1996. MALALTIES NEUROLÒGIQUES. PROJECTES FINANÇATS

Dr  Josep M. Argimon Pallàs

Vinyoles E, Copetti S, Cabezas C, Megido MJ, Espinàs J, Vila J, Montella N, Martínez A, Argimon JM y Grupo de Estudio CUIDA´L.  Aspectos metodológicos de un ensayo clínico que evaluará la eficacia de una intervención en cuidadores de pacientes demenciados. Aten Primaria 2001;27:49-53.

Vinyoles E, Vila J, Argimon JM, Espinàs J, Abos T, Limón E, en representación de los investigadores del grupo Cuida´l. Concordancia entre Mini Examen Cognoscitivo y el Mini Mental State Examination en el cribado de dèficit cognitivo. Aten Primaria 2002; 30: 5-15.

Dr  Aurelio Ariza Fernández

Ariza A. Enfermedades causadas por virus.Neuropathologia. FF Cruz-Sánchez (ed). Editores Médicos SA, Barcelona, 2000; p.347-360.

Ariza A, Mate JL, Navas-Palacios JJ. Overexpression of cyclins A and B1 in JC virus-infected cells of progressive multifocal leukoencephalopathy.Modern Pathology 1998; 11(1):158A.

Muñoz-Mármol AM, Strasser G, Isamat M, Coulombe PA, Yang Y, Roca X, Vela E, Mate JL, Coll J, Fernández-Figueras MT, Navas-Palacios JJ, Ariza A. Fuchs E. A dysfunctional desmin mutation in a patient with severe generalized myopathy.Proceedings of the National Academy of Sciences USA 1998; 184:83-88.

Ariza A, Mate JL, Isamat M, Calatrava A, Fernández-Vasalo A, Navas-Palacios JJ. Overexpression of Ki-67 and cyclins A and B1 in JC virus-infected cells of progressive multifocal leukoencephalopathy.Journal o Neuropathology and Experimental Neurology 1998; 57(3):226-230.

Muñoz-Mármol AM, Strasser G, Isamat M, Coulombe P, Yang Y, Roca X, Vela E, Mate JL, Coll J, Fernández-Figueras MT, Navas-Palacios JJ, Ariza A, Fuchs E. A dysfunctional desmin mutation in a patient with severe generalized myopathy. Proceedings of the National Academy of Sciences USA 1998; 95: 11312-11317.

Dr  Joaquim V. Arribas López

Merlos-Suarez A, Arribas J. Mechanisms controlling the shedding of transmembrane molecules.Biochemical Society Transactions 27:2, 243-246. 1998

Merlos-Suarez A, Fernández-Larrea J, Reddy P, Baselga J, Arribas J. Pro-Tumor Necrosis Factor-a Processing Activity Is TightlyControlled by a Component That Does Not Affect notch Processing.Journal of Biological Chemistry 273, 24955-24962. 1998

Fernández-Larrea J, Merlos-Suarez A, Ureqa JM, Baselga J, Arribas J. A. Arole of a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.Molecular Cell 3, 423-433.1999

Merlos-Suárez, A, Ruiz-Paz, Baselga, J. & Arribas, J Metalloprotease-dependent proTGF-a ectodomain shedding in the absence of TACE 2001 J Biol Chem 276, 48510-48517

Borrell-Pagès, M., Fernández-Larrea, J., Borroto-Revuelta, A., Rojo, F., Baselga, J. & Arribas, J.The carboxy-terminal cysteina of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein.2000 Mol Biol Cell 11, 4217-4225

Arribas, J., Blackburn, R. K., Weskamp, G., Tempst, P. & Blobel, C.. Roghani, M., Becherer, J. D., Moss, M. L., Atherton, R. E., Erdjument-Bromage, H Metalloprotease-Disintegrin MDC9: Intracellular maturation and catalytic activity . 1999 J Biol Chem 274, 3531-3540.

Dr  Pelayo Camps García

Dr  Albert Badia Sancho

Dr  Francisco Javier Luque Garriga

P. Camps, R. El Achab, D. M. Gorbig, J. Morral, D. Muñoz-Torrero, A. Badia, J. E Baños, N. M. Vivas, X. Barril, M. Orozco, F. J. Luque, Synthesis, in Vitro Pharmacology, and Molecu1ar Modeling of Very Potent Tacrine-Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for fue Treatment of Alzheimer's Disease, Journal of Medicinal Chemistry, 1999,42, 3227-3242 

P. Camps, J. Contreras, J. Morral, D. Muñoz-Torrero, M. Font-Bardia, X. Solans, Synthesis of an 11-Unsubstituted Analogue of (+-)- Huperzine A, Tetrahedron, 1999,55, 8481-8496 

X. Barril, M. Orozco, F. J. Luque, Predicting Relative Binding Free Energies of Tacrine-Huperzine A Hybrids as Inhibitors of Acetylcholinesterase, Journal 01 Medicinal Chemistry, 1999,42, 5110-5119-

P. Camps, B. Cusack, W. D. Mallender, R. El Achab, J. Morral, D. Muñoz-Torrero, T. L. Rosenberry, Huprine X is a Novel High Affinity Inhibitor of Acetylcholinesterase That Is of Interest for the Treatment of Alzheimer's Disease, Molecular Phannacology, 2000, 57, 409-417 

P. Camps, J. Contreras, J. Morral, D. Muñoz-Torrero, M. Font-Bardia, X. Solans, A New Synthesis of (:t)-Huperzine A and its 7-Ethyl Analogue. Acetylcholinesterase Inhibitory Activity of Several Huperzine A Analogues, Tetrahedron, 2000,56,4541-4553.

P. Camps, R. El Achab, J. Morral, D. Muñoz-Torrero, A. Badia, J. E. Baños, N. M. Vivas, X. Barril, M. Orozco, F. J. Luque, Highly Potent 1- and / or 3-Substituted Tacrine-Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease, Journal of Medicinal Chemistry, 2000,43, 4657- 4666.

P. Camps, D. Muñoz-Torrero, Tacrine-Huperzine A Hybrids (Huprines): A New Class of Highly Potent and Selective Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease, Mini Reviews in Medicinal Chemistry, 2001, en premsa.

P. Camps, D. Muñoz-Torrero, M. Simon, Easy Access to 4-Substituted (+-) Huperzine A Analogues, Synthetic Comm.unications, 2001, en premsa. 

H. Dvlr, M. Harel, X. Baml, M. Orozco, F. J. Luque, D. Munoz-Torrero, P. Camps, T. L. Rosenberry, l. Silman, J. L. Sussman, 3D Structure of acetylcholinesterase complexed with the novel high-affinity inhibitor huprine X, at 2.1 A resolution, en curs de redacció.

Pelayo Camps, Elena Gómez, Diego Muñoz- Torrero, Manuel Amó. On the regiose1ectivity afilie Friedlander ctionleading to huprines: stereospecific acid-promoted isomerization of syn-h es to their anti-regioisomers. cc' Tetrahedron Asymmetry, 2001, 1 "'09-2914.

Esteve Ros, Jordi Aleu, Inmaculada mez de Aranda, Diego Muñoz- Torrero, Pelayo camps, Albert badia, Jordi Mar, Carles Solsona. The pharmacology of novel aceth linesterase inhibitors, (:t)-huprines Y and X, on fue Torpedo electric organ European Journal of Pharmacology, 2001, 421,77-84. 

R. Dvir, D. M. Wong, M. Rarel, X. Barril, M. Orozco, F.J. Luque, D. Muñoz- Torrero, P. Camps, T .L. Rosenberry, 1. Silman, J. L. Sussman 3D structure ofTorpedo califomica acetylcholinesterase complexed with huprine X at 2.1 A reso1ution: kinetic and molecular dynamic correlates. Biochemistry, 2002, en premsa

P. Camps, D. Muñoz-Torrero, Cholinergic Drugs in Pharmacotherapy of Alzbeimer's Disease, Mini Reviews in Medicinal Chemistry, 2002,2, 11-25

X. Barril, M. Orozco, F. J. Luque, Predicting Relative Binding Free Energi Tacrine-Huperzine A Hybrids as Inhibitors of Acetylcholinesterase, Journal of Medicinal Che 10-5119.

N.M. Vivas, M.M. Alcalá, S. Hospital, J.E. Baños, A. Badia. Effects of two Ta-crine- c Huperzine A hybrids on acetylcholinesterase (AChE) and butirylcholinesterase (BChE) activities. Methods and Fíndings ín Experimental and Clínical Pharmacology, 2000, 22(6), 437.

X. Barril, J. L. Gelpí, J. M. López, M. Orozco, F. J. Luque. How Accurate Can MD/LR and PB/SA Calculations Be for Predicting Relative Binding Affinities? Ace tylcholinesterase Hu prine Inhibitors as a Test Case. . G-,P~R Theoretical Chemistry Accounts, 2001, en premsa

H. Dvir, M. Harel, X. Barril, M. Orozco, F. J. Luque, D. Muñoz-Torrero, P. Camps, T. L. Rosenberry, l. Silman, J. L. Sussman. 3D Structure of acetylcholinesterase complexed with fue novel high-affinity inhibitor huprine X, at 2.1 A resolution. Enviat per publicar

X. Barril, J. L. Gelpí, J. M. López, M. Orozco, F. J. Luque. How Accurate Can MD/LR and PB/SA Calculations Be for Predicting Relative Binding Affinities? Acetylcholinesterase Huprine Inhibitors as a Test Case. Theoretical Chemistry Accounts, 2001,106,2-9

J. L. Gelpí, X. De la Cruz, S. Kalko, X. Barril, J. Cirera, l. Fita, F. J. Luque, M. Orozco. Classical molecular interaction potentials: An improved set-up procedure in molecular dynamics simulations of proteins. Proteins; 2001, en premsa

X. Barril, M. Orozco, F. J. Luque. Towards improved acetylcholinesterase inhibitors: An structural and computational approach. Mini-Reviews in Medicinal Chemistry, 2001, 1, 255-266.

H. Dvir, M. Harel, X. Barril, M. Orozco, F. J. Luque, D. Muñoz-Torrero, P. Camps, T. L. Rosenberry, l. Silman, J. L. Sussman. 3D Structure of acetylcholinesterase complexed with fue novel high-affinity inhibitor huprine X, at 2.1 A resolution. Enviat per publicar

P. Camps, E. Gomez, D. Muñoz-Torrero, A. Badia, N. M. Vivas, X. Barril, M. Orozco, F. J. Luque. Synthesis, in vitro pharmacology and molecular modeling of syn-huprines as acetylcholinesterase inhibitors. Enviat per publicar

Batlle E, Verdz J, Dommnguez D, Llosas MM, Dmaz VM, Paciucci R, Alameda F, Garcia de Herreros A. Protein kinase C-alpha activity inversely regulates invasion of growth of intestinal cells. J Biol Chem 1998;273:15091-15098.

Santamarma A Fernandez P, Farri X, Benedit P, Reventss J, Morote J, Thomson TM and Paciucci R. PTOV-1, a novel protein overexpressed in prostate cancer,shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. The American Journal of Pathology (octubre de 2002,en premsa).

Dr  Bernardo Castellano López

Castellano B, Dalmau I, Vela JM, Acarin L, González B. Capítulo 4: Células Gliales en Condiciones Normales y Patológicas. Neuropatología. Diagnóstico y Clínica. F.F. Cruz-Sánchez (Ed.) Edimsa S.A. 2000. pag.57-111

Dalmau I, González B, Castellano B. Expression of metallothioneins I-II and ?III in the aged rat brain Glial Cell Function in Health and Disease. Barcelona 24-27 Mayo, 2000. Revista de Neurologia, p46.

Dalmau I, González B, Castellano B. Glial cellular signals after frontal sensorimotor cortex lesions in aging rats.Fens Winter School (1999): Nervous system reaction to neuronal loss and injury.

Dalmau I, González B, Castellano B. Glial cellular signals after frontal sensorimotor cortex lesions in aging rats.29th Annual Meeting Society for Neuroscience. Miami Beach, (1999) Fla. USA. Vol 25: 20.3

B. Castellano, L. Acarin, y B. González. Papel de las Células Gliales en el Envejecimiento Cerebral. En: Envejecimiento Cerebral, Alzheimer, neurodegeneración y genoma. JM Martínez-Lage y V. Hachinsky (Eds.) Triacastela (Madrid), capítulo 2. págs. 47-71.  (2001).

B. Castellano, L. Acarin, y B. González. Cambios en las células gliales del SNC durante el envejecimiento en condiciones no  patológicas. En: Envejecimiento Cerebral y Enfermedades Nerurodegenerativas Asociadas.   M.A. Peinado, M. Martínez y J.A. Pedrosa (Eds.). UNED, Centro Asociado de la Provincia  de Jaén,  capítulo 2, pags. 42-63 (2001).

