1998. DIABETIS. PROJECTES FINANÇATS

Dr  Jordi Alberch Vié

Fariñas I, Jones KR, Tessarollo L, Vigers AJ, Huang E, Kirstein M, de Caprona DC, Coppola V, Backus C, Reichardt LF, Fritzsch B. (2001) Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci. 21 :6170-6180.

Fritzsch B, Beisel KW, Jones K, Fariñas I, Maklad A, Lee J, Reichardt LF. (2002) Development and evolution of inner ear sensory epithelia and their innervation. J Neurobiol. 53:143-156.

Fariñas I, Cano-Jaimez M, Bellmunt E, Soriano M. (2002). Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia. Brain Res Bull.57:809-16 Kirstein, M. and Fariñas, l. Sensing life: regulation of sensory neuron I survival by neurotrophins. Gell. Mol. Life Sci (2002) . (in press)

González-Martínez T., S. Gatania, B. Díaz-Esnal, M. Barbosa, D.F. Monjil, G. Germana, J.A. Vega, Human cutaneous meissner and pacinian corpuscles basic protein immunoreactivity: Fact or artefact? Neurosci. Lett.  (in press)

Vega, J.A., Kirstein, M., Valdés, T., Albuerne, M., Esteban, l., Giriaco, E., Silos- ¡ Santiago, l. and Fariñas, l. Lack of BDNF-signalling results in postnatal deficiencies in cutaneous mechanoreceptors in glabrous and hairy mouse skin.  (in preparation)

Valdés, T., Kirstein, M., Fariñas, l. Postnatal dependence of non-myelinated nociceptive sensory afferents on BDNF. (in preparation)

Dr  Jaume Arroyo Bros

Dr Begoña Campos Bonilla

Dr Anna Sanmartí Sala

Publicació en la revista Clinical Chemistry and Laboratory Medicine (suplement especial juny de 2003): "Association of adiponectin with insulin resistance and cardiovascular risk factors in Type 2 diabetes patients".

Referència bilbliogràfica: s252 Clin Chem Lab Med 2003; 41 Special Supplement, pp s1-S608, june 2003. En relació al Congrés International IFCC-FESCC Euromedlab'03 al juny del 2003 a Barcelona.

Publicació en la revista Diabetes and Metabolism (edició especial de l'agost de 2003): "Association of adiponectin with insulin resistance and cardiovascular risk factors in Type 2 diabetes patients".

Referència bibliografica: Diabetes Metab 2003,29,4S7-4S428. En relació amb el "18th International Diabetes Federation Congress" celebrat a París a l'agost de 2003.

Publicació en la revista Española de Obesidad, vol I, Nº 2- Novembre de 2003: "¿Qué riesgo cardiovascular presentan los pacientes con exceso de peso y diabetes mellitus tipo 2 incipiente?"

En relació amb el VI Congrés Nacional de la Sociedad Española de Obesidad (SEEDO) celebrat el novembre de 2003.

Publicació en la revista Atención Primaria de la Sociedad Española de Medicina Familiar y Comunitaria (SEMFYC), vol 32 Suplement I:93-125.

"La Adiponectina protege del riesgo cardiovascular de los pacientes con diabetes mellitus tipo 2?" En relació amb el XXIII Congrés Nacional Semfyc celebrat a Barcelona el desembre de 2003.

Dr  Susana Balcells Comas

Dr  M. Antònia Vilaseca Buscá

Dr  Xavier Pintó Sala

Balcells S, Urreizti R, Pintó X, Rodés M, Grinberg D,Vilaseca MA. Mutaciones del gen CBS en pacientes homocistinúricos. Llibre, IV Congreso Nacional de Errores Congénitos del Metabolism, 2001, p99

Balcells S, Urreizti R, Vilaseca MA, Grinberg D, Pinto X. The 844INS68 polymorphism in the CBS gene seems to be associated to a lower risk of coronary artery syndrom. European Journal of Clinical Investigation v 31 suppl 1: 28, 2001.

Balcells S, Urreizti R, Pinto X, Rodes M, Vilaseca MA, Grinberg D. CBS gene mutations in Spanish homocystinuric patients3rd. Llibre International Conference on Homocysteine Metabolism Sorrento, p 52

Dr  Ramon Bartrons Bach

M. Molas, R. Bartrons, J.C. Perales. Single-stranded DNA condensed with poly-L-lysine results in nanometric particles that are significantly smaller, more stable in physiological ionic strength fluids and afford higher efficiency of gene delivery than their doub le-stranded counterparts. Biochimica et Biophysica Acta 1572 (2002) 37-44

Dr  Joan M. V. Blasi Cabús

B. Torrejón, I. Gómez de Aranda and J. Blasi.  SNARE expression and distribution during 3T3-L1 adipocyte differentiation. FEBS Letters 512: 275-281 (2002)

F. Pérez-Brangulí, A. Muhaisen and J. Blasi. Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay. Molecular and Cellular Neuroscience 20: 169-180 (2002)

E.Martí, J. Blasi and I. Ferrer Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus.  Hippocampus 12 (2): 174-185 (2002)

 J. Aleu, J. Blasi, C. Solsona and J. Marsal Calcium-dependent acetylcholine release from Xenopus oocytes: Simultaneous currents and acetylcholine release recordings. European Journal of Neuroscience 16 (8): 1442-8 (2002)

M. A. Carmona, A. Martínez, A. Soler, J. Blasi, E. Soriano and F. Aguado. Ca2+-Evoked Synaptic Transmission and Neurotransmitter Receptor Levels are Impaired in the Forebrain of trkB (-l-) Mice. Molecular and Cellular Neuroscience 22(2): 210-226 (2003)

D. Reigada, I. Diez-Perez, P. Gorostiza, A. Verdaguer, I. Gómez de Aranda, O. Pineda, J. Vilarrasa, Marsal, J., J. Blasi, J. Aleu, C. Solsona. Control of Transmitter release by an internal gel-matrix in synaptic vesicles.  Proc. Natl. Acad. Sci (USA) 100(6): 3485-3490 (2003)

