quality of life in rheumatoid arthritis measured by qualitative and quantitative methods in Catalonia (Spain). Annual Scientif Meeting of American College of Rheumatology. Washington DC, Novembre 2006. Arthritis Rheum 2006;9: S117.

Núñez M., Núñez E., del Val JL., Fernandez-Huerta JM., Alegre C., Bonet M., Roig D., Gomez E., Godas T., Fernandez-Sola J. Health-related quality of life in chronic fatigue syndrome versus rheumatoid arthritis as control group. J Crhronic Fatigue Syndrome 2007; 14 :31-43.

Núñez M., Núñez E., Sanchez A., del Val JL., Bonet M., Roig D., Muñoz MD. and the Arqualis Research Group. Disease impact and patient´ s perception of health-related quality of life in rheumatoid arthritis: a quantitative-qualitative study. (submitted 2008).

Roig D., Núñez M., Núñez E., Sanchez A., del Val JL., Bonet M., Muñoz MD. and the Arqualis Research Group. Caracterización de pacientes con artritis reumatoide según el nivel asistencial. (submitted 2008)

Dr Mercè Pérez Riba

Dr Àngel Messeguer Peypoch

Aubareda A., Mulero M.C., i Pérez-Riba M. Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells. Cellular Signalling 18: 1430- 1438, 2006.

Márquez N., Sancho,R., Mach,A., Moure A., Masip I., Messeguer A. i Muñoz E. Anti-TAT and anti.HIV activity of trimers of N-alkylglycines. Biochem. Pharmacol., 71: 596-604, 2006.

Mulero MC., Aubareda A. i Pérez-Riba M. RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. BBA- Molecular Cell Research 1773: 330- 341, 2007.

Cortés,N., Messeguer A. Combinatorial Chemistry in Cancer Research. Clin. Transl. Oncol.: 9: 83-92, 2007.

Messeguer J., Cortés,N., Messeguer,A. et al., Design, synthesis and evaluation of a library of controlled mixtures of N-alkylglycines pentamers (in preparation)

Mulero MC., Aubareda A., Orzáez, M., Messeguer J., Messeguer A., Pérez-Payá E. i Pérez-Riba, M. A novel rcan peptide for immunosuppressant drug development that inhibits calcineurin-nfat signalling (in preparation)

Dr Josep Maria Piqué Badia

Dr Raúl Méndez de la Iglesia

Dr Angel Lanas Arbeloa

López J.M., Mendez R., Pique M. Cytoplasmic mRNA polyadenylation and translation assays. Methods in Molecular Biology. 322: 183-198

Piqué M., López JM., Foissac S., Guigó R. and Méndez R. A combinatorial code for CPE-mediated translational control. Cell, 132, 434-448 (2008).

Elíscovich C., Peset I., Vernos I., and Méndez R. Localized CPE-mediated translation controls meiotic chromosome segregation. (manuscript in second revision Nature Cell Biology.)

Peñalva M., Gisbert JP., Merino O., Luna ML. , Sans M., Piqué JM., Panés J. Nonsteroidal anti-inflammatory drug use and inflammatory bowel disease relapse: individual factors and disease-specific susceptibility factors. Presentat a Digestive disease week-2006. American Gastroenterology Association. Los Angeles ; USA, 2006. (manuscript in preparation)

Dr Adolfo Río Fernández

Dr Antonio Suárez Garcia

Dr German Soriano Pastor

Martínez, O., Montero T., Vieites J.M., Zarzuela A., Gassull M.A., Suárez M.O., LIor X., Sánchez de Medina F., Suárez A. Genomic analysis of the trinitrobenzenesulfonic acid model of colitis in the rat: a longitudinal study. Gut 2006 (submitted)

Martínez O., Montero T., LIor X., Vieites J.M., Gassull M.A., Suárez M.O., Zarzuela A., Sánchez de Medina F, Suárez A. Effect of sulfasalazine on the gene expression profile in rat trinitrobenzenesulfonic acjd colitis. Pharmacogenomics 2006 (in revision)

Montero T., Vieites J.M., Martínez O., Sánchez de Medina F., Gassull M.A., Llor X., Suárez A. Genomic analysis of the dextran sulfate model of rat colitis. Gut 2006 (in revision)

Montero T., Vieites JM., Sánchez de Medina F., Llor X., Martínez O., Gil A., Gassull MA., Suárez A. Genomic expression analysis reveals new molecular and cellular events involved in the pathogenesis of DSS-induced colitis. Pòster. Digestive Diseases Week, 2007. Washington D.C. (USA). Gastroenterology 2007; 132(4, suplS1): A395.