Dalmau,I., González, B. and Castellano, Glial cellular signals after frontal sensorimotor cortex lesions in aging rats. B. 29th Annual Meeting Society for Neuroscience. Miami Beach, (1999) Fla, USA. Vol 25: 20.3

Dalmau,I., González, B. and Castellano Expression of metallothioneins I-II and -III in the aged brain, B. IV European Meeting on Glial Cell Function in Health and Disease, Barcelona , 2000. Revista de Neurología (Supl.2000), 46, p98, (2000)

Castillo Ruiz, MM, Acarin, L. Bonzález, B and Castellano B. Activated caspase-3 expression in glial cells after an excitotoxic lesion in the old rat brain V European Meetiing on Glial Cell Function in Health and Disease.(Euroglia 2002) Rome. Glia, Suppl 1, S22, P45 (2002)

Dr  Félix Francisco Cruz Sánchez

Dr  Arantxa Ortega Aznar

Dr  José Luis Mate Sanz

Pappolla MA. La neuropatología y la biología molecular de la enfermedad de Alzheimer.FF Cruz-Sánchez (ed.). Neuropathología. Capítulo 22:542-559, EDIMSA, S.A., Barcelona, 2000

Cruz-Sánchez FF, Ariza A. Enfermedades con acumulación de proteína priónica.FF Cruz-Sánchez (ed.). Neuropathología. Capítulo 23:561-576, EDIMSA, S.A., Barcelona, 2000

Cruz-Sánchez FF, Castejón C, Rossi M. Parkinsonism.I. FF Cruz-Sánchez (ed.). Neuropathología. Capítulo 26: 621-638, EDIMSA, S.A., Barcelona, 2000

Hartwig M, Schulz J, Ferszt R, Kühl KP, Cervós-Navarro J. Chronic activation of peripheral blood macrophages in Alzheimer's disease.Research Report. Alzheimer Reports 2: 225-229, 1999

Lafuente JV, Cervós-Navarro J. Craniocerebral Trauma Induces Hemorheological Disturbances.J Neurotrauma 16 (5):425-430, 1999

Pappolla MA, Chyan YJ, Sos M, Perry G, Smith MA, Cruz-Sánchez FF. Role of Transgenic Models for the Study of Oxidative Neurotoxicity in Alzheimer's Disease.Free Radicals in Brain Pathophysiology, New York 17: 359-382, 1999

Cruz-Sánchez FF, Cusidó M, Ruíz-Ávila L, Cejas H, Esquerda J. Patología Neuronal.FF Cruz-Sánchez (ed.). Neuropathología. Capítulo 2:21-56,EDIMSA, S.A., Barcelona, 2000

Pappolla M, Cruz-Sánchez FF. The role of melatonin in Alzheimer's disease.J Neuropathol Appl Neurobiol 25 (S1):35, 1999

Ariza A, Mate JL, Navas-Palacios JJ. Overexpression of cyclins A and B1 in JCvirus-infected cells of progressive multifocal leukoencephalopathy.Modern Pathology 1998; 11(1):158A.

Ariza A, Cruz-Sánchez FF. Enfermedades causadas por virus.En: Neuropatología. (ed). Editores Médicos SA, Barcelona, 2000; pp 347-360.

Muñoz-Mármol AM, Strasser G, Isamat M, Coulombe PA, Yang Y, Roca X, Vela E, Mate JL, Coll J, Fernández-Figueras MT, Navas-Palacios JJ, Ariza A, Fuchs E. Adysfunctional desmin mutation in a patient with severe generalized myopathy.Proceedings of the National Academy of Sciences USA 1998; 184:83-88.

Ariza A, Mate JL, Isamat M, Calatrava A, Fernández-Vasalo A, Navas-Palacios JJ. Overexpression of Ki-67 and cyclins A and B1 in JC virus-infected cells of progressive multifocal leukoencephalopathy.Journal of Neuropathology and Experimental Neurology 1998; 57(3):226-230.

Chyan J, Fernández MA, Ariza A, Cruz-Sánchez FF. Examination of the cellular dysfunction of the peripheral blood system in Alzheimers disease.Journal of Neuropathology and Experimental Neurology, 2000; 59:462.

Montoliu C, Llansola M, Yenes S, Messeguer A, Felipo V. 3,4-Dihydro-6-hydroxy-7-methoxy-2,2-dimethyl -(2H)-benzopyran (CR-6) acts as an scavenger of nitric oxide and prevents glutamate neurotoxicity in primary cultures of cerebellar neurons.Biochem. Pharmacol., 1999, 58, 255-261.

R. Hellweg, C.A. Gericke, K. Jendroska, H-D Hartung, J Cervós-Navarro. NGF Content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease. Int. J. Devl Neuroscience. Vol. 16, Nos 7/8, pp. 787-794, 1998

S. Patt, S. Danner, A. Théalliker-Jankó, G. Breier, G. Hottenrott, K.H. Plate, J. Cervós-Navarro. Upregulation of vascular endothelial growth factor in severe chronic brain hypoxia of the rat. Neurosci Lett 252: 1-4, 1998

YJ. Chyan, A. Ariza, M.A. Pappolla, F.F. Cruz-Sánchez. Neuroprotection of melatonin against Alzheimer's b peptides is independent its receptor binding activity. Neuropathol Appl Neurobiol, 26(2):194, 2000

YJ. Chyan, M.A. Pappolla, F.F. Cruz-Sánchez. Induction of NADPH cytochrome CP450 reductase by the Alzheimer amyloid b-protein. Neuropathol Appl Neurobiol, 26(2):201, 2000

M. Hartwig, J. Schulz, R. Ferszt, K.-P. Kühl, J. Cervós-Navarro. Chronic activation of peripheral blood macrophages in Alzheimer's disease. Research Report. Alzheimer Reports 2: 225-229, 1999

Chyan YJ, Ariza A, Pappolla MA, Cruz-Sánchez FF. Neuroprotection of melatonin against Alzheimer's? peptides is independent its receptor binding activity. Neuropathol & Appl Neurobiol, 26 (2): 194, 2000

Chyan YJ, Pappolla MA, Cruz-Sánchez FF. Induction of NADPH cytochrome CP450 reductase by the Alzheimer amyloid b-protein. Neuropathol & Appl Neurobiol, 26 (nº 2): 201, 2000

Cruz-Sánchez FF, Durany N, Thome J, Riederer P, Zambón D. Correlation between Apolipoprotein-E Polymorphism and Alzheimer's Disease Pathology. Journal of Alzheimer's Disease 2, 223-229, 2000

Durany N, Ravid R, Riederer P, Cruz-Sánchez FF. Increased frequency of the a-1-antichymotrypsin T allele in cerebral amyloid angiopathy. Neuropathology, 20, 184-189, 2000

Pappolla MA, Omar R, Chyan YJ, Guiso J, Hsiao K, Bozner P, Perry G, Smith M, Cruz-Sánchez FF. Induction of NADPH cytochrome P450 reductase by the Alzheimer b-protein. Amyloid as a "foreing body". Journal of Neurochemistry, 78, 121-128, 2001

Mir C, Gironès X, Murillo A, Rossi ML, Cruz-Sánchez FF. Relación entre la expresión de la p53, ki67 y la edad como parámetros biológicos para establecer la prognosis del glioblastoma. Neurología, 16(10);624. 2000

Gironès X, Ortega A, Cruz-Sánchez FF. Estudio inmunohistoquímico y del genotipo de la apolipoproteína E (ApoE) en 88 muestras cerebrales. Posible efecto del alelo e2 de ApoE en la amiloidogénesis. Neurología, 16(10);463. 2001

Cruz-Sánchez FF, Chyan YJ, Gironès X, Latorre P. La activación macrofágica y la apoptosis linfocitaria en la enfermedad de Alzheimer. Neurología, 16(10);464. 2001

Beyer K, Lao JI, Gómez M, Riutort N, Latorre P, Mate JL, Ariza A. Alzheimer disease and the cystatin C gene polymorphism: an association study. Neurosci Lett 2001; 315: 17-20

Beyer K, Lao JI, Gómez M, Riutort N, Latorre P, Mate JL, Ariza A The Th1/E47cs-G APOE promoter allele is a risk factor for Alzheimer disease of very late onset. Neurosci Lett 2002; 326:187-190

Dr  Josep Enric Esquerda Colell

Lladó J, Calderó J, Ribera J, Tarabal O, Oppenheim RW, Esquerda JE. Opposite effects of excitatory amino acids on chick embryo spinal cord motoneurons: excitotoxic degeneration or prevention of programmed cell death.Journal of Neuroscience (USA) 19:10803-10812 1999

Ayala V, Casas C, Ribera J, Calderó J, Oppenheim RW, Esquerda JE. Specific association of c-Jun.like immunoreactivity but not c-Jun p39 with normal and induced programmed cell death in the chick embryo.Journal of Neurobiology 38:171-190 1999

Tarabal O., Calderó J., Lladó J., Oppenheim R.W., Esquerda J.E. Long-lasting aberrant tubulovesicular membrane inclusions accumulate in developing motoneurons after a sublethal excitotoxicinsult: a possible model for neuronal pathology in neurodegenerative disease. The Journal of Neeuroscience, 21:8072-8081 2001

Casanovas A., Ribera J., Hager G., Kreutzberg G.WW.,Esquerda J.E. c-Jun regulation in rat neonatal motoneurons postaxotomy. Journal of Neuroscience Research 63:469-479 2001

Casas C., Ribera J., Esquerda J.E. Antibodies against c-Jun N-terminal peptide cross-react with

neo-epitopes emerging after caspase-mediated proteolysis during apoptosis. Journal of Neurochemistry 77:904-915 2001

Casanovas A., Olmos G., Ribera J., Boronat A., Esquerda JE., Gaecia-Sevilla J. Induction of reactive astrocytosis and prevention of motoneuron cell death by the I2-imidazoline receptor ligand LSL 60101 British Journal of Pharmacology 130:1767-1776 - 2000

Serrando M., Casanovas a., Esquerda JE . Occurrence of GluR1-containing aggresomes during normal development of rat spinal cord interneurons. Journal of Comparative Neurology 442:23-34 - 2000   

Lladó J., Calderó J., Ribera J., Tarabal O., Oppenheim R.W. Esquerda J.E. Oopposite effects of excitatory amino acids on chick embryo spinal cord motoneurons: excitotoxic degeneration or prevention of programmed cell death. Journal of Neuroscience. 19: 10803-10812. 

Casas .C, Ribera J, Esquerda JE .Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis. Journal of Neurochemistry (in press) 

Serrando M., Casanovas a., Esquerda JE. Occurrence of GluR1-containing aggresomes during normal development of rat spinal cord intemeurons. Journal of Comparative Neurology (març 2001 submitted)

Tarabal O., Calderó J., Lladó J., Oppenheim RW., Esquerda JE. Aberrant inclusions of tubulovesicular membranes accumulate in developing motoneurons after a sublethal excitotoxic insult. Journal of Neuroscience (març 2001, submitted).

Dr  Isidre Ferrer Abizanda

A. Tortosa, e. López, I. Ferrer. I Bcl-2 and Bax proteins in Lewy bodies from patients with Parkinson's disease and diffuse Lewy body disease.. Neurosci. Lett. 238: 78-80 (1997)

I. Ferrer, E. Martí. Distribution of fibroblast growth factor receptor-1 (FGFR-1) and FGFR-3 in the hippocampus of patients with Alzheimer's disease.. Neurosci. Lett. 240: 139-142 (1998)

I. Ferrer, E. Martí, A. Tortosa, J. Blasi. J Dystrophic neurites of senile plaques are defective in proteins involved in axocytosis and neurotransmission. Neuropathol. Exp. Neurol. 57: 218-225 (1998)

I. Ferrer, J. Ballabriga, E. Martí, E. Pozas, J. Alberch, E. Arenas. BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia. Brain Pathol. 8: 253-261 (1998)

A. Tortosa, E. López, I. Ferrer.Bcl-2 and Bax protein expression in Alzheimer's disease. Acta Neuropathol. 95: 407-412 (1998)

I. Ferrer, E. López, E. Pozas, J. Ballabriga, E. Martí. J. Comp. Múltiple neurotrophic signals converge in surviving CA1 neurons in the gerbil hippocampus following transient forebrain ischemia. Neurol. 394: 416-430 (1998)

A. Tortosa, R. Blanco, I. Ferrer Bcl-2 and Bax protein expression in neurofibrillary tangles in progressive supranuclear palsy.. NeuroReport 9: 1049-1052 (1998)

I. Ferrer, E. Martí, E. López, A. Tortosa  NF-kB Immunoreactivity is observed in association with bA4 diffuse plaques in patients with Alzheimer's disease.. Neuropathol. Appl. Neurobiol. 24: 271-277 (1998)

I. Ferrer, E. Martí, E. López, A. Tortosa . BDNF, and full-length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses.. Mol Brain Res. 59: 154-164 (1998)

F. Aguado, J. Ballabriga, E. Pozas, I. Ferrer. TrkA immunoreactivity in reactive astrocytes in human neurodegenerative diseases and colchicine-treated rats. Acta  Neuropathol. 96: 495-501 (1998)

I. Ferrer. Nuclear DNA fragmentation in Creutzfeldt-Jajob disease: does a mere positive in situ nuclear and-labeling indicate apoptosis?, Acta Neuropathol. 97: 5-12 (1999)

E. López, E. Pozas, R. Rivera, I. Ferrer. Bcl-2 and Bax expression following methylazoxymethanol acetate-induced apoptosis in the external granulle cell layer of the developing rat cerebellum. Dev Brain Res. 112: 149-153 (1999)