SNARE components in the insulin secretory cell line INS-1 (in preparation)

Characterization of cells stably transfected with pre-pro-insulin-GFP (in preparation)

Expression of SNARE proteins under different hyperglycemic conditions (in preparation)

Dr  Joan Bosch Cartes

M. Amat, N. LIor, M. Huguet, E. Molins, E. Espinosa, J. Bosch. Unprecedented Oxidation of a Phenylglycinol-Derived 2-Pyridone: enantioselective Synthesis of Polyhydroxypiperidines. Organic Letters 2001, 3, 3257-3260

Dr  Fàtima Bosch Tubert

M.George, E. Ayuso, A. Casellas, C. Costa, J.C. Devedjian and F Bosch. B-CELL EXPRESS ION OF INSULlN-LIKE GROWTH FACTOR-I LEADS TO RECOVERY FROM TYPE 1 DIABETES. J. Clin.Invest. (2002) 109(9),1153-1163 

P. Otaegui, M. Ontiveros, T. Ferre, E. Riu, R. Jimenez & F. Bosch. GLUCOSE-REGULATED GLUCOSE UPTAKE BY TRANSPLANTEE MUSCLE CELLS EXPRESSING GLUCOKINASE COUNTERACTS DIABETIC HYPERGL YCEMIA. Hum. Gene Ther. (2002) 13, 2125-2133

A. Mas, J.Montane, P. Otaegui, E. Riu, M.Chillon & F. Bosch. BASAL EXPRESS ION OF INSULIN IN SKELETAL MUSCLE TOGETHER WITH LOW DOSES OF SOLUBLE EXOGENOUS INSULIN MAINTAINS NORMOGLYCEMIA IN DIABETIC ANIMALS. (enviat)

A Mas, J.Montane, M.Chillon, E. Riu, P. Otaegui & F. Bosch. GLUCOKINASE EXPRESSION IN SKELETAL MUSCLE INCREASES INSULIN SENSITIVITY IN DIABETIC MICE. (sent)

E. Ayuso, M.Chillon, J. Agudo, V. Haurigot, A. Bosch, J. Ruberte, P. Otaegui & F. Bosch. IN VIVO GENE TRANSFER TO PANCREATIC B-CELLS BY SYSTEMIC DELlVERY OF ADENOVIRAL VECTORS. (in preparation)

Mas, J.Montane, M. Chillón, X. Martínez, S. Muñoz, M.Ontiveros, E. Riu, P. Otaegui & F. Bosch. INSULlN AND GLUCOKINASE GENE EXPRESSION IN SKELETAL MUSCLE REVERTS TYPE 1 DIABETES. (in preparation)

A. Casellas, A. Salavert, E. Ayuso, M. Moya, M. Garcia, J. Agudo & F. Bosch. INSULIN-LlKE GROWTH FACTOR-I EXPRESSION IN B-CELLS COUNTERACTS AUTOIMMUNE DIABETES. (in preparation)

George M., Ayuso E., Casellas A., Costa C., Devedjian JC., Bosch F. B-CELL EXPRESS ION OF INSULlN-LIKE GROWTH FACTOR-I LEADS TO RECOVERY FROM TYPE 1 DIABETES. J. Clin.Invest. (2002) 109(9), 1153-1163

Otaegui P., Ontiveros M., Ferre T., Riu E., Jimenez R., Bosch F. GLUCOSE-REGULATED GLUCOSE UPTAKE BY TRANSPLANTEE MUSCLE CELLS EXPRESSING GLUCOKINASE COUNTERACTS DIABETIC HYPERGL YCEMIA. Hum. Gene Ther. (2002) 13, 2125-2133

Dr  Jaume Campistol Plana

Mallolas J, Vilaseca MA, Pavia C, Cambra JF, Campistol J, Gomez D, Carrió A, Estivill X, Milá M. Large de novo deletion in chromosome 12 affecting the PAH,IGFI,ASCL1 and TRA1 genes. :J Mol Med 2000;15:987: A (I.F. 3.748). 

Mallolas J,Campistol J,Lambruschini N,Vilaseca MA,Estivill X,Milá M. Two novel Mutations in Exon 11 of the PHA Gene(V1163 del TG and P362T) associated with classic PKU and mild PKU. Hum Mut(ISSN 1059-7794) 2000 A(I.F. 2,642). 

Mallolas J,Vilaseca MA,Campistol J,Lambruschini N,Cambra FJ,Fusté E,Milá M. . Estudio clínico,bioquímico,neurológico y molecular d 11 pacientes que presentan mutaciones nuevas enel gen PAH. Rev Neurol 2000;31:907-910. CLAVE: A(I.F. 1'013)Código: Orden: 35

Campistol J,Gassió Vilaseca MA,Lambruschini N,Cambra FJ,Gomez L,Fusté E. Quality of life in PKU patients after diet introduction/reintroduction. J Inher Met Ois 2000;23 Suppl1 : 33

Dr  Enric Esmatjes Mompó

C. Mur, J. Clària, S. Rodela, S. Lario, J.M. Campistol, E. Titos , P. Iñigo, A. Cases, J. Abián, E. Esmatjes.

Cigarette smoke concentrate increases 8-epiPGF2aand TGFß 1 secretion in rat mesangial cells.

Life Science 2004 (in press).