Montero T., Vieites JM., Llor X., Martínez O., Sánchez de Medina F., Gil A., Gassull MA., Suárez A. Comparative genomic analysis of rat IBD models identifies new genes and biological processes as potential therapeutic targets. Pòster. Digestive Diseases Week, 2007. Washington D.C. (USA). Gastroenterology 2007; 132(4, suplS1): A394.

Martínez O.,Montero T., Suárez A., Llor,X., Vieites JM., Suárez MD. Zarzuelo A., Gassull MA., Sánchez de Medina F. Effect of sulfasalazine on the colonic transcriptome in rat TNBS colitis. Pòster. Digestive Diseases Week, 2007. Washington D.C. (USA). Gastroenterology 2007; 132(4, suplS1): A234.

Montero T., Vieites JM., Llor X., Martínez O., Sánchez de Medina F., Suárez A. A comparative genomic perspective on murine inflammatory bowel disease models. Pòster. Digestive Disease Week 2006. Los Ángeles (USA). Gastroenterology 2006; 130(4, suppl.2):A551.

Montero T., Martínez O., Vieites JM., Llor X., Gassull MA., Suárez MD., Zarzuelo A., Suárez A., Sánchez de Medina F. Efectos de la sulfasalazina en el perfil de expresión génica de la colitis inducida pos ácido trinitrobencenosulfónico en ratas. Comunicació oral. Semana de las enfermedades digestivas, LXV Congreso anual de la Sociedad Española de Patología Digestiva. Granada. Revista Española de Enfermedades Digestivas 2006 ;98(supl.1):3.

Montero T., Vieites JM., Llo, X., Martínez O., Sánchez de Medina F., Suárez A. Análisis genómico comparativo de varios modelos animales de Enfermedad Inflamatoria Intestinal. Pòster. Semana de las enfermedades digestivas, LXV Congreso anual de la Sociedad Española de Patología Digestiva. Granada. Revista Española de Enfermedades Digestivas 2006; 98(supl.1): 39.

Dr Raimon Sanmarti Sala

Dr Isabel Haro Villar

Dr Marta Larrosa Padró

Dr Alejandro Balsa Criado

Pérez ML., Gómara M.J., Kasi D., Alonso A., Viñas O., Ercillaz G., Sanmartí R., Haro I. Synthesis of Overlapping Fibrin Citrullinated Peptides and their use for Diagnosing Rheumatoid Arthritis.  Chem Biol Drug Des 2006; 68: 194-200 (research article)

Pérez ML., Gómara J., Ercilla G., Sanmartí R., Haro I. Antibodies to citrullinated human fibrinogen synthetic peptides in diagnosing rheumatoid arthritis J. Med. Chem. 50, 3573-3584 (2007)

Vázquez I., Graell E., Gratacós J., Cañete JD., Viñas O., Ercilla MG., Gómez A., Hernández MV., Rodríguez-Cros JR., Larrosa M. and Sanmartí R. Prognostic markers of clinical remission in early rheumatoid arthritis after two years of Dmards in a clinical setting. Clin Exp Rheumatol 2007; 25: 232-8

Sanmartí R., Gómez-Centeno A., Ercilla G., Larrosa M., Viñas O., Vazquez I., Gómez-Puerta JA., Gratacós J. , Salvador G. and Cañete JD. Prognostic factors of radiographic progression in early rheumatoid arthritis. a two year prospective study after a structured therapeutic strategy using dmards and very low doses of glucocorticoids. Clinical Rheumatol 2007; 26: 1111-8.