E. Martí, J. Blasi, I. Gómez de Aranda, r. Ribera, R. Blanco, I. Ferrer. Selective early induction of synaptosomal-associated protein (molecular weight 25,000) following systemic administration of kainate at convulsant doses in the rat. Neuroscience 90: 1421-1432 (1999)

E. Martí, i. Ferrer, J. Blasi. Transient increase of synapsin-I immunoreactivity  in the mossy  fiber layer of the hippocampus after transient forebrain ischemia in the Mongolian gerbil. Brain Res. 824: 153-160 (1999)

B E. López, E. Pozas, R. rivera, I. Ferrer. cl-2, Bax and BclX expression following kainic acid administration at convulsant doses in the rat. Neurosciente 91: 1461-1470 (1999)

I. Ferrer, r. Rivera, R. Blanco, E. Martí. Expression of proteins linked to exocytosis and neurotransmission  in patients with Creutzfeldt-Jakob disease. Neurobiol. Dis. 6: 92-100 (1999)

I. Ferrer. Neurons and their dendrites in frontotemporal dementia.. Dement. Geriat. Cogn. Dis. 10 (suppl 1) : 55-60 (1999)

I. Ferrer, C. Marín, M. J. Rey, T. Ribalta, E. Goutan, R. Blanco, e. Tolosa, E. Martí. BDNF and Full-length and Truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J. Neuropathol. Exp. Neurol. 58: 729-739 (1999)

I. Ferrer, E. López, R. Blanco, R. Rivera, J. Krupinsky, E. Martí. Differential c-Fos and caspase expression following kainic excitotoxicity Acta Neuropathol 99: 245-256 (1999)

Brain-derived neurotrophic factor in frontotemporal dementia. I. Ferrer, C. Marín, M. J. Rey, T. Ribalta. Neurosci. Lett 279: 33-36 (1999)

J Krupinski, E. Lopez, E. Martí, I. Ferrer Expression of caspases and their substrates in the rat model of focal cerebral ischemia.. Neurobiol Dis 7: 332-342 (2000)

I. Ferrer, R. Blanco, M. Carmona, B. Puig, R.Ribera, MJ Rey, T. Ribalta. Prion protein expression in senile oplaques in Alzheimer's disease. Acta Neuropathol 101:49-56 (2001)

E. Martí, I. Ferrer, J. Blasi Differential regulation of chromogranin A, chromogranin B and secretoneurin protein expression after transient forebrain ischemia in the gerbil.. Acta Neuropathol 101: 159-166 (2001)

I. Ferrer, J. Krupinski, E. Goutan, E. Martí, S. Ambrosio, E. Arenas Brain-derived neurotrophic factyor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat.. Acta Neuropathol 101:229-238 (2001)

Dr  Maria Pia Gallano Petit

Lasa A, Piccolo F, de Diego C, Jeanpierre M, Colomer J, Rodríguez MJ, Urtizberea JA, Baiget M, Kaplan JC, Gallano P.Severe limb girdle muscular dystrophy in Spanish gypsies: further evidence for a founder mutation in the g-sarcoglycan gene. Eur J Hum Genet 1998;6:396-399.

Urtasun M, Poza JJ, Gallano P, Lasa A, Sáenz A, Cobo AM, Leturcq F, López de Munain A, García-Bragado F Distrofia muscular por déficit de la subunidad alfa-sarcoglicano del complejo de proteínas relacionadas con la distrofina.. Med Clin (Barc) 1998;110:538-542.

Gallano P, Lasa A, de Diego C, Baiget M. Las distrofinopatías: aspectos clínicos, histológicos y moleculares. Diagnóstico molecular en Genética Médica. Seqc Editores 1998. Págs: 37-60.

Gallano P, Lasa A, de Diego C, Rodríguez MJ, Baiget M. Clasificación genética de las distrofinopatías. Asem (Revista de la Asociación Española de Enfermedades Musculares) 1998;38:24-26.

López de Munain A, Urtasun M, Poza JJ, Ruiz J, Sáenz A, Cobo AM, Lasa A, Gallano P, Baiget M, Martí-Massó JF Alteraciones en las proteínas funcionales. Déficit de calpaína 3.. Rev Neurol 1998, 28:158-164.

L  Anderson, K Davison, J Moss, I Richard, M Fardeau, F Tomé, C Hübner, A Lasa, J Colomer, J Beckmann. Characterization of monoclonal antibodies to Calpain 3 and protein expression in muscle from patients with lim-girdle muscular dystrophy type 2ª. Am J Pathol 1998, 153:1169-1179.

Richard I, Roudaut C, Saenz A, Pogue R, Grimbergen J, Anderson L, Beley C, Cobo AM, de Diego C, Eymard B, Gallano P, Ginjaar H, Lasa A, Pollit C, Topaloglu H, Urtizberea JA, de Visser M, van der Kooi A, Bushby K, Bakker E, López de Munain A, Fardeau M, Beckmann J. Calpainopathy: A survey of mutations and polymorphisms. Am J Hum Genet 1999, 64:1524-1540.

Nov C de Diego, J Gámez, E Plassart-Schiess, A Lasa, E del Río, C Cervera, M Baiget, P Gallano, B Fontaine Cel mutations in the muscle chloride channel CLCN1 gene causing myotonia congenita in Spanish families.. J Neurol 1999, 080.1-5.

P Gallano, A Lasa, C de Diego, O Díez, M Baiget Bases moleculars de les distròfies musculars progresives.. Patologia molecular (R. Bartrons , ed) Vol 49 (1999) 193-206. ISSN: 0212-3037.

M Baiget, P Gallano, E Tizzano. Diagnóstico prenatal molecular de enfermedades hereditarias. Topicos en Neonatologia, pags 1-12. Easo Eds. ISBN 84-605-8722-3.

Merlini L, Kaplan JC, Navarro C, Barois A, Bonneau D, Brasa J, Echenne B, Gallano P, et al Homogeneous phenotype of the gypsy limb-girdle MD with the g-sarcoglycan C283Y mutation.. Neurology 2000, 54:1075-1079.

Illa I, Serrano C, Lasa A, gallardo E, Rojas-garcía R, Palmer J, Gallano P, Baiget M, Brown Distal anterior compartment myopathy: a dysferlin mutation causing a new muscular dystal phenotype. RH. Annals Neurol 2001, 49:130-134.

Gallano P, Lasa A, de Diego C, Illa I, Colomer J, Serrano C, Baiget M Genetic and clinical analysis of autosomal recessive LGMD in Spanish families.. Neuromusc Disord 1998;8:277.

Illa I, Serrano C, Gallardo E, Barraquer L, Lasa A, Gallano P, Baiget M, Bajaoui K, Brown Distal anterior compartment myopathy: a new severe dystrophic phenotype linked to chromosome 2p13. RH. Neurology 1998;50:186.

Merlini L, Barois A, De Monte A, Echenne B, Gallano P, Jarre L, Kalaydjieva L, Levy-Gomes A, Navarro C, Toutain A, Turner I, Urtizberea A, Vallet JM, Voit T, Warter JM, Kaplan JC Limb-girdle muscular dystrophy 2C with C283Y mutation in Gypsies: characterization of the clinical phenotype.. Neurology 1998;50:137- 138.

Gallano P, Sáenz A, Urtasun M, de Diego C, Cobo AM, Baiget M, López de Munain A, Lasa A. Autosomal recessive LGMD in Spanish families: a clinical, immunochemical and genetic analyses. Eur J Hum Genet 1998;6,suppl:122.

Gámez J, de Diego C, Cervera C, Plassart E, Lasa A, Baiget M, Fontaine B Novel mutations in four Spanish families with Myotonia Congenita. Journal of Neurology 1998;245,6/7:408.

P Gallano, A López de Munain Calpainoainopathies in Spain, The Spanish study.. Acta Myologica 1999, 3:55-56.

A Lasa, C de diego, E Gallardo, MJ Rodríguez, E del Río, J Colomer, I Illa, M Baiget, P Gallano. The mutational spectrum of sarcoglycanopathies in Spanish families. Acta Myologica 1999, 3:88.

J Colomer, C Iturriaga, A Lasa, J Vila, J Corbera Structural protein interaction and clinical findings in patients affected from sarcoglycan deficiency.. Acta Myologica 1999, 3: 89.

J Colomer, C Iturriaga, A Lasa, L Anderson Clinical and protein expression in LGMD2A (Calpain 3 deficiency).. Acta Myologica 1999, 3: 92.

A Sáenz, C de Diego, A Cobo, A Lasa, M Rodríguez et al Calpain deficiency in Spain and Aquitania.. Acta Myologica 1999, 3:93.

Dr Agustina García Sánchez

Baltrons MA, García A. Nitric Oxide-Independent Down-Regulation of Soluble Guanylyl Cyclase by Bacterial Endotoxin in Astroglial Cells.J. Neurochem. 73, 2149-2157 (1999)

Baltrons, M. A., García, A. The nitric oxide/cyclic GMP system in astroglial cells. In Progr. Brain Res. (Eds. B. Castellano and M. Nieto-Sampedro). Vol. 132, pp. 335-347, Elsevier Sci. 2001

Espejo, C., Carrasco, J., Hidalgo, J., Penkowa, M., García, A., Montalban, X., Martínez-Cáceres, E.M. . Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis. Neuroscience, 105:1055-65, 2001

Pedraza, C.E., Baltrons, M.A., García, A.. Interleukin-1b stimulates cGMP efflux in astroglial cells . FEBS Letters 507:303-306, 2001

Baltrons M.A., Pedraza CE., García A.. Down-regulation of soluble guanylyl cyclase by ß-amyloid peptides in astroglial cells. Revista de Neurología 24-27th, 40 May 2000

Sardón T, Baltrons M.A.,García A.. Inhibition of the soluble guanylyl cyclase of astroglial cell by long term exposure to nitric oxide. Revista de Neurología 24-27th, 40 May 2000

Pedraza CE., Baltrons M.A.,García A.Effect of inflammatory cytokines on nitric oxide-dependent cyclic GMP formation in rat cerebelllar astrocytes. Revista de Neurología 24-27th, 40 May 2000

Baltrons M.A., Pedraza CE., García A.. ß-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells. J. Neurochem. 78, 137, 2001

Dr  Carmen Garcia Sánchez

Boltes, A., García-Sánchez, C., Gironell, A., Otermín, P., Pascual-Sedano, B., Estévez-González, A. & Kulisevsky, J. Marcadores neurofisiológicos precoces en el deterioro cognitivo. LII Reunión ANual de la Sociedad Española de Neurología. Diciembre, Barcelona. Neurologia, 15(10):541-542. (2000).

García-Sánchez C., Estévez-González A., Boltes A., Otermín P., Pascual-Sedano B., Gironell A. & Kulisevsky J   LIII Reunión Anual de la Sociedad Española de Neurología. Diciembre, Barcelona. Neurologia, 16:524. . (2001).

Boltes, A., García-Sánchez, C., Gironell, A., Baiget, M., Otermín, P., Pascual-Sedano, B., Estévez-González, A. & Kulisevsky, J El genotipo ApoE y los trastornos de Memoria. LIII Reunión Anual de la Sociedad Española de Neurología. Diciembre, Barcelona. Neurologia, 16:541-542 . (2001).

Estévez-González, A. & García-Sánchez, C Reaction time: an easy pc-compatible programme. 22nd. Annual Mid-year Conference of the INTERNATIONAL NEUROPSYCHOLOGICAL  SOCIETY. Durban (South Africa), June 22-26. Journal of the International Neuropsychological Society, 5:280. (1999).

Estévez-González, A., Kulisevsky J. Boltes A.,  Rami  L., Fuentes  N & García-Sánchez  C. MMSE and memory performance in subjects with subjective memory complaints. 23rd. Annual Mid-year Conference of the INTERNATIONAL NEUROPSYCHOLOGICAL  SOCIETY. Brussels, Belgium, July 12-15. Journal of the International Neuropsychological Society, 6:416-417. (2000).

García-Sánchez C.,  Kulisevsky J.,  Boltes   A., Otermín P., González E. & Estévez-González, AA differential memory profile in patients with subjective memory complaints and normal mmse score: Depression or cognitive decline?. World Alzheimer Congress 2000, Washington, July 8-14. Neurobiology of Aging, 21 (1S): S157. . (2000).

Estévez-González, A.,  García-Sánchez  C., Boltes A., Otermín, P. & Kulisevsky J.   Incidental memory in thepreclinical phase of Alzheimer's disease. 24th. Annual Mid-year Conference of the INTERNATIONAL NEUROPSYCHOLOGICAL  SOCIETY. Stockholm, Sweden, July. Journal of the International Neuropsychological Society, 8:490.  (2002).

Dr  Josep Maria Grau Veciana

Dr  Francisca Vidal Domínguez

Dr  Nicolau Ortiz Castellon

Willison HJ, Veitch J, Swan AV, Baumann N, Comi G, Gregson NA, Illa I. Inter-laboratory validation of an ELISA for the determination of serum anti-ganglioside antibodies.Eur J of Neurol. 1999; 6:71-77.

Gallardo E, Rojas R, Serrano-Munuera C, Ortiz N, Álvarez Cermeño JC, Baiges JJ, Combarros O, Illa I. Anticuerpos anti-GD1a en el síndrome de Guillain-Barré.Neurología 1999; 14(10): 500.