Dr  Xavier Estivill Pallejà

N López-Bigas, R Rabionet, R de Cid, N Govea, P Gasparini, L Zelante, M Arbonés X Estivill. Splice-site mutation in the POS gene may result in intrafamilial variability for deafness in Pendred syndrome. Human Mutation 14: 520-526 (1999)

Y Bykhovshaya, X Estivill, K Taylor, T Hang, M Hamon, , N Fischel- Ghodsian. Candidate locus for a nuclear modifier gene for maternally inherited deafness. American Journal of Human Genetics 66: 1905- 1910 (2000)

R Rabionet, L Zelante, N López-Bigas, L D'Agruma, S Melchionda, G Restagno, M Arbones, P Gasparini, X Estivill. Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene. Human Genetics 106:40-44 (2000)

R Rabionet, P Gasparini, X Estivill. Molecular genetics of hearing impairment due to mutations in gap junction genes encoding beta connexins. Human Mutation 16: 190-202 (2000)

P Gasparini, R Rabionet, G Barbujani, ..., X Estivill and the Genetic Analysis Consortium of GJB2 35de1G. High carrier frequency of the 35delG deafness mutation in European pupulations. European Journal of Human Genetics 8:19-23 (2000)

X Estivill, R Rabionet. Molecular Basis of Deafness due to Mutations in the Connexin26 Gene (GJB2). In C. Peracchia (Ed), Current Topics in Membranes. Academic Press, San Diego, CA. 49:483-508 (2000)

N López-Bigas, R Rabionet, E Martínez, O Bravo, J Girons, A Borragán, M Pellicer, ML Arbonés, X Estivill. Mutations in the mitochondrial tRNA Ser(UCN) and in the GJB2 (conexin 26) gene are not modifiers of the age at onset and severity of hearing losss in Spanish patients with the 125 rRNA A1555G mutation. American Journal of Human Genetics 66: 1465-1466 (2000)

N López-Bigas, R Rabionet, M Arbones, X Estivill. R32W variant in Connexin 31: mutation or polymorphism for deafness and skin disease? European Journal ofHuman Genetics 9:70 (2001)

N López-Bigas, R Rabionet, X Estivill. Genética de la sordera. Identificación de las moléculas de la audición. Investigación y Ciencia, febrero 36-37 (2001)

N López-Bigas, S Melchionda, R de Cid, A Grifa, L lelante, N Govea, M Arbonés, P Gasparini, X Estivill. Identification of five new mutations of PDSjSLC26A4 in Mediterranean families with hearing impairment. Human Mutation 18 :548 (2001) Corrected and republished in: Hum Mutat. 2002 Jul;20(1):77-8.

N López-Bigas, N Govea, R Rabionet, ML Arbonés, X Estivill. Genética y genómica de la sordera no sindrómica. In E. Tomás y M Bernal (Eds). Tratado de Otorrinolaringología Pediátrica 227-235 (2001)

N López-Bigas, M Olivé, R Rabionet, O Ben-David, JA Martínez-Matos, O Bravo, I Banchs, V Volpini, P Gasparini, KB Avraham, I Ferrer, ML Arbonés, X Estivill. Connexin 31 (GJB3) is expressed in the peripheral and auditory nerves and causes neuropathy and hearing impairment. Human Molecular Genetics 10:947-952 (2001)

R Rabionet, N Lopez-Bigas, ML Arbones, X Estivill. Connexin mutations in hearing loss, dermatological and neurological disorders. Trends in Molecular Medicine 8:205-212 (2002)

N Lopez-Bigas, S Melchionda, P Gasparini, A Borragan, ML Arbones, X Estivill. A common frameshift mutation and other variants in GJB4 (connexin 30.3): Analysis of hearing impairment families. Human Mutation 19 :458 (2002)

N López-Bigas, ML Arbonés, X. Estivill, L Simonneau. Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea. Mechanisms of Development 2:111-115 (2002)

Dr  Jorge  Ferrer Marrades

Parrizas M, Maestro MA, Boj SF, Paniagua A, Casamitjana R, Gomis R, Rivera F, Ferrer J. Hepatic Nuclear Factor 1-alpha directs nucleosomal hyperacetylation of its tissue-specific transcriptional targets. Mol Cell Biol 2001:121(9)

Boj SF, Parrizas M, Maestro MA, Ferrer J. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc NatL Acad Sci USA. 14481-6.2001.

Frederiksen SK, *Párrizas M, Jensen M, Pruhova M, Ek J, Boj SF, Johansen, Maestro MA, Rivera F, Andel M, Jebl J, Pedersen 0, *Ferrer J, Hansen T. Genetic evidence that transcriptional control of HNF-4a by HNF1 a is essential for human pancreatic b-cell function. J Glin Invest. 2002 Sep;110(6):827-33 (*co-first author and co-corresponding author, respectively) 

Ferrer J. A Genetic Switch in Pancreatic beta-Cells: Implications for Differentiation and Haploinsufficiency. Diabetes. 2002 Aug;51 (8):2355-62.

Parrizas M, Boj SF, Luco RF, Maestro MA, Ferrer J. Chromatin immunoprecipitation using isolated islets of Langerhans. Methods Mol Med. 2003;83:61-71.

Mitchel SMS, Vaxillaire M, Thomas H, Parrizas M, Benmezroua V, Costa A, Hansen T, Owen KR, Tuomi T, Pirie F, Ryffel GU, Ferrer J, Froguel P, Hattersley A, Frayling T. Rare variants in the HNF4a b-cell specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type 2 diabetes. Diabetologia 2002.

Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O. Genetic variability of the SUR1 promoter in relation to beta-cell function and Type 11 diabetes mellitus. Diabetologia. 2001 Oct;44(10):1330-4.

Moritz W, Leech CA, Ferrer J, Habener JF. Regulated express ion of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Endocrinology. 2001 Jan;142(1):129-38.

Hernandez-Sanchez C, Ito Y, Ferrer J, Reitman M, LeRoith D. Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation. J Biol. Chem 274:18261-70, 1999.

Falany CN, Xie X, Wang J, Ferrer J, Falany JL. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. Biochem J. 2000 Mar 15;346 pt 3:857-64.

Ubeda M, Schmitt-Ney M, Ferrer J, Habener JF. CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun.1999 Aug 19;262(1):31-8.

Servitja JM, Ferrer J. Transcriptional networks controlling pancreatic development and beta cell function. 2004 Diabetologia Apr 1 [Epub ahead of print]

Maestro MA, Boj SF, Luco RF, Pierreux GE, Gabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J. Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell doma in of the embryonic pancreas. Hum Mol Genet 12(24): 3307-14, 2003

Dr  Cristina Fillat Fonts

C. Fillat, T. Español, M. Oset, M. Ferrando, X. Estivill, V. Volpini. Identification of WASP mutations in 14 Spanish families with Wiskott-Aldrich syndrome. Am. J. Med. Genetics (2001) 100:116-121.

J.L. Olivares, F.J. Ramos, T. Olivé, C. Fillat, M. Bueno. Autoinmune thyroiditis after bone marrow transplantation in a boy with Wiskott-Aldrich syndrome. J. Pediat.. Hemat. Oncol (2002) 24:772-776.

N. Andreu, N. Pujol-Moix, L- Martínez-Lostao, M. Oset, E. Muñiz-Díaz, X. Estivill, V. Volpini, C. Fillat. Wiskott-Aldrich syndrome in a female with skewed X-chromosome inactivation. Blood Cells Mol. Dis. (2003) 31:332-337.

N. Andreu, C. Carreras, F. Prieto, X. Estivill, V. Volpini, C. Fillat. Identification and characterization of a novel splice site mutation in a patient with Wiskott-Aldrich syndrome. J. Hum. Genet. (2003) 48:590-593.

N. Andreu, N. Matamoros, A. Escudero, G. Fontan, X. Estivill, V. Volpini, C. Fillat. Three novel mutations in Wiskott-Aldrich syndrome (in preparation).

N. Andreu, J.M. Aran, T. Español, X. Estivill, C. Fillat. Phenotypic correction of Wiskott-Aldrich syndrome defects in lymphoblastoid B and T cells after retroviral transduction. (in preparation).

Dr Jordi Garcia Fernàndez

Dr Gemma Marfany Nadal

Rosanas A., Marfany G.,  Garcia-Fernàndez J. All six ParaHox-cluster genes are expressed in subsets of pancreatic endocrine cells (submitted).

Rosanas A.,  Garcia-Fernàndez J.,  Marfany G. Transactivation of the insulin gene promoter by ParaHox transcription factors (in preparation).

Dr  Fausto García Hegardt

Miliar A, Serra D, Casaroli R, Vilaró S, Asins G, Hegardt FG. Developmental changes in Carnitine octanoyltransferase gene expression in intestine and liver of suckling rats Archives of Biochemistry and Biophysics (2001) 385, 283-289

Nicot C., Hegardt FG, Woldegiorgis G, Haro D,  Marrero P.F Pig liver carnitine palmitoyltransferase 1, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition is a natural chimera of rat liver and muscle enzymes Biochemistry (2001) 40, 2260-2266

Hegardt F.G, Bach M, Asins G, Caudevilla C, Morillas M, Codony C, Serra D. Post-transcriptional regulation of rat carnitine octanoyltransferase Biochemical Society Transactions (2001) 29 316-320

Morillas M, Gómez-Puertas P, Roca R., Serra D, Asins G, Valencia A., Hegardt, F.G. Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT) Journal of Biological Chemistry (2001) 276, 45001-45008

Rubí B., Antinozzi P,  Herrero L., Ishihara H, Asins, G, Serra D, Wollheim CW.,  Hegardt F.G. Adenovirus-mediated overexpression of liver carnitine palmitoyl transferase i in ins-1cells. effects on cell metabolism and insulin secretion Biochemical Journal (2002) 364, 219-226

Morillas M., Gómez-Puertas P, Rubí B, Clotet J, Ariño J, Valencia A., Hegardt FG, Serra D, Asins G. Structural model of a malonyl-CoA binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase lo Mutational analysis of a malonyl-CoA affinity domain Journal of Biological Chemistry (2002) 277, 11473-11480

Morillas M, Gómez-Puertas P, Bentebibel A, Sellés E, Casals N, Valencia A, Hegardt FG., Asins G, Serra D. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition Journal of Biological Chemistry (2003) 278, 9058-9063

Dr  Ramon Gomis de Barbarà

MC Muñoz, A. Barbera , J. Dominguez , J.Fernández-Alvarez, R.Gomis, JJ.Guinovart. Effects of tungstate, a new potential oral antidiabetic agent, in Zucker Diabetic Fatty (ZDF) rats. Diabetes 50: 131-138, 2001

Fernández-Alvarez J, Nada! B, Truc A, Claret M, Guinovart JJ, Gomis R. Tungstate induces normoglycemia in n-SIl rats by enhancing ¡3-cell neogenesis. Enviat per a publicació a la revista JCI .

M.Claret, H.Corominola, I.Canals, J.Saura, S.Barceló-Batllori, Joan J.Guinovart, R.Gomis, Tungstate Decreases Weight Gain and Adiposity in Obese Rats through Increased Thermogenesis and Lipid Oxidation. (2005) Endocrinology 146 (10): 4362-4369

Dr  Joan J. Guinovart Cirera

De la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ & Agius L. The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J. Biol. Chem. 275: 10597-10603 (2000)

Gomis RR, Cid E, García-Rocha M, Ferrer JC & Guinovart JJ. Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase. J. Biol. Chem. 277:23246-52. (2002)

Gomis RR, Favre C, García-Rocha M, Fernández-Novell JM, Ferrer JC, Guinovart JJ. Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase. J Biol Chem. 278:9740-6. (2003)

Ferrer JC, Favre C, Gomis RR, Fernández-Novell JM, García-Rocha M, de la Iglesia N, Cid E, Guinovart JJ. Control of glycogen deposition. FEBS Lett. 546:127-32. (2003)

Marin S, Lee WN P, Bassilian S, Lim S, Boros LG, Centellles JJ, Fernández-Novell JM, Guinovart JJ, Cascante M. Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]-glucose. Biochem. J. (en premsa 2004)

Yáñez AJ, García-Rocha M, Bertinat R, Concha II, Guinovart JJ, Slebe JC. Subcellular localization of liver FBPase is modulated by glucose, dihydroxyacetone and insulin.(in preparation).