Tizzano E, Rojas R, Lleó A, Barceló MJ, Cuscó I, Armán M, Illa I, Baiget M. Estudio de la asociación de la neuropatía motora multifocal (NMM) y la enfermedad difusa de la 2ª motoneurona (LMND) con la deleción homocigota del gen SMN centromérico.Neurología 1999; 14(10): 511.

Gallardo E, Rojas R, Illa I. Anticuerpos relevantes en neuropatías disinmunes.Rev Neurol 2000; 30(6): 510-514.

INCAT group. Fatigue in immune-mediated polyneuropathies.ISJ Merkies Neurology. 1999; 53: 1648-1654

Ortiz N, Rosa R, Illa I, Gallardo E, Masana L. Inmunoreactividad contra gangliósidos minoritarios en suero de pacientes con enfermedades neuromusculares.Neurologia 1999; 14:566

Bassols A, Bosch F, Campillo M, Cañellas M, Baños JE. An epidemiological comparison of pain complaints in the general population of Catalonia (Spain).Pain, 83, 9-16 (1999)

Giraldo J. The slope parameter and the receptor reserve.Trends in Pharmacological Science 19, 445 (1998)

Pardo L, Sepulcre F, Cladera J, Duñach M, Labarta A, Tejada J, Padrós E. Experimental and theoretical characterization of the high affinity cation binding site of the purple membrane.Biophysical Journal, 75, 777-784 (1998)

Tabernero A, Giraldo J, Vila E. Modelling the changes due to the endothelium and hypertension in the alpha-adenoreceptor-mediated responses of rat aorta.Journal of Autonomic Pharmacology, 19, 219-228 (1999)

Guitart M, Giraldo J, Goñalons E, Vila E, Badia A. Adrenergic and purinergic components in bisected vas deferens from spontaneously hypertensive rats.British Journal of Pharmacology, 128, 873-880 (1999)

Giraldo J. A pH-Dependent Model of the Activation Mechanism of the Histamine H2-Receptor.Biochemical Pharmacology, 58, 343-353 (1999)

Ortiz N, Rosa R, Gallardo E, Illa I, Tomas J, Aubry J, Santafe M. IgM monoclonal antibody against terminal moiety of GM2, GalNAc-GD1a and GalNAc-GM1b from a pure motor chronic demyelinating polyneuropathy patient: effects on neurotransmitter release. J Neuroimmunol 2001;119(1):114-23.

O'Hanlon G, Veitch J, Gallardo E, Illa I, Chancellor AM, Willison HJ.Peripheral neuropathy with anti-GM2 ganglioside antibodies: clinical and immunopathological studies Autoimmunity 2000; 32:133-144.

Illa I, Gallardo E, Rojas R. et al Chronic idiopathic ataxic neuropathy: immunological aspects of a series of seventeen patients. Rev Neurol (Paris). 2001 May;157(5):517-22.

R. Rojas, E Gallardo, C Roig, et al Anti-GQ1b antibodies: usefulness of its detection for the diagnosis of Miller-Fisher syndrome. Med Clin (Barc). 2001 Jun 2;116(20):761-764.

E Gallardo, R Rojas, R Belvis et al Antiganglioside antibodies: when, which and what for. Neurología. 2001 Agosto 16: 293-297

RH Hughes, S Bensa, HJ Willison P Van den Bergh, G Comi, I Illa et al Randomized controlled trial of intravenous immunoglobulin versus oral predinisolone in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol. 2001 50: 195-201.

C Gómez-Moutón, JL Abad, E. Mira, RA Lacalle, E Gallardo et al. Segregation of leading edge and uropod components into specific lipid rafts during T cell polarization. Proceedings National Academy of Science 2001 August 98(17): 9642-9647.

C. Serrano, E. Gallardo, R. Rojas, N. De Luna, A González, JF Martí, A Martinez, R Reñé, J Berciano, JM Grau, HJ Willison, F Graus, I Illa. Antiganglioside antibodies in acute self-limiting ataxic neuropathy: incidence and significance. J Neuroimmunol 2001 120: 78-83.

JL Molinuevo, F Graus, C Serrano, R Reñé, A Guerrero, I Illa. Utility of anti_Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy Ann Neurol 1998 44: 976-980

Gallardo E, Serrano C, J Coll, JA Matos, C Arnal, R. Vilches, J Forcadas, A López, JM Polo, J Berciano, F Costa-Jussa F Castellanos, P. Villanueva, I Illa Anticuerpos anti-GQ1b en el síndrome de Miller-Fisher: una serie española de esta asociación clínico patológica.. Presentat a la XLIX reunió anual de la SEN Barcelona 1997. Neurología vol 12 num 10 pag 443 1997

Acute self-limiting ataxic neuropathy (¨Sensory Guillain-Barré syndrome¨): looking for antigangliosides antibodies. Journal of Neurology vol 245 (6/7): 416, 1998.

N. Ortiz, R. Rosa, E. Gallardo, M. Sabaté, J. Tomás, J. Aubry, l. lila, M. Santafé. IgM Monoclonal antibody against GM2, GaINAc-GD1 a and GaINac-GM1 b from a CIDP patient can affect neurotransmitter release. J. Neuroimmnunol, Acceptat per a la seva publicació

Dr  Francesc Graus Ribas

Graus F, Keime-Guibert F, Reñé R, Benyahia B, Ribalta T, Ascaso C, Escaramis G, Delattre JY. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 2001;124:1138-1148

Saiz A, Carreras E, Berenguer J, Yagüe J, Martínez C, Marín P, Rovira M, Pujol T, Arbizu T, Graus F. MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS. Neurology 2001;56:1084-1089

Bernal F, Graus F, Pifarré A, Saiz A, Benyahia B, Ribalta T. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta Neuropathol 2002;103:509-515

Fassas A, Passweg JR, Anagnostopoulos A, Kazis A, Kozak T, Havdrova E, Carreras E, Graus F, et al. Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study. J Neurol 2002; 249:1088-1097.

Dr  Dolores Jaraquemada Pérez de Guzmán

M. COSTA, A. SAIZ, R. CASAMITJANA, M. FERNANDEZ CASTAÑER, A. SANMARTÍ, F. GRAUS,  D. JARAQUEMADA.T-cell reactivity to glutamic acid decarboxylase in stiff-man syndrome and cerebellar ataxia associated with polyendocrine autoimmunity. CIin Exp Irnmunol 2002; 129:471-478 

Dr  Albert J. Jovell Fernández

Aymerich M, Jovell AJ, Guillamón I. Características socio-demográficas, de discapacidad y de salud percibida de los pacientes de esclerosis múltiple y sus familiares.(submitted)

Aymerich M, Jovell AJ, Guillamón I. A Cost-Effectiveness Analysis of Relapsing-Remitting Multiple Sclerosis Therapies.(submitted)

Dr  Jaume Kulisevsky Bojarski

Pascual-Sedano B, Gironell A, Molet J, Parés P, Kulisevsky J. Resultados de la cirugia funcional de la enfermedad de Parkinson en una serie de 30 pacientes.Neurologia, Vol. 15 No 5 Mayo 2000, 243

Kulisevsky J, García-Sánchez C, Berthier ML, Barbanoj M, Pascual-Sedano B, Gironell A, Estévez-González A. Chronic Effects of Dopaminergic Replacement on Cognitive Function in Parkinsons Disease: A Two-Year Follow-Up Study of Previously Untreated Patients.Movement Disorders Vol. 00 No. 0, 2000, p.000-000 © Movement Disorder Society

Kulisevsky J. Role of dopamine in learning and memory: Implications for the treatment of cognitive dysfunction in patients with Parkinsons disease.Drugs & Aging 2000; 16:365-379.

Gironell A, Pascual-Sedano B, Molet J, Parés P, Kulisevsky J. Resultats de la cirurgia funcional de la malaltia de Parkinson en una sèrie de 30 pacients.IV Reunió de Neuròlegs catalans. Societat Catalana de Neurologia. Revista de Neurología 2000; 30: 17-18.

Roig C, Gironell A, Pascual B, Kulisevsky J. Estudio de la cirugia palidal sobre la oculomotricidad en la enfermedad de Parkinson. Estudio preliminar.LI Reunión anual de la Sociedad Española de Neurología. Barcelona. Desembre 1999. Neurología 1999; 14: 525.

Gironell A, Pascual-Sedano B, Molet J, Parés P, Kulisevsky J. Ganancia ponderal despues de la cirugia funcional del núcleo palido en la enfermedad de Parkinson.Neurologia, Vol. 15 No 5 Mayo 2000, 243

J.Kulisevsky, A.Lleó, A.Gironell, J.Molet, B.Pascual, P.Parés. Bilateral pallidal stimulation for cervical dystonia: dissociated pain and motor improvement. Neurology 2000; 55: 1754-1755

J.Kulisevsky, A.Gironell, J.Molet  Deep-Brain Stimulation for Parkinson's Disease Study Group J). Deep-brain stimulation fo the subthalamic nucleus or the pars interna of the globus pallidus in Pakinson's disease. The New England Journal of Medicine 2001; 345:956-963

J.Kulisevsky, M.L.Berthier, A.Gironell, B.Pascual-Sedano, J.Molet, P.Parés. Secondary mania following subthalamic nucleus deep brain stimulation for the treatment of Parkinson's disease. 53 Annual Meeting of the American Academy of Neurology. Philadelphya, USA, abril 2001. (Neurology 2001; 56 (supl. 3): A49).

J.Kulisevsky, B.Pascual-Sedano, M.L.Berthier, A.Gironell, J.Molet, P.Parés. Manía secundaria a estimulación del núcleo subtalámico para el tratamiento de la enfermedad de Parkinson.  LIII Reunión Anual de la Sociedad Española de Neurología. Barcelona, Desembre de 2001. (Neurología 2001:16:476).

B.Pascual-Sedano, C.García-Sánchez, A.Gironell, A.Boltes, M.Berthier, M.Barbanoj, J.Kulisevsky. A double-blind comparative study of the acute effects of levodopa and bilateral globus pallidus stimulation on frontal neurophychological performance in Parkinson's disease. 51 th Annual Meeting of the American Academy of Neurology. Toronto. Abril 1999. (Neurology 1999; 52: A514).

A.Gironell, C.García-Sánchez, B.Pascual-Sedano, J.Molet, J.Kulisevsky. Cognitive outcome following pallidotomy for Parkinson's disease: a controlled study. Sixth International Congress of Parkinson's disease and Movement Disorders. Barcelona, juny 2000. (Movement  Disorders 2000; 15 (Supl. 3):59.

J.C.Martín, A.Gironell, A.Catafau, A.Tembl, C.Marí, A.Flotats, Ll.Berná, M.Estorch, I.Carrió. SPECT cerebral de activación motora en la evaluación del tratamiento quirúrgico de la enfermedad de Parkinson. XXI congreso de la Sociedad Española de Medicina Nuclear. Tenerife, maig 2000. (Revista Española de Medicina Nuclear 2000;19:143).

B.Pascual-Sedano, A.Gironell, A.Boltes, P.Otermin, A.Catafau, J.Molet, J.Kulisevsky. Estudio con HMPAO SPECT de la reorganización del área motora suplementaria tras cirugía palidal en la enfermedad de Parkinson. . LII Reunión Anual de la Sociedad Española de Neurología. Barcelona, Desembre de 2000. (Neurología 2000: 15: 580).

A.Gironell, J.Kulisevsky, B.P.Sedano, J.Molet. Effects of internal globus pallidus stimulation on motor cortex excitability. Neurology 2002;58:669-670.

A.Gironell, A.Rodríguez-Fornells, J.Kulisevsky, B.Pascual, M.Barbanoj, P.Otermin. Motor circuitry re-organization after pallidotomy in Parkinson's disease: a neurophysiological study of the bereitschaftspotential, contingent negative variation and N30. Journal of Clinical Neurophysiology 2002; primera revisió

C.Roig, A.Gironell, B.Pascual, J.Kulisevsky. Estudio de la cirugia palidal sobre la oculomotricidad en la enfermedad de Parkinson. Estudio preliminar. LI Reunión anual de la Sociedad Española de Neurología. Barcelona. Desembre 1999. (Neurología 1999; 14: 52). 

C.Roig, B.Pascual-Sedano, A.Gironell, J.Molet, J.Kulisevsky. An acute study of the oculomotor response to deep brain stimulation in Parkinson's disease. Sixth International Congress of Parkinson's disease and Movement Disorders. Barcelona, juny 2000. (Movement Disorders 2000; 15 (Supl. 3): 50.

A.Gironell, B.Pascual, J.Molet, P.Pares, Kulisevsky. Ganancia ponderal después de la cirugia palidal en la enfermedad de Parkinson. Reunión extraordinaria de la Sociedad Española de Neurología. Granada, maig 2000. (Neurología 2000; 15: 450).

J.Kulisevsky, A.Gironell, J.Molet, dins el Grupo de Estudio de estimulación cerebral profunda en la enfermedad de Parkinson. Estimulación palidal y subtalámica en la enfermedad de Parkinson: enseñanzas de los malos resultados. Neurología 2001; 16: 298-302.

Kulisevsky J, García-Sánchez C, Berthier ML, Barbanoj M, Pascual-Sedano B, Gironell A, Estévez-González A, Chronic effects of dopaminergic replacement on cognitive function in Parkinson's disease: two-year follow-up study of previously untreated patients. Movement Disorders 2000;15:613-626.