Dr  Cristina Hernández Pascual

Piquer S, Hernández C, Enriquez J, Ross A, Esteban 1, Genesca J, Bonifacio E, Puig. Domingo M, Simó R. Islet Cell and thyroid antibody prevalence in patients with hepatitis C virus infection: effect of treatment with interferon. J Lab Clin Med 2001; 137: 38-42.

Hernandez C. High prevalence of glucose abnormalities in patients with hepatitis C virus infection. A large cohort study considering the liver damage. Rev. Diabetic Medicine. (in revision)

Dr  Albert J. Jovell Fernández

Jovell E, Jovell AJ. Calidad de la información en Internet. Siete Días Médicos num 600

Dr  Alberto de Leiva Hidalgo

Brugués E, Cermeño J, y Mercedes Rigla en representación de los Consorcios EuroDiabCare Q-Net y DiabCare España. Actividades en España de los Consorcios Europeos de Investigación DiabCare Q-Net y DiabCard (Resultados del período 1998- 2000). Av. Diabetol2000; 16 (Supl. 1): 58-A

Corcoy R, Cermeño J, Brugués E, Hernando E, Gómez E, de Leiva A y Consorcio T- 100M. Prueba piloto de la utilización del sistema T -100M en la práctica clínica. Av. Diabetol2000; 16 (Supl. 1): 58-A

J. Cermeño, R. Corcoy, E. Brugués, E. Hernando, E. Gómez, A. de Leiva. Utilidad Clínica del Sistema DIABtel en el seguimiento ambulatorio de pacientes tipo 1. Av. Diabetol2000; 16 (Supl. 1): 59-A

Cermeño J, Corcoy R, Brugués E, de Leiva A. Calidad de la información usada en el sistema Diabcare. Endocrinología 2000; 47 (Supl. 1): 32-A

Brugués E, Corcoy R, Cermeño J, Rigla M, Hernando E, Gómez E, de Leiva A. Telematic management of Type 1 diabetes: The T -100M Project. Diabetologia 2000; 43 (Suppl. 1): 906-A

Bellazzi R, Brugués E, Cobelli C, de Leiva A, del Prato S, Gómez E, Hernando E, Stefanelli M, Tuominen J. T -100M: Reports on the results of the EL! funded Project. Diabetes, Nutrition and Metabolism 2000; 13: 244-A

Bellazi R, Brugués E, de Leiva A, del Prato S, Gómez E, Hernando E, Roudsari A, Stefanelli M and the M2 DM Project Consortium. Multi-access services for DM management: The M2 DM Project. Diabetes, Nutrition and Metabolism 2000; 13. 249-A

Gómez E, Hernando E, Corcoy R, Cermeño J, Brugués E, de Leiva A, del Pozo F. Evaluation of the Diabtel Telemedicine System. Diabetes, Nutrition and Metabolism 2000; 13: 250-A

J. Cermeño, R. Corcoy, E. Brugués, E. Hernando, E. Gómez, A. de Leiva. Feasibility of Diabtel Use in the follow up of Type 1 Diabetic Patients. Diabetes Research and Clinical Practice 2000; 50: S210-A (P811)

Brugués E, Corcoy R, Cermeño J, Rigla M, de Leiva A. Telematic management of Type 1 DM: The T -100M Project. Diabetes Research and Clinical Practice 2000; 50: S57 -A (P 286)

Cermeño J, Corcoy R, Brugués E, de Leiva A. Quality of the Information used by the Diabcare System. Diabetes Research and Clinical Practice 2000; 50: S57-A (P 288).

Gómez, E. J, Hernando, M.E., Garcia, A, del Pozo, F., Corcoy, R., Brugués, E., Cermeño J., y de Leiva A, "Telemedicine as a tool for intensive management of diabetes: the DIABTel experience", Comp,. Meth. and Prog. in Biomedicine, 69(2002) 163-177.

E. Brugués, J. Cermeño, R. Corcoy, E. Hernando, E. Gómez-Aguilera, A. García, and A. de Leiva. Telemedicine may assist diabetic subjects to improve metabolic outcome and promote patient's empowerment. Diabetologia 2001; 44 (Suppl. 1): 224:A-59

JM. Cubero, M. Hernandez, E. Brugués, J. Cermeño, R. Corcoy and A. de Leiva. Metabolic outcome achieved by intensive management in european diabetes centers are far from derirable targets. Diabetologia 2001;44 (Suppl. 1):59:A17

G. Gallo, J. Cermeño, E. Brugués, M. Rigla, R.Corcoy and A. de Leiva. The burden of type 2 diabetes compared to the burden of type 1 diabetes in patients undergoing intensive and specialized careo Diabetologia 2001; 44 (Suppl. 1): 56:A-16

Dr  Pedro F. Marrero González

Barrero M, Marrero P, Haro D. Regulation of the Rat Liver Carnitine Palmitoyltransferase I gene transcription by Thyroid Hormone Biochem. Biophys. Res. Comm. 279, 81-88 (2000)

Nicot, C. Woldegiorgis, G., Hegardt, F.G., Haro, D. and Marrero P.F. Pig Liver Palmitoyltransferase I is a Natural Quimera with Low Carnitine Km and HighSensitivity to Malonyl-CoA. Biochemistry. 2001; 40: 2260-2266

Nicot, C., Relat, J., Woldegiorgis, G., Haro, D., and Marrero, P.F. Pig Liver Carnitine Palmitoyltransferase. Chimera Studies Show that Both the N- and C-Terminal Regions of the Enzyme are Important for the Unusual High Malonyl-Coa Sensitivity. J Biol Chem. 2002; 277:10044-10049.

MJ. Barrero, N. Camarero, P. F. Marrero and D. Haro. Control of human carnitine palmitoyltransferase I1 gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element. Biochem J.A (369, 721-729, 2003)

Á Baldán, P F. Marrero and D Haro. Peroxisome Proliferator -Activated Receptors a and y Differentially Regulate Muscle-specific Expression of Human Carnitine Palmitoyltransferase 1B (CPT1B) gene. 2003. (in preparation)

Nicot C., Hegardt FG., Woldegiorgis G., Haro D., Marrero PF. Pig Liver Carnitine Palmitoyltransferase 1, with Low Km For Carnitine And High Sensitivity to Malonyl-CoA Inhibition, is a Natural Chimera of Rat Liver and Muscle Enzymes Biochemistry, (in press) (2001)

Dr  Cristóbal Mezquita Pla

Mezquita J., Mezquita, P., Pau M., Mezquita, B., Francone, V., Vilagrasa, X. and Mezquita C. Genomic structure and alternative splicing of chicken Angiopoietin-2. Biochem Biophys Res Commun, 275: 643-651 (2000).

Mezquita J, Mezquita B, Pau, M and Mezquita, G. Down-regulation of Flt-1 gene expression by the proteasome inhibitor MG262. J. Gell. Biochem. 2003. (in press)

Dr  Eduard Montanya Mias

Biarnés M , Montolio M, Nacher V, Raurell M. Soler J, Montanya E. Hyperglycemia and beta cell death in syngeneically transplanted islets. Diabetes 2002;51:66-72

Montanya E. El trasplante de islotes de páncreas como terapia en la diabetes tipo 1. Endocrinologia 2001;48:223-225.

Berná G, León-Quinto T, Enseñat-Waser R, Montanya E, Martin F, Soria B. Stem Cells and Diabetes. Biomed Pharmacother 2001;55:206-12.

Biarnés M, Montolio M, Téllez N, Soler J, Montanya E.  Apoptosis and IL-1ßeta mRNA expression in syngeneic rat islet grafts.Diabetologia 2001;44(Suppl 1):A144.

Montolio M, Biarnés M, Téllez N, Soler J, Montanya E. Caspase inhibition reduces initial beta cell apoptosis in syngeneically transplanted islets. Diabetologia 2002;45(Supl 2):A138

Montolio M, Montanya E. Increased beta cell apoptosis in transplanted islets is reduced with caspase inhibitors. Avances en Diabetologia 2002;18:189.

Montolio M, , Téllez N, Biarnés M, Soler J, Montanya E. Short term islet culture with the caspase inhibitor z-VAD.fmk reduces beta cell apoptosis after transplantation and improves the metabolic outcome of the graft. (sent)

Biarnés M, Montolio M, Téllez N, Escoriza J, Soler J, Montanya E. Increased expression of IL-1ß and iNOS in early syngeneic islet trasplantation. (sent).

Dr  Anna Novials Sardà

Dr  Elena Fernández Usac

Dr  Anne Clark

Novials. A , Rojas. I, Franco. C, Casamitjana. R, Fernández Usac. E, Gomis. R. A novel mutation in eslet amyloid polypeptide (IAPP) gene romotor is associated with Type II diabetes mellitus. Diabetologia , 44 - 2001 (1064-1065)

Dr  Rafael Oliva Virgili

Sánchez M., Bruguera M., Quintero E., Barrio Y., Mazzara R., Rodés J. and Oliva R. (2000) Hereditary Hemochromatosis in Spain. Genetic Testing, 4, 171-176.

Sánchez M,, Bruguera M,, Rodés J, and Oliva R, (2001) Complete characterization of the 3' region of the hurnan and mouse hereditary hemochromatosis HFE gene and detection of novel splicing forros. Blood Cells, Molecules, and Diseases, 27, 35-43

Sanchez M., Villa M., Ingelmo M., Sanz C., Bruguera M., Ascaso C., Oliva R. (2003) Population screening for hemochromatosis: a study in 5370 Spanish blood donors. Journal of Hepatology 38, 745-750.

Oliva R., Novials A., Sanchez M., Villa M., Ingelmo M., Recasens M., Ascaso C., Bruguera M., Gomis R. The HFE Gene 1s Associated to an Earlier Age of Onset and to the Presence of Diabetic Nephropathy in Diabetes Mellitus Type 2. Endocrine. 2004 Jul; 24(2) :111-4

Dr  Jordi Ordóñez Llanos

JL Sánchez-Quesada, A Pérez, A Caixàs, M Rigla, A Payés, S Benítez, J Ordóñez-Llanos. Effect of glycemic optimization on electronegative low density lipoprotein in diabetes: relation to nonenzymatic glycosylation and oxidative modification. Journal of Clinical Endocrinology and Metabolism 2001 ;86:3243-3249.

Dr  Rosanna Paciucci Barzanti

Paciucci R, Tor' M, Dmaz VM, Real FX. The plasminogen activator system in pancreas cancer: role of t-PA in the invasive potential in vitro. Oncogene 1998;16(5) :625-633.

Batlle E, Verdz J, Dommnguez D, Llosas MM, Dmaz VM, paciucci R, Alameda F, Garcia de Herreros A. Protein kinase C-alpha activity inversely regulates invasion of growth of intestinal cells. J Biol Chem 1998;273:15091-15098.

Paciucci R, Vila MR, Adell T, Dmaz VM, Tor' M, Nakamura T, Real FX. Activation of u-PA/u-PAR system and redistribution of E-cadherin are associated with HGF-induced motility of pancreas tumor cells overexpressig Met. Am J Pathol 1998;153:201-212.

Paciucci, R, Benedit, P., Thomson, T,. Valeri, M., Nadal,M., C'ceres, C., de Torres, l., Estivill, X., Lozano, J.J., Morote, J. and Reventss,J. PTOV1, a novel protein overexpressed in prostate cancer, contains a new class of protein modules. Oncogene 2001; 20: 1455-1464.

Diaz V M, Planagum' J, Thomson T, Reventss J and Paciucci R. Tissue plasminogen activator is required for the growth, invasion and angiogenesis of pancreatic tumor Cells. Gastroenterology 2002; 122:806-819.