Kulisevsky J. Role of dopamine in learning and memory: Implications for the treatment of cognitive dysfunction in patients with Parkinson's disease. Drugs & Aging 2000;16:365-379.

Dr  Joan Martí Fàbregas

Martí Fàbregas J, Valencia C, Lópea Contreras J, Roca-Cusachs A, Solé MJ, García-Sánchez C, Martí-Vilalta JLL. Blood pressure variability in Binswanger's disease and isolated lacunar infarction" Cerebrovascular diseases - Cerebrovasc Dis 2001;11:230-234

Martí-Fabregas J, Valencia C, Pujol J, GarcÍa-Sánchez C, Roca-Cusachs J. , López-Contreras J, Solé MJ, Martí-Vilalta J-L. Blood pressure variability and leukoaraiosis amount in cerebral small-vessel disease. Acta Neurol Scand 2001: 104: 358-363. ([) Munksgaard 2001.

Martí-Fàbregas J, Valencia C, Mendoza G, López-Contreras J, Roca A, García C, Solé MJ, Martí-Vilalta JL. Variabilidad de la presión arterial en pacientes hipertensos con enfermedad cerebral de pequeño vaso. LI Reunión Anual de la Sociedad Española de Neurología, Barcelona, desembre del 1999 Neurología 1999;14:47

J. Martí-Fàbregas, J. López-Contreras, C. Valencia, G. Mendoza, C. García, M.J. Solé, A.Roca-Cusachs, J.L. Martí-Vilalta. Ambulatory Blood Pressure (ABP) variability is not increased in patients with Bisnwanger's disease (BD). VIII European Stroke Conference (abril, 1999). Cerebrovascular diseases 1999;9(suppl 1):1-128

J. Martí-Fàbregas, C. Valencia, J. Pujol (*), C.García, J-L. Martí-Vilalta. Asociación entre fibrinógeno y leucoaraiosis en la enfermedad cerebral de pequeño vaso. LII Reunión Anual de la Sociedad Española de Neurología, desembre del 2000 a Barcelona Neurología 2000;15:426.

C. Valencia, J. Martí-Fàbregas, J. Pujol (*), C.García, J-L. Martí-Vilalta. Análisis comparativo de la leucoaraiosis en la enfermedad de Alzheimer, la enfermedad de Binswanger y los infartos lacunares. LII Reunión Anual de la Sociedad Española de Neurología, desembre del 2000, a Barcelona Neurología 2000;15:424

Valencia C, Martí-Fàbregas J, García-Sánchez C, Pujol J, Boltes A, Martí-Vilalta JL. Metabolite differences in patients with Alzheimer's disease, Binswanger's disease, and lacunar infarct. Study with 1H magnetic resonance spectroscopic imaging. 10th European Stroke Conference, Lisboa, maig de 2001. Cerebrovasc Dis 2001;11(suppl 4):29.

Martí-Fàbregas J, Valencia C, Pujol J, García-Sánchez C, Martí-Vilalta JL. Are fibrinogen and hematocrit associated with the amount of leukoaraiosis in cerebral small-vessel disease? 10th European Stroke Conference, Lisboa, maig de 2001. Cerebrovasc Dis 2001;11(suppl 4):99.  

J. Martí-Fabregasa, C. Valencia, J. Pujol, C. García-Sáncheza, .J.LL. Martí-Vilalta Fibrinogen and the Amount of leukoaraiosis in Patients with Symptomatic Small-Vessel Disease. Eur.Neurol 2002;48: 185-190

Dr  Emili Martínez Hermida

A. Melani, C. Corsi, L. Giménez, E. Martínez, S.O. Ogren, F. Pedata, S. Ferré. Effect of N-methyl-D-aspartate on motor activity and in vivo adenosine striatal outflow in the rat.. Europ. J. Pharmacol. (1999) 385: 15-19.

A. Melani, C. Corsi, L. Giménez, E. Martínez, S.O. Ogren, F. Pedata, S. Ferré. Adenosine A2A and group I metabotropic glutamate rceptors  synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum.. Neuropharmacology (1999) 38: 129-140.

Vivó M, de Vera N, Cortés R, Mengod G, Camón L, Martínez E. Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders.. Neuroscience Letters (2001) 304: 107-111.

L. Camón,  N. de Vera and E. Martínez.. Polyamines metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain. J. Neurosci. Res. (2001) 66:1101-1111.

Z. Díaz-Cabiale, M. Vivó, A. del Arco, W. T. O'Connor,  M. K. Harte,  C. E. Müller, E. Martínez, P. Popoli, K. Fuxe and S. Ferré Metabotropic glutamate mGlu5 receptors-mediated modulation of the ventral striatopallidal GABA pathway in rats. Interactions with adenosine A2A and dopamine D2 receptors. Neuroscience Letters (2002) 324: 154-158.

Vera N, Camón L, Martínez E. Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. Europ Neuropsychopharmacol (2002) 12:397-405.

Vivó M, Camón L, de Vera N, Martínez E. Extracellular putrescine content after acute excitotoxic brain damage in the rat.. Neurosci Letters (2002) 330: 74-78.

M. Vivó, L. Carnón, N.de Vera, E. MartÍnez . Lesion of substantia nigra pars compacta by the GluR5 agonist ATPA. Brain Research 955 (2002) 104-114

Dr  Guadalupe Mengod Los Arcos

Pérez-Torres S, Miró X, Palacios JM, Cortés R, Puigdomènech P, Mengod G. Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography. Comparison with monkey and rat brain. Journal of Chemical Neuroanatomy 20 (2000) 349-374.

Miró X, Perez-Torres S, Palacios JM, Puigdomènech P, Mengod G. Differential distribution of cAMP phosphodiesterase 7A mRNA in rat brain and peripheral organs. Synapse 40 (2001) 201-214.

Miró X, Casacuberta JM, Gutierrez-Lopez MD, Ortiz de Landázuri M, Puigdomènech P. Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha. Biochem Biophys Res Commun. 274 (2000)415-21.

X. Miró, S. Pérez-Torres, J.M. Palacios, P. Puigdomènech, G. Mengod. cAMP-specific phosphodiesterases PDE4, PDE4D splice variants and PDE7A: Differential regulation following acute systemic inflammatory response in rat brain. Society for Neuroscience Abstracts, 26 (2000) 1937

S. Pérez-Torres, X. Miró, R. Cortés, J.M. Palacios, G. Mengod. Anatomical distribution of cAMP phosphodiesterases PDE4 in human brain and comparison with other species. Society for Neuroscience Abstracts, 26 (2000) 1937.

S. Pérez-Torres, R. Cortés, M. Tolnay, A. Probst,  G. Mengod. Cellular expression of cAMP phosphodiesterase PDE4A, PDE4B  and PDE4D mRNAs in Alzheimer's disease brains. Society for Neuroscience Abstracts. 2001

Miró X., Perez- Torres, S., Puigdomenech P, and Mengod, G. Differential distribution of PDE4D splice variant mRNAs in rat brain. Molecular Brain Research. (Submitted). J

Pérez- Torres, S., Miró X., Artigas F., Palacios JM., Puigdomenech P., Mengod G. Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study. Molecular Brain Research. (Submitted). 

Perez- Torres, S., Miró X., Puigdomenech P, and Mengod, G. cAMP-specific i Phosphodiesterases PDE4, PDE4D splice variants and PDE7 A: Differential regulation of their mRNAs following acute systemic inflammatory response in rat brain. 

F. Azorín, J. Seleta, C. Sonet, J.M. Casacuberta, T. Doménech, M. Miralpeix, X. Miró, J.M. Palacios, S. Piña, P. Puigdomenech & H. Ryder. Pharmacological characterization of human phosphodiesterase 4 (PDE4) isoenzymes A, S, C and D. (in preparation)

Dr  Angel Messeguer Peipoch

Dr  Vicente Felipó Orts

Montoliu C, Llansola M, Yenes S, Messeguer A, Felipó V. 3,4-Dihydro-6-hydroxy-7-methoxy-2,2 dimethyl-(2H)-benzopyran (CR-6) acts as an scavenger of nitric oxide and prevents glutamate neuroxicity in primary cultures of cerebellar neurons.Biochem. Pharmacol. 1999, 58, 255-261.

Miñana MD, Corbalán R, Montoliu C, Teng CM, Felipó V. Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes. A putative peripheral marker for neurological alterations.Biochem. Biophys. Res. Commun. 257, 405-409 1999

Llansola M, Hermenegildo C, Miñana MD, Felipó V. Carbachol-induced hydrolysis of phospholipids in hippocampal slices may be mediated in part by subsequent activation of metabotropic glutamate receptors.Neurochem. Res. 23, 915-920 1998

Llansola M, Monfort P, Felipó V. Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons.J. Pharm Exp Ther. 292, 870-876 2000

Monfort P, Montoliu C, Hermenegildo C, Muñoz MD, Felipó V. Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors.Neurochem. Int.

Hermenegildo C, Monfort P, Felipó V. Activation of NMDA receptors in rat brain in vivo following acute ammonia intoxication. Characterization by in vivo brain microdialysis.Hepatology

Aguilar MA, Miñarro J, Felipó V. Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats.Experimental Neurol 161, 704-713 2000

Sáez R, Llansola M, Felipó V. Chronic exposure to ammonia alters pathways modulating phosphorylation of the microtubule-associated protein MAP-2 in cerebellar neurons in culture.J. Neurochem. 73, 2555-2562 1999

Llansola M, Miñana MD, Montoliu C, Sáez R, Corbalán R, Manzo L, Felipó V. Prenatal exposure to aluminium reduces expression of neuronal nitric oxide synthase and of soluble guanylate cyclase and impairs glutamatergic neurotransimission in rat cerebellum.J. Neurochem. 73, 712-718 1999

Muñoz MD, Monfort P, Gaztelu JM, Felipó V. Hyperammonemia Impairs NMDA Receptor-Dependent Long-Term Potentiation in the CA1 of Rat Hippocampus in vitro.Neurochem Res 25, 437-441 2000

Llansola M, Felipó V. Carnitine inhibits hydrolysis of inositol phospholpids induced by activation of metabotropic receptors.Neurochem. Res 23, 1533-1537 1998

Montoliu C, Llansola M, Kosenko E, Corbalán R, Felipó V. Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons.Neuropharmacology 38, 1883-1891 1999

Miñana MD, Montoliu C, Felipó V. A new reliable procedure for quantification of glutamate neurotoxicity in large number of samples.Anal. Pharmacol. 1, 36-42 1999

Hermenegildo C, Montoliu C, Llansola M, Muñoz MD, Gaztelu JM, Miñana MD, Felipó V. Chronic hyperammonemia impairs glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo.Eur. J. Neurosci. 10, 3201-3209 1998

Miñana MD, Montoliu C, Llansola M, Grisolía S, Felipó V. Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons.Neuropharmacology 37, 847-857 1998

Felipó V, Hermenegildo C, Montoliu C, Llansola M, Miñana MD. Neurotoxicity of ammonia and glutamate: Molecular mechanisms and prevention.NeuroToxicology 19, 675-682 1998

Kosenko E, Kaminski Y, Lopata O, Muravyov N, Felipó V. Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication.Free Rad. Biol. Med. 26, 1369-1374 1999

Hermenegildo C, Sáez R, Minoia C, Manzo L, Felipó V. Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo.Neurochem. Int. 34; 245-253 1999

Montoliu C, Llansola M, Sáez R, Yenes S, Messeguer A, Felipó V. Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2h)-benzopyran (CR-6), an scavenger of nitric oxide.Biochem. Pharmacol. 58, 255-261 1999

García-Martínez, C., Humet, M.,  Planells-Cases, R., Sanchez-Baeza, F., Carbonell, T., Pérez-Payá, E., Belmonte, C., De Felipe, C.,  Messeguer, A. and Ferrer-Montiel, A.V. Attenuation of thermal nociception and inflammatory hyperalgesia by novel VR1 blocker.s Proc. Natl. Acad. Sci USA., 2002, 99, 2374-2379.

Montoliu, C., Humet, M., Canales, J.J., Burda, J., Planells-Cases, R., Sánchez-Baeza, F., Carbonell, T., Pérez-Paya, E., Messeguer, A., Ferrer-Montiel, A. and Felipo, V. Prevention of in vivo excitotoxicity by a family of trialkylglycines. A novel class of neuroprotectants. J. Pharmacol. Exp. Ther. 2002, 301, 29-36.

Planells-Cases, R., Montoliu, C., Humet, M., García-Martínez, C., Merino, J.M., Fernández, A.M., Pérez-Payá, E., Felipo, V., Messeguer, A. and Ferrer-Montiel, A. Identification and characterization of an alkylglycine-base NMDA receptor open channel blocker with in vitro and in vivo neuroprotectant activity. J. Pharmacol. Exp. Ther. 2002, 302, 163-173

Carbonell, T., Masip I., Sánchez-Baeza F., Delgado M., Araya, E., Llorens O., Corcho F., Pérez-Payá E., Pérez J.J., Messeguer A. Identification of Selective and Potent Inhibitors of Acetylcholinesterase from Combinatorial Libraries of 2,5-Piperazinediones. Molec. Div. 2002, 000.