Santamarma A, Fernandez P, Farri X, Benedit P, Reventss J, Morote J, Thomson TM and Paciucci R. PTOV-l, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. The American Journal of Pathology (octubre de 2002, in press)

Dr. Joan Prat Corominas

Ruiz MC, Portero-Otin M, Pamplona R, Requena JR, Pral J, Lafarga MA, Borras M, Bellmunt MJ. Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids. Perit Diallnt. 200323(1): 23-32.

Portero-Otin M, Pamplona R, Bellmunt MJ, Ruiz MC, Prat J, Salvayre R, Negre-Salvayre A. Advanced glycation end product precursors impair epidermal growth factor receptor signaling. Diabetes. 2002 51 (5): 535-42.

J Prat. Aging Increases Nl\epsilon -(Carboxymethyl)lysine and caloric restriction decreases Nl\epsilon -(malondialdeyde)lysine in rat heart mitochondrial proteins. Free Radical Research, 2002, 36(1),47-54

Dr  Francisco X. Real Arribas

Soria B, Skoudy A , Martin F. From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 2001; 44:407-415.

Skoudy A, Rovira M, Savatier P, Martín F, Leon-Quinto T, Soria B, Real FX. Transforming growth factor beta, fibroblast growth factor, and retinoid signalling pathways promote exocrine gene expression in mouse embryonic stem cells. Biochem J 2004; 379:749-756.

Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, Moreno B, Lloreta J, Field SJ, Real FX, Zubiaga A. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 compound mutant mice reveals essential roles for these genes in pancreatic growth and differentiation. J Clin Invest 2004 (in press).

Esni F, Ghosh B, Biankin AV, Lin JW, Yu X, MacDonald RJ, Civin CI, Real FX, Ball DW, Leach SD. Notch inhibits exocrine differentiation in developing mouse and zebrafish pancreas. Development 2004 (in press).

León-Quinto, Jones J, Skoudy A, Burcin M, Soria B. Directed differentiation of mouse embryonic stem cells towards insulin-producing cells. Diabetologia 2004  (in press).

Rodolosse A, Chalaux E, Skoudy A, Adell A, Hagège H, Real FX. The pancreas-specific transcription factor p48 couples cell differentiation to cell proliferation. Gastroenterology (second revision).

Pujal J, Capellà G, Real FX. The Wnt pathway is active in a subset of pancreatic cancers. (submitted).

Dr. Manuel Reina del Pozo

Berndt C, Casaroli-Marano RP, Vilaro S, Reina M. Cloning and characterization of human syndecan-3. J Cell Biochem 2001;82(2):246-59

Dr  Cristóbal Richart Jurado

Fernández-Real JM, Láinez B, Vendrell J, Rigla M, Castro A, Peñarroja G, Broch M, Pérez A, Richart C, Engel P, Ricart W. Shedding of TNF-alfpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 2002; 282:E952-959

Vozarova B, Fernández-Real JM, Knowler WC, Gallart L, Hanson RL, Gruber JD, Ricart W, Vendrell J, Richart C, Tataranni PA, Wolford JK. The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet 2003;112:409-13

Vendrell J, Fernández-Real JM, Gutiérrez C, Zamora A, Simón I, Bardají A, Ricart W, Richart C. A polymorphism in the promoter of the tumor necrosis factor-alfpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients. Atherosclerosis 2003; 167:257-264

Vendrell J, Broch M, Fernández-Real JM, Gutiérrez C, Simón I, Megia A, Gallart L, Ricart W, Richart C.

Tumor necrosis factor receptors (TNFRs) in type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study. Diabetic Medicine 2004 (in press).

Dr  Emili Ros Rahola

Ros E, Rodríguez-Villar C, Núñez 1, Gilabert R, Conget I. Endothelial dysfunction in healthy subjects without cardiovascular risk factors but with variable adiposity is related to visceral fat accumulation. 35th Annual Meeting of the European Society for Clinical lnvestigation, Barcelona, 2-5 Maig 2001 (Eur J Clin Invest 2001 ;31 [Suplo 1]:26).

Rodríguez-Villar C, Casals E, Núñez I, Gilabert R, Conget I, Ros E. Disfunción endotelial en pacientes con mínimas alteraciones del metabolismo lipídico e hidocarbonado. XIV Congreso Nacional de la Sociedad Española de Arteriosclerosis, Barcelona, 2-5 Maig 2001 (Clin Invest Arterioscler 2001;13 [Suplo 2]:41-42).

Rodríguez-Villar C, Conget I, Nuñez I, Gilabert R, Mercadé 1, Casal s E, Ros E. Perfiles diurnos de trigliceridemia y glucemia capilar como marcadores de riesgo cardiovascular. XXVII Congreso Nacional de Diabetes, Cádiz, 2-4 Març; 2002. (Avances en Diabetología 2002, vol 18, supl.1 :36)

Rodríguez-Villar C, Conget I, Núñez I, Gilabert R, Mercadé I, Casal s E, Ros E. Perfiles diurnos de trigliceridemia y glucemia capilar en controles sanos, sujetos con hipertrigliceridemia leve y diabéticos. Relación con aterosclerosis preclínica. XV Congreso Nacional de la Sociedad Española de Atherosclerosis, Salamanca, 1-4 Maig 2002. (Clin Invest Arterioscler 2002;14 [Suplo 2]:20).

Dr  Bernat Soria Escoms

Soria B, Skoudy A, Martin F (2001) From stem cells to J3-cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 44: 407 - 415

Berna G, León-Quinto T, Enseñat-Wasser R, Montanya E, Martín F, Soria B (2001) Stem cells and Diabetes. Biomed Pharmacother. 55 : 206- 212

Soria B (2001) In-vitro differentiation ofpancreatic J3-cells Differentiation 68: 205-219

Soria B (2001) Trasplante de islotes pancreáticos y de celulas diferenciadas a partir de células madre. Avances en Diabetología 17: 121-128

Berna G, León-Quinto T, Fuentes E, Andreu E, Nadal A, Roche E, Martin F, Reig JA, Soria B. Ingeniería Celular y Diabetes Mellitus. Rev Clin Esp 201: 548-556

Quesada I, Rovira JM, artín F, Roche E, Nadal A, Soria B (2002) Nuclear KA TP channels trigger nuclear Ca2+ transients and gene expression. Proc Natl Acad Sc USA 99(14): 9544- 9549

Reig JA, Enseñat-Waser R, Roche E, Soria B (2002) "Terapia Celular en_la Diabetes Mellitus" Endocrinol Nutr 49(8): 260-268

Maestre 1, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E. (2003) Mitochondrial Dysfunction Is Involved in Apoptosis Induced by Serum Withdrawal andPattyAcids in fue beta-Cell Line Ins-1. Endocrinology 144(1): 335-345.