Masip, I., Messeguer, A. La Química Combinatòria al llindar del segle XXI. Revista de la Societat Catalana de Química, 2002.

Monfort, P., Montoliu, C. Hermenegildo, C., Muñoz, M.D. and Felipo, V. Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors. (2000). Neurochem. Int. 37, 249-253.

Montoliu, C., Monfort, P., Carrasco, J., Palacios, O., Capdevila, M., Hidalgo, J., and  Felipo, V. Metallothionein-III Prevents Glutamate and Nitric Oxide Neurotoxicity in Primary Cultures of Cerebellar Neurons. (2000). J. Neurochem. 75:266-273.

Montoliu, C., Llansola, M., Monfort, P., Corbalan, R., Fernandez-Marticorena, I., Hernandez-Viadell, M.L. and Felipo, V. Role of Nitric Oxide and cyclic GMP in Glutamate-Induced Neuronal Death . (2001). Neurotoxicity Research. 3 (2): 179-188.

Kosenko, E., Kaminsky, Y, Stavroskaya, I.G. and Felipo, V. Alteration of mitochondrial calcium homeostasis by ammonia-induced activation of NMDA receptors in rat brain in vivo. (2000). Brain Res 880: 139-146.

Llansola, M., Sáez, R. and Felipo, V.  NMDA-induced phosphorylation of the microtubule-associated protein MAP-2 is mediated by activation of nitric oxide synthase and MAP-kinase. (2001). Eur J Neurosci 13: 1283-91.

Monfort, P., Corbalán, R., Martinez, L., López-Talavera, J.C., Córdoba, J. and Felipo, V.  Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis. (2001). Neuroscience 104: 1119-1125

Felipo, V. Glutamatergic Neurotransmission, Aluminium and Alzheimer's Disease. In: Aluminium and Alzheimer's Disease. The Science that describes the link. C. Exley, editor. Elsevier Science B. V. (2001). 323-344.

Corbalán, R., Miñana, MD, Del Olmo, JA, Serra, MA, Rodrigo JM and  Felipo, V.  Altered cGMP content and soluble guanylate cyclase in lymphocytes from patients with liver disease.  (2002). J. Mol Med  80, 117-123.

Montoliu, C., Humet, M., Canales, JJ., Burda, J., Planells-Cases, R., Sánchez-Baeza, F., Pérez-Payá, E., Messeguer, A., Ferrer-Montiel, A. and Felipo, V. A family of trialkylglycines with in vitro and in vivo neuroprotective activity against excitotoxicity. (2002). J. Pharmacol. Exp. Ther. 301, 29-36.

Dr  Pura Muñoz Cánoves

Irigoyen JP, Muñoz-Cánoves P, Montero L, Koziczak M, Nagamine Y. The plasminogen activator system: biology and regulation.Cell. Mol. Life Sci. 56:104-132, 1999.

Miralles F, Parra M, Caelles C, Nagamine Y, Félez J, Muñoz-Cánoves P. UV irradiation induces the murine urokinase-type plasminogen activator (uPA) gene via the c-Jun N-terminal kinase (JNK) signalling pathway. Requirement of an AP1 enhancer element Mol.Cell. Biol. 18:4537-4547, 1998.

Ferrer I, Puig B, Goutan E, Gombau L, Muñoz-Cánoves P.. "Methylazoximethanol acetate-induced cell death in the granule cell layer of the developing cerebellum is associated with caspase-3 activation, but does not depend on the tissue-type plasminogen activator". Neuroscience Lett. 299: 77-80, 2001

Tzarfaty-Majar  V+, López-Alemany R+, Feinstein Y, Gomabau L, Goldshmidt O, Soriano E, Muñoz-Cánoves P*, Klar A*..  "Plasmin-mediated release of the guidance molecule F-spondin from the extracellular matrix".J. Biol. Chem. 276: 28233-28241, 2001

Parra M, Lluís F, Miralles F, Caelles C, Muñoz-Cánoves P.. "The cJun N-terminal kinase (JNK) signaling pathway mediates induction of the proteolytic enzyme uPA by the alkylating agent MNNG . Blood 96:1415-1424, 2000.

M, Jard Mí, Magdalena Koziczak, Yoshikuni Nagamine, Pura Muñoz-Cánoves.. "p53 phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor- 1 (PAI-1) gene by the alkylating agent MNNG..J. Biol. Chem. 276: 36303-36310, 2001

Dr  Virginia Nunes Martínez

Dr  Jordi Casademont Pou

Miró O, Jarreta D, Casademont J, Barrientos A, Rodríguez B, Gómez M, Nunes V, Urbano-Márquez A, Cardellach F. Absence of mitochondrial dysfuncion in polymialgia rheumatica: evidence based on a simultaneous molecular and biochemical approach.Scandinavian Journal of Rheumatology 1999 28:1-5.

Gómez M, Miró O, Arias L, Barrientos A, Rojas I, Arruga J, Estivill X, Casademont J, Nunes V. Mitochondrial DNA LHON mutations in alcoholic patients developing amblyopia.Alcoholism (1999) 35:23-31.

Rodríguez-Santiago B, Casademont J, Nunes V.Is mitochondrial DNA depletion involved in Alzheimer's disease? European Journal of Human Genetics 9: 279-285 (2001)

Gómez-Zaera M, Strom T, Rodríguez B, Estivill X, Meitinger T, Nunes V. Presence of a major WFS1 mutation in Spanish wolfram Syndrome pedigrees. Molecular Genetics and Metabolism 72: 72-81 (2001).

Rodríguez-Santiago B, Casademont J, Nunes V. Quantification of mitochondrial DNA by real time Ligthcycler PCR in Alzheimer's disease.The American Journal of Human Genetics. Supplement 2 vol 67. Abstract 2014. pag. 360. (2000).

Rodríguez-Santiago B, Casademont J, Nunes V. Study of four mtDNA point mutations and mtDNA rearrangements in AD patients. HGM2001 Abstracts book. 249 pg.68.

Rodríguez-Santiago B, Casademont J, Nunes V. ¿Existe relación entre la enfermedad de Alzheimer y defectos en el DNA mitocondrial?. Revista de Neurología 33(4), 301-305 (2001).

Gómez-Zaera M, Strom T, Rodríguez B, Estivill X, Meitinger T, Nunes V Presence of a major WFS1 mutation in Spanish wolfram Syndrome pedigrees. Molecular Genetics and Metabolism 72: 72-81 (2001).

Miró O, Casademont J, Grau JM, Jarreta D, Urbano-Márquez A, Cardellach F. Histological and biochemical assessment of mitochondrial function in dermatomyositis. Br J Rheumatol 1998; 37:1047-1053

Miró O, Cardellach F, Casademont J. Polymyalgia rheumatica, ageing and mitochondria J Rheumatol 1999; 26:1636-1638

Miró O, Barrientos A, Alonso JR, Casademont J, Jarreta D, Urbano-Márquez A, Cardellach F. Effects of general anaesthetic procedures on mitochondrial function of human skeletal muscle. Eur J Clin Pharmacol 1999; 55:35-41

Miró O, Casademont J, Jarreta D, Grau JM, Urbano-Márquez A, Cardellach F. Skeletal muscle mitochondrial function in polymyalgia rheumatica associated giant cell arteritis. Rheumatology 1999; 38:568-571

Miró O, Alonso JR, Jarreta D, Casademont J, Urbano-Márquez A, Cardellach F. Smoking disturbs mitochondrial respiratory chain function and enhances lipid peroxidation on human circulating lymphocytes. Carcinogenesis 1999; 20:1331-1336

Miró O, Alonso JR, Casademont J, Jarreta D, Urbano-Márquez A, Cardellach F. Oxidative damage on lymphocyte membranes is increased in patients suffering from acute carbon monoxide poisoning. Toxicology Letters 1999; 110: 219-223

Gomez Zaera M, Miró O, Arias L, Barrientos A, Rojas I, Arruga J, Estivill X, Casademont J, Nunes V. Mitochondrial DNA LHON mutations in alcoholic patients developing amblyopia. Alcoholism 1999; 35: 23-33

Jarreta D, orús J, Barrientos A, Miró O, Roig E, Heras M, Moraes CT, Cardellach F, Casademont J. Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovasc Res 2000; 45: 860-865

Miró O, Robert J, Casademont J, Alonso JR, NIcolàs JM, Fernández-Solà J, Urbano-Márquez A, Hoek JB, Cardellach F. Heart mitochondrial respiratory chain complexes are functionally unaffecte in heavy ethanol drinkers without cardiomyopathy. Alcohol Clin Exp Res 2000; 24: 859-864

Miró O, Casademont J, Casals E, Perea M, Urbano-Márquez A, Rustin P, Cardellach F.Aging is associated with an increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. Cardiovasc Res 2000; 47:624-631                                  

Gómez-Zaera M, Miró O, Pedrol E, Soler A, Picón M, Cardellach F, Casademont J, Nunes V. Mitochondrial involvement in antiretroviral therapy-realted lipodystrophy. AIDS 2001; 15 15: 1643-1651

Wagner PD, Massanés F, Wagner H, Sala E, Miró O, Campistol JM, Marrades RM, Casademont J, Torregrosa V, Roca J. Muscle angiogenic grawth factor gene responses to exercice in chronic renal failure. Am J Physiol Reguratory Integrative Comp Physiol 2001; 281:R539-R546

Casademont J, Miró O. Electron transport chain defects in heart failure. Heart Failure Rev 2002; 7: 131-139

Miró, M. Laguno, J.R. Alonso, J. Casademont, C. Herrero, A. Selva, A. Urbano-Márquez y J.M. Grau.. Evolución de las miopatías inflamatorias idiopáticas: complicaciones, supervivencia y factores pronósticos. Med Clin (Barc) 1999; 112:521-526

Casademont J. Diabetes mitocondrial: ¿una diabetes distinta?. Med Clin (Barc) 1999; 112:96-98

Cardellach F, Casademont J. Enfermedades mitocondriales: un diagnóstico todavía difícil. Med Clin (Barc) 2000; 114:139-140

Casademont J, Jarreta D, Orús J, Miró O, Roig E, Heras M, Sanz G, Cardellach F. Mitochondrial electron transport chain enzymatic activities in idiopathic dilated cardiomyopathy. IX International Congress on Neuromuscular Diseases. Adelaide, August 1998. Muscle&Nerve 1998 (suppl.); 7:160

Masanés F, Miró O, Sala E, Casademont J, Marrades R, Campistol JM, Roca J, Urbano-Márquez A, Cardellach F. Uraemic myopathy: a morphometrical approach.. VI European Congress of Neuropathology. Barcelona, Mayo 1999. Neuropathol Appl Neurolbiol 1999; 25 (suppl.1):73-74

Miró O, Jarreta D, Robert J, Casademont J, Nicolás JM, Fernández-Solá J, Estruch R, Urbano-Márquez A, Cardellach F. Electron transoport chain (ETC) activity on heart mitochondria is unaffected in patients with chronic ethanol intake  without cardiomyopathy. 7th Congress of the European Society for Biomedical Research on Alcoholism. Barcelona, June 1999. Alcohol Alcoholism 1999; 34:467

Rodriguez Santiago B, Gómez Zaera M, Casademont J, Nunes V. Are A4336G point mutations and mtDNA rearrangements involved in Alzheimer's disease aethiology? 4th European Meeting on Mitochondrial Pathology. Cambridge, UK, September 1999

Rodríguez-Santiago B, Casademont J, Nunes V. Quantification of mitochondrial DNA by real time lightcycler PCR in Alzheimer's disease. Annual Meeting of the American Society of Hyman Genetics. Philadelphia, October 2000. Am J Human Genet 2000; 67(suppl 2): 360

Casademont J, Miró O, Viedma P, Blesa R, Cardellach F. Oxidation of mitochondrial respiratory chain complex i substrates is reduced in lymphocytes from Alzheimer's disease patients. II Joint Meeting of the Mitochondria Medicine Society and Mitochondria Research Society. San Diego, March 2001. Mitochondrion 2001; 1:101-102

Rodríguez-Santiago B, Casademont J, Nunes V. Quantification of mitochondrial DNA by real time Ligthcycler PCR in Alzheimer's disease. The American Journal of Human Genetics. Supplement 2 vol 67. Abstract 2014. pag. 360. (2000). 50 Congreso Americano de Genética

Rodríguez-Santiago B, Casademont J, Nunes V. Study of four mtDNA point mutations and mtDNA rearrangements in AD patients. HGM2001 Abstracts book. 249 pg.68. Comunicación al HUGO

Dr  Leonardo Pardo Carrasco

Bassols a, Bosch F, Campillo M, Cañellas M, Baños JE. An epidemiological comparison of pain complaints in the general population of Catalonia (Spain).Pain, 83,9-16 (1999)

Pardo L, Giraldo J. The slope parameter and the receptor reserve.Trends in Pharmacological Science 19, 445 (1998)

Pardo L, Sepulcre F, Caldera J, Duñach M, Labarta A, Tejada J, Padrós E. Experimental and theoretical characterization of the high affinity cation binding site of the purple membrane.Biophysical Journal, 75, 777-784 (1998)

Pardo L, Tabernero A, Giraldo J, Vila E. Modelling the changes due to the endothelium and hypertension in the alpha-adenoreceptor-mediated responses of rat aorta.Journal of Autonomic Pharmacology, 19, 219-228 (1999)