Dr  Francesc Villarroya Gombau

Pedraza, N.; Solanes, G.; Carmona, M.C.; Iglesias, R.; Viñas, O.; Mampel, T.; Vazquez, M.; Giralt, M.; Villarroya, F. Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactaton. Fibrates and troglitazone reverse lactation-induced down-regulation of the uncoupling protein-3 gene. Diabetes 49, 1224- 1230, 2000

Solanes G., Pedraza N., Iglesias R., Giralt M., Villarroya, F. The human uncoupling protein-3 gene promoter requires MyoD and is induced by retinoic acid in muscle cells. Faseb Journal 10.1986, fj.00-0363 (edició on-line), 14,2141-2143 (edició en paper),: 2000.

Pedraza, N.; Solanes, G.; Iglesias, R.; Vazquez, M.; Giralt, M., Villarroya, F. Differential regulation of uncoupling protein-2 and -3 gene expression in brown adipose tissue during lactation in mire. Biochemical Joumal, 355 105-111, 2001 

F Villarroya Gombau Pedraza, N.; Solanes, G.; Carmona, M.C.; Iglesias, R.; Viñas, O.; Mampel, T.; Vazquez, M.; Giralt, M.; Villarroya, F. Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactato n. Fibrates and troglitazone reverse lactation-induced down-reg ulation of the uncoupling protein-3 gene. Diabetes 49, 12 24- 1230, 2000

F Villarroya Gombau Solanes G., Pedraza N., Iglesias R., Giralt M., Villarroya, F. The human uncou pling protein-3 gene promoter requires MyoD and is induced by retinoic acid in muscle cells Faseb Journal 10.1986, fj.00-03 63 (edició on-line), 14,2141-2143 (edició en paper),: 2000.

Dr  Marta Vives Pi

Alba A., Puertas MC., Carrillo J., Planas R., Ampudia R., Pastor X., Bosch F., Pujol-Borrell F., Verdaguer J., Vives-Pi M. The transgenic expression ofIFN beta in islet beta cells breaks the tolerance in non-diabetes prone strains and accelerates autoirnmune type 1 diabetes in NOD mice. (in press) J. Imnmunology

Dr  Antonio Zorzano Olarte

N. Morin, J.M. Lizcano, E. Fontana, L. Martí, F. Smih, P. Rouet, D. Prevot, A. Zorzano, M. Unzeta, C. Carpéné. Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipólisis in human adipocytes. Journal of Pharmacology and Experimental Therapeutics 297, 563-572, 2001.

L. Martí, A. Abella, C. Carpéné, M. Palacín, X. Testar, A. Zorzano. Combined treatment with benzylamine and low doses of vanadate enhances glucose tolerance and reduces hyperglycemia in streptozotocin-induced diabetic rats. Diabetes 50, 2061-2068, 2001.

Consenso del grupo de trabajo "Resistencia a la Insulina" de la Sociedad Española de Diabetes. La resistencia a la insulina y su implicación en múltiples factores de riesgo asociados a diabetes tipo 2 Medicina Clínica 119, 458-463, 2002.

A. Zorzano, A. Abella, L. Martí, C. Carpéné, M. Palacín, X. Testar. Semicarbazide-sensitive amine oxidase activity exerts insulin-like effects on glucose metabolism and insulin-signaling pathways in adipose cells. Biochim. Biophys. Acta 1647, 3-9, 2003.

A. Abella, L. Martí, M. Camps, M. Claret, J. Fernández-Alvarez, R. Gomis, A. Gumà, N. Viguerie, C. Carpéné, M. Palacín, X. Testar, A. Zorzano.  SSAO/VAP-1 activity exerts an anti-diabetic action in Goto-Kakizaki rats. Diabetes 52, 1004-1013, 2003.

D. Bach, S. Pich, F.X. Soriano, N. Vega, B. Baumgartner, J. Oriola, J.R. Daugaard, J. Lloberas, M. Camps, J.R. Zierath, R. Rabasa-Lhoret, H. Wallberg-Henriksson, M. Laville, M. Palacín, H. Vidal, F. Rivera, M. Brand, A. Zorzano. Mitofusin-2 determines mitochondrial architecture and mitochondrial metabolism: a novel regulatory mechanism altered in obesity. J. Biol. Chem. 278, 17190-17197, 2003.

Zorzano A. Terapia génica en endocrinología: una aproximación realista . Endocrinología 50, 244 - 249, 2003.

A. Abella, L. Martí, C. Carpéné, M. Palacín, X. Testar, Zorzano A. Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats. J. Physiol. Biochem. 59, 225-232, 2003.

Stolen CM, Madanat R, Marti L, Kari S, Yegutkin GG, Sariola H, Zorzano A, Jalkanen S. Semicarbazide-sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications. FASEB J. 18, 702-704, 2004.

Abella A, García-Vicente S, Viguerie N, Ros-Baro A, Camps M, Palacin M, Zorzano A, Martí L. Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regulated manner. Diabetologia 47, 429-38, 2004.

Visentin V, Prevot D, De Saint Front VD, Morin-Cussac N, Thalamas C, Galitzky J, Valet P, Zorzano A, Carpene C. Alteration of Amine Oxidase Activity in the Adipose Tissue of Obese Subjects. Obes. Res. 12, 547-555, 2004.