Pardo L, Giraldo J, Goñalons E, Vila E, Badia A. Andrenergic and purinergic components in bisected vas deferens from spontaneously hypertensive rats.British Journal of Pharmacology, 128, 873-880 (1999)

Pardo L, Giraldo J. A pH-Dependent Model of the Activation Mechanism of the Histamine H2-Receptor.Biochemical Pharmacology, 58, 343-353 (1999)

A. Morón, M. Campillo, V. Perez, M. Unzeta, L. Pardo..Molecular Determinants of MAO Selectivity in a Series of Indolealkylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis and Computational Simulation of Ligand Recognition. Journal of Medicinal Chemistry, 43, 1684-1691 (2000)

J.A. Ballesteros, X. Deupi, M. Olivella, E.E.J. Haaksma, L. Pardo. Serine and Threonine Residues Bend a-Helices in the c1=g- conformation Biophysical Journal, 79, 2754-2760 (2000)

M.L. Lopez-Rodriguez, M.J. Morcillo, E. Fernández, M.L. Rosado, L. Pardo, K.-J. Schaper Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT1A Affinity/Selectivity by Classical Hansch Analysis, Artificial Neural Network, and Computational Simulation of Ligand Recognition Journal of Medicinal Chemistry, 44, 198-207 (2001a)

C. Govaerts, C. Blanpain, X. Deupi, S. Ballet, J.A. Ballesteros, S. Wodak, G. Vassart, L. Pardo, M. Parmentier The TxP motif in the second transmembrane helix of CCR5: a structural determinant in chemokine-induced activation Journal of Biological Chemistry, 276, 13217-13225 (2001a)

C. Govaerts, A. Lefort, S. Costagliola, S. Wodak, J.A. Ballesteros, L. Pardo, G. Vassart A conserved Asn in transmembrane helix 7 is an on/off switch in   the activation of the Thyrotropin receptor. Journal of Biological Chemistry, 276, 22991-22999 (2001b)

M.L. Lopez-Rodriguez, B. Benhamu, A. Viso, M. Murcia, L. Pardo. Study of the bioactive conformation of novel 5-HT4 receptor ligands: influence of an intramolecular hydrogen bond .Tetrahedron, 57, 6745-6749 (2001b)

M.L. Lopez-Rodriguez, M. Murcia, B. Benhamu, A. Viso, M. Campillo, L. Pardo .3D-QSAR/CoMFA and Recognition Models of Benzimidazole Derivatives at the 5-HT4 Receptor. Bioorganic Medicinal Chemistry Letters, 11, 2807-2811 (2001c)

M.L. Lopez-Rodriguez, M. Murcia, B. Benhamu, M. Olivella, M. Campillo, L. Pardo. Computational Model of the Complex between GR113808 and the 5-HT4 Receptor Guided by Site-Directed Mutagenesis and the Crystal Structure of Rhodopsin. Journal of Computer-Aided Molecular Design, 15, 1025-1033 (2001d)

S. Claeysen, C. Govaerts, A. Lefort, J. Van Sande, S. Costagliola, L. Pardo, G. Vassart- A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist. FEBS Letters, 517, 195-200 (2002)

M.L. Lopez-Rodriguez, B. Benhamu, M.J. Morcillo, M. Murcia, A. Viso, M. Campillo, L. Pardo- 5-HT4 Receptor Antagonists. Structure-Affinity Relationships and Ligand-Receptor Interactions. Current Topics in Medicinal Chemistry, 2, 625-641 (2002a)

M. Olivella, X. Deupi, C. Govaerts, L. Pardo -.Influence of the environment in the conformation of a-helices studied by protein database search and molecular dynamics simulations. Biophysical Journal, 82, 3207-3213 (2002)

M.L. López-Rodríguez, B. Vicente, X. Deupi, S. Barrondo, M. Olivella, M.J. Morcillo, B. Behamu,  J.A. Ballesteros, J. Sallés, L. Pardo. Design, synthesis and pharmacological evaluation of 5-HT1A receptor ligands to explore the three-dimensional structure of the receptor. Molecular Pharmacology, 62, 15-21 (2002b)

Dr  Jesús Pérez i Clausell

Franco-Pons N, Casanovas-Aguilar C, Arroyo S, Rumià J, Pérez-Clausell J, Danscher G. Zinc-rich synaptic boutons in human temporal cortex biopsies.Neuroscience 98, 429-435. 2000

Casanovas-Aguilar C, Reblet C, Pérez-Clausell J, Bueno-López JL. Zinc-rich afferents to the rat neocortex: projections to the visual cortex traced with intracerebral selenite injections.J. Chem. Neuroanat. 15, 97-109. 1998

Mengual E, Casanovas-Aguilar C, Pérez-Clausell J , Giménez-, Amaya JM Thalamic distribution of zinc-rich terminal fields and neurons of origin in the rat . Neuroscience102, 865-886. 2001

Casanovas-Aguilar C, Miró-Bernié N, Pérez-Clausell J. Zinc-rich neurones in the rat visual cortex give rise to two laminar segregated systems of connections. Neuroscience 110, 445-458. 2002.

Valente T, Auladell C, Pérez-Clausell J. Postnatal development of zinc-rich terminal fields in the brain of the rat. Experimental Neurology, 174, 215-229. 2002.

Dr  Alberto Prats Galino

Puigdellívol-Sánchez S, Prats-Galino A, Ruano-Gil D, Molander CJ. Fast Blue and Diamidino Yellow as retrograde tracers in peripheral nerves: efficacy of combine nerve injection and capsule application to transected nerves in the adult rat.Neuroscience Methods. 95 (2000):103-110

Puigdellívol-Sánchez S, Prats-Galino A, Ruano-Gil D, Molander CJ. Efficacy of the fluorescent dyes fast blue, fluoro-gold, and diamidino yellow for retrograde tracing to dorsal root ganglia after subcutaneous injection.Neuroscience Methods 86 (1998): 7-16

Puigdellívol-Sánchez S, Prats-Galino A, Ruano-Gil D, Molander CJ. Sciatic and femoral sensory neurones occupy different regions within L4 dorsal root ganglion in the adult rat.Neuroscience Letters 251 (1998): 169-172

Puigdellívol-Sánchez S, Prats-Galino A, Ruano-Gil D, Molander CJ. The representations of hindlimb digits in rat dordal root ganglia.Comp. Neurol. 408 (1999):137-45 i portada.

Puigdellívol-Sánchez A., Forcada-Calvet P., Prats-Galino A., Molander C. "The relative contribution of femoral and sciatic nerve branches to the sensory innervation of the hindlimb digits in the rat". Anat. Rec. 260:180-188 (2000) . 

Puigdellívol-Sánchez A., Valero Cabré A., Prats-Galino A., Navarro X., Molander C. "On the use of fast blue, fluoro-gold and diamidino yellow for retrograde tracing after peripheral nerve injury: uptake, fading, dye interactions and toxicity", J. Neurosci. Methods 115:115-127 (2002).

Puigdellívol-Sánchez A., Forcada-Calvet P., Prats-Galino A. Molander, C. Contribution of femoral and proximal sciatic nerve branches to the sensory innervation fhindlimb digits in the rat. The Anatomical Record. (in press)

Dr Margarita M. Puig Riera de Conías

Dr Eulalia Planas Domingo

Valle Ll, Puig MM, Pol O. Effects of mu-opioid agonists on intestinal secretion and permeability during acute intestinal inflammation in mice.Eur J Pharmacol 389:235-242, 2000

Planas MM, Sánchez S, Rodríguez L, Pol O, Puig MM. Antinociceptive / antiinflammatory effects of free and liposomal morphine in a rat model of carrageenan induced arthritis. Pharmacology 60:121-127, 2000.

Puig MM, Valle Ll, Pol O. Peripheral inflammation enhances the inhibitory effects of mu and delta oipids in the gut. Eur J Anaesth, supp 19, pp 127, 2000

Puigdellívol-Sánchez A, Prats-Galino A, Ruano-Gil D, Molander CJ. Fast Blue and Diamidino Yellow as retrograde tracers in peripheral nerves: efficacy of combine nerve injection and capsule application to transected nerves in the adult rat.Neuroscience Methods. 95 (2000): 103-110

Puigdellívol-Sánchez A, Prats-Galino A, Ruano-Gil D, Molander CJ. Efficacy of the fluorescent dyes fast blue, fluoro-gold, and diamidino yellow for retrograde tracing to dorsal root ganglia after subcutaneous injection.Neuroscience Methods. 86 (1998): 7-16

Puigdellívol-Sánchez A, Prats-Galino A, Ruano-Gil D, Molander CJ. Sciatic and femoral sensory neurones occupy different regions within L4 dorsal root ganglion in the adult rat.Neuroscience Letters 251 (1998): 169-172.

Puigdellívol-Sánchez A, Prats-Galino A, Ruano-Gil D, Molander CJ. The representations of hindlimb digits in rat dorsal root ganglia.Comp. Neurol. 408(1999):137-45 i portada.

Puig, MM; Pol, O. effects of opioids in a model of chronic intestinal inflammation in mice Peripheral. Journal of Pharmacology and Experimental Therapeutics 1998, 287:1068-1075.

Planas, ME; Puig, MM; Sánchez, S. Eds. Atlas del farmacológico del dolor. Publicaciones Menarini Barcelona, pp 1-60, 1998. (Llibre)

Pol, O; Valle, Ll; Sánchez-Blázquez, P; Garzón, J; Puig, MM. Antibodies and antisense oligodeoxynucleotides to m-opioid receptors, selectively block the effects of m-opioid agonists on intestinal transit and permeability in mice. British Journal of Pharmacology 1999, 127:397-404.

Puig MM, Warner W, Pol O. Intestinal inflammation and morphine tolerance alter the interaction between morphine and clonidine on gastrointestinal transit in mice. Anesthesiology, 93:219-230, 2000.

Puig MM, Barrera E. Tratramiento del dolor agudo. Temas de Actualización del Curso de Formación Continuada, Hospital del Mar. Edita Dr. L Drobnic pp 47-55, 2000. (Capítol de llibre)

Valle L, Pol O, Puig MM. Intestinal inflammation enhances the inhibitory effects of opioids on intestinal permeability in mice. .Journal of Pharmacology and Experimental Therapeutics 296: 378-387, 2001

Puig MM, Barrera E, Pol O. Mecanismo/s de acción de los opioides. In "Opioides: Utilización Clínica", Eds L Aliaga, E. Catalá. You & Us SA, Madrid, pp 1-7, 2001 (Capítol de llibre)

Pol O, Valle Ll, Puig MM .Antisense oligodeoxynucleotides to m -opioid receptor mRNA block the enhanced effects of opioids during intestinal inflamation. European Journal of Pharmacology 428: 127-136, 2001.

Pol O, Alameda F, Puig MM. Inflammation enhances m -opioid receptor transcription and expression in mice intestine. Molecular Pharmacology; 60:894-899, 2001.

Planas ME, Puig MM, Sánchez S. Eds. Tratamiento Farmacológico del Dolor en Odontoestomatología. Publicaciones Menarini Barcelona, pp 1-144, 2001.

Barrera E, Puig MM. Nuevas vías de administración del fentanil transdérmico y oral. Indicaciones en analgesia. Edita Dr. L Drobnic pp 383-389, 2001. (Capítol de llibre)

Planas, ME; Puig, MM; Sánchez, S. Eds. Atlas del farmacológico del dolor. Publicaciones Menarini Barcelona, pp 1-60, 1998. (Llibre)

Planas ME, Puig MM, Sánchez S Eds. Tratamiento Farmacológico del Dolor en Odontoestomatología. Publicaciones Menarini Barcelona, pp 1-144, 2001.

Puig MM, Pol O, Sánchez S, Rodríguez L, Planas ME Antinociceptive/anti-oedema effects of free and liposomal morphine in a rat model of carrageenan-induced arthritis. 6th European Society ofAnaesthesiologists. Brit J Anaesth 80: Supp 1, p 125, 1998.Barcelona, Espanya

Valle; Ll; Pol, O; Puig, MM Effects of morphine on intestinal permeability in mice with inflammatory diarrhoea. Forum European Neuroscience. European Journal of Neuroscience, 10 (Suppl.10), p.439, 1998 Berlin, Germany

Pol, O; Valle, Ll; Sánchez-Blázquez,P; Garzón, J; Puig, MM Antibodies and antisense oligodeoxinuleotides to m-opioid receptors, selectively block the effects of m-opioid agonists on intestinal transit and permeabilty in mice. 2ond European Opioid Conference; Dolor, 14 (Suppl. 1), p. 53, 1999 Barcelona, Espanya

Valle, Ll; Pol, O; Puig, MM Inflammation of the gut enhances the inhibitory effects of d opioid agonist on intestinal permeability in mice.2ond European Opioid Conference, Dolor, 14 (Suppl. 1), p. 54, 1999 Barcelona, Espanya

Valle, Ll; Pol, O; Puig, MM Efectos inhibitorios de los opiáceos sobre la permeabilidad intestinal durante la inflamación crónica en ratón.VII Reunión del Grupo Español de Motilidad Digestiva, Progr and Abstracts, p.5, 1999 Barcelona, Espanya

Romero, A; Planas, ME; Pol, O; Sánchez, S; Puig, MM Effects of m and k opioid agonists on plasma extravasation and edema induced by carrageenan in the rat paw. 9th World Congress on Pain. IASP Publications. Congress Abstracts, p.18, 1999 Viena, Austria

Poveda R, Planas E, Sámchez S, Pol O, Puig MM Interacción metamizol-tramadol en un modelo de dolor visceral en rata.IV Congreso de la Sociedad Española del Dolor. Revista de la Sociedad Española del Dolor, 6 (Suppl. II), p. 16, 1999. Málaga, Espanya

Pol O, Puig MM Peripheral inflammation increases the expression of mRNA that codifies for the m-opioid receptors in mice intestine. 29th Annual Meeting Society for Neuroscience, Soc Neurosci Abstr 25, Part 1, p. 1035, 1999 Miami, USA

Puig MM, Valle Ll, Pol O Peripheral inflamation enhances the inhibitory effects of mu and delta opioids in the gut. European Society of Anaesthesiologists. Eur J Anaesth, supp 19, pp.127, 2000 Viena, Austria

Romero A, Planas E, Sánchez S, Pol O, Puig MM Anti-Inflamatory effects of Opioid Agonists in a model of carrageenan-induced Mono Arthritis in the rat. 8th Europain Conference on Pain. Dolor 15 (suppl. III) pp. 26, 2000 Roma, Italy

Poveda R, Planas E, Sánchez S, Pol O, Puig MM Evaluation of the metamizol-tramadol interaction in a rat model of acute visceral pain. EuroPain 8th European Conference on Pain. Dolor 15 (Suppl. III) p. 26, 2000. Roma, Italia

Pol O, Alameda F, Puig MM Peripheral inflamation enhances m-opioid receptor inmunoreactivity in mice intestine. 30th Ann Meeting of the Soc Neurosc. Book of Abstracts Vol 26, pp. 2098, 2000 New Orleans, USA,

Romero A, Planas E, Poveda R, Sánchez S, Puig MM Efecto de la Capsaicina sobre la respuesta antiinflamatoria de los agonistas opioides m. Congreso sobre Mecanismos y Tratamiento del Dolor. Dolor 16, (Suppl II), pp. 61, 2001 Barcelona, Espanya

Jiménez-León N, Pol O, Puig MM Extravasación de plasma durante la inflamación intestinal: efecto de los agonistas opioides d, k Congreso sobre Mecanimos y Tratamiento del Dolor. Dolor 16, (Suppl II.), p. 62, 2001 Barcelona, Espanya

Pol O, Martín-Campos JM, Valle Ll, Jiménez-León N, Puig MM L'Expressió dels receptors opioids m i d augmenta durant la inflamació intestinal en ratolí. Seccions de Biologia Molecular i Biologia del Desenvolupament. Llibre d'abstracts, p.17, 2001 Canet de Mar, Espanya

Pol O, Martín-Campos JM, Valle Ll, Jiménez-León N, Puig MM d-opioid gene transcription is enhanced during intestinal inflammation in mice. 31st Ann Meeting of the Soc Neurosc. Book of Abstracts, 37.11, 2001 San Diego, USA

Puig MM, Pol O, Sánchez S, Rodríguez L, Planas ME. Antinociceptive/anti-oedema effects of free and liposomal morphine in a rat model of carrageenan-induced arthritis. 6th European Society ofAnaesthesiologists. Brit J Anaesth 80: Supp 1, p 125, 1998. Barcelona, Espanya

Romero, A; Planas, ME; Pol, O; Sánchez, S; Puig, MM Effects of m and k opioid agonists on plasma extravasation and edema induced by carrageenan in the rat paw. 9th World Congress on Pain. IASP Publications. Congress Abstracts, p.18, 1999 Viena, Austria

Poveda R, Planas E, Sámchez S, Pol O, Puig MM Interacción metamizol-tramadol en un modelo de dolor visceral en rata. IV Congreso de la Sociedad Española del Dolor. Revista de la Sociedad Española del Dolor, 6 (Suppl. II), p. 16, 1999. Málaga, Espanya

Romero A, Planas E, Sánchez S, Pol O, Puig MM Anti-Inflamatory effects of Opioid Agonists in a model of carrageenan-induced Mono Arthritis in the rat. 8th Europain Conference on Pain. Dolor 15 (suppl. III) pp. 26, 2000 Roma, Italia

Poveda R, Planas E, Sánchez S, Pol O, Puig MM Evaluation of the metamizol-tramadol interaction in a rat model of acute visceral pain. EuroPain 8th European Conference on Pain. Dolor 15 (Suppl. III) p. 26, 2000. Roma, Italia

Romero A, Planas E, Poveda R, Sánchez S, Puig MM Efecto de la Capsaicina sobre la respuesta antiinflamatoria de los agonistas opioides m. Congreso sobre Mecanismos y Tratamiento del Dolor. Dolor 16, (Suppl II), pp. 61, 2001 Barcelona, Espanya

Dr  Ricardo Pujol Borrell

R  Brunoa, L Sabatera, E Tolosa, M Sospedraa, X Ferrer-Francesch, J Coll, M Foz, A Melms, R Pujol-Borrell. Different pattems of nicotinic acetylcholine receptor subunit transcription in human thymus. Journal of Neuroimmunology 149 (2004) 147-159

Dr  Joan Sahuquillo i Barris

De Nadal M, Munar F, Poca MA, Sahuquillo J, Garnacho A. Cerebral hemodynamic effects of morphine and fentanyl in patienth with sever head injury. Adsence of correlation to cerebral autoregulation.Anesthesiology 2000; 92:11-9

Sahuquillo J, Poca MA.  Diffuse axonal injury after head trauma.  A review.  In: J. Pickard. Advances and Technical Standards in Neurosurgery. Wien:Springer-Verlag;  2002.  (27). p  24-86.

De Nadal M, Sahuquillo J.  Opiates, intracranial pressure, and autoregulation (Reply letter). Anestesiology 2001: 94:177-8

Poca MA, Mataró M, Sahuquillo J.  Actualizaciones sobre la fisiopatología, diagnóstico, tratamiento y valoración de secuelas en los traumatismos craneoencefálicos.  En: Miralles RC.  Valoración del daño corporal en el aparato locomotor.  1ª ed.  Barcelona: Masson, S.A.; 2001.  p. 303-13.

Sahuquillo J, Amorós S, Santos A, Poca MA, Valenzuela H, Báguena M, Garnacho A.  False autoregulation (Pseudoautoregulation) in patients whith severe head injury.  Its importance in CPP management.  Acta Neurochir (Suppl) 2000: 76:485-490.

Sahuquillo J, Amorós S, Santos A, Poca MA, Panzardo H, Domínguez L, Pedraza S.  Does an increase in cerebral perfusion pressure always mean a better oxygenated brain?  A study in head-injured patients.  Acta Neurochir (Suppl) 2000:76:457-462.

Sahuquillo J, Poca MA, Amorós S.  Current Aspects of Pathophysiology and Cell Dysfunction after Severe Head Injury.  In: Current Pharmaceutical Design 2001. 7(15).  p 1475-1503.

Sahuquillo J.  Evidenced-based medicine and clinical practice guidelines for traumatic brain  injury.  In: Gonzalez-Feria L, von Wild KRH, Dimath HE,  eds. Quality Management in Head Injuries Care. Critical approaches to health economics, patient selection and acute treatment. La Laguna, Spain: El Productor SL; 2000.  p 109-17

Dr  Lluís San Molina

Arranz B, Dueñas RM, Sarro S. El hombre que no decía nada.Benito Menni, Complejo Asistencial en Salud Mental.Barcelona Casos Clinicos de Residentes en Psiquiatría 2. (c) Copyright, 1999. Smithkline Beecham. pp 35-38

Rosel P, Arranz B, San L, Urretavizcaya M, Marcusson J, Navarro MA. 5-HT2A receptors and their second mesenger IP3 are only correlated in human brain and not in platelets. Neurosci Res Comm 25(3): 129-137 (1999).

Rosel P., Arranz B.; Urretavizcaya M. Oros M., San L., Vallejo J., Navarro M.A. Different distributions of the 5-HT reuptake complex and the postsynaptic 5-HT 2A receptors in Brodmann afeas and brain hemispheres. Psychiatry Research 111 (2002) 105-115

Dr  Eduardo Soriano García

Dr  Myriam Fabre

Aguiló A, Schwartz TH, Kumar V, Peterlin Z, Tsiola A, Soriano E, Yuste R. Involvement of Cajal-Retzius neurons in spontaneous correlated activity of embryonic and postnatal layer I from wild-type and reeler mice.The Journal of Neuroscience, (1999), 19: 10856-10868.

Martínez A, Alcántara S, Borrel V, Del Río JA, Blasi J, Otal R, Campos N, Boronat A, Barbacid M, Silos-Santiago I, Soriano E. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections.Journal of Neuroscience 18:7336-7350. 1998

Pascual M, Acsády L, Rocamora N, Freund TF, Soriano E. Expression of Neurotrophins in hippocampal interneuronsimmunoreactives for the neuropeptides somatestatine, neuropeptide-Y, vasoactive intestinal, polypeptide and cholecystokinin.Journal of Neuroscience 89:1089-1101. 1999

Borrell V, Del Río JA, Alcántara S, Derer M, Martínez A, DArcangelo G, Nakajima K, Mikobisha K, Derer P, Curran T, Soriano E. Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections Journal of Neuroscience 19:1345-1358. 1999

Chédotal A, Del Río JA, Ruíz M, Borrel V, De Castro F, Ezan F, Goodman CS, Tessier-Lavigne M, Sotelo C, Soriano E. Semaphorins III and IV repel hippocampal axons via two distinct receptors.Development 125:4313-4323. 1998

Álvarez-Dolado M, Ruíz M, Del Río JA, Alcántara S, Burgaya F, Sheldon M, Nakajima N, Bernal J, Howell B, Curran T, Soriano E, Muñoz A. Thyroid hormone regulates reelin and dab1 expression during brain development.Journal of Neuroscience 19: 6979-6993. 1999

Pucharcós C, Fuentes JJ, De la Luna S, Alcántara S, Arbonés M, Soriano E, Estivill X, Pritchard M. Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome.European Journal of Human Molecular Genetics, (1999), 7: 704-712.

Alcántara S, Ruíz M, De Castro F, Soriano E, Sotelo C. Netrin-1 acts as an atractive or as a repulsive cue for distinc migrating neurons during the development of the cerebellar system.Development, (2000) 127: 1359-1372.

Borrell V, Ruíz M, Del Río JA, Soriano E. Development of commisural connections in the hippocampus of reeler mice: evidence of an inhibitory influence of Cajal-Retzius cells.Experimental Neurology 156:268-282. 1999

Barallobre, M.J., Del Río, J.A., Alcántara, S., Borrel, V., Ruíz, M., Fabre M., Martín M., Tessier-Lavigne, M.and E. Soriano. Aberrant development of hippocampal circuits in netrin 1-deficient mice (2000) Development,127: 1359-1372.    

García-Frigola, C., Burgaya, F., Calbet, M., de Lecea, L. and Soriano, E. Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures. Neuroreport (2000), 11(14):3181-3185.   

Casas, C., Martínez, S., Pritchard, M.A., Fuentes, J.J., Nadal, M., Guimerà, J., Arbonés, M., Flórez, J., Soriano, E., Estivill, X., Alcántara, S. Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressedin the primitive ventricle of the heart and during neurogenesis. Mechanisms of Development, (2001), 101(1-2):289-292.     

Pozas, E., Pascual, M., Guijarro, P., Kim Nguyou, Sotelo, C., Chedotal, A., Del Río, J.A. and Soriano, E. Age dependent effects of secreted semaphorins 3A, 3F and 3E on developing hippocampal axons. Molecular and Cellular Neuroscience, (2001), 18: 26-43.    

Burgaya, F., Alcantára, S., Ruiz, M., Fabre, M., Real, F.X., Tessier-Lavigne, M., y Soriano, E. Expression de Netrina-1 y su receptor DCC durante el desarrollo del telencefalo de ratón. Neurologia, 25, 1725 (1997)    

Fabre, M., Martín, M., Ulloa, F. & Real, F.X. In vitro analysis of the role of DCC in mucus-secreting intestinal differentiation. Int. J. Cancer, 81, 799-807 (1999).   

Barallobre, M.J., Del Río, J.A., Alcántara, S., Borell, V., Ruiz, M., Fabre, M., Martín, M., Tessier-Lavigne, M., and Soriano, E. Aberrant development of hippocampal circuits in netrin-1 deficient mice. Development, 127:4797-4810 (2000).   

Pascual, M., Pozas, E. and Soriano E. The Septohippocampal pathway: Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway. Journal of Neuroscience, (2000), (submitted)

García-Frigola, C., Burgaya, F., Calbet, M., de Lecea, L. and Soriano, E. A collection of cDNAs enriched in upper cortical layers of the mouse embryo. Cerebral - Cortex, (2001), (submitted)

Del Río, J.A.; Salé, M., Borrell, V., Martínez, A. and Soriano E. Regeneration ofadult entorhino-hippocampal axon by immediate and delayed transplantation of perinatal target tissue. Nature Medicine (2000), (in preparation)

Dr  Eduard Tolosa Sarró

Pérez-Navarro E, Alberch J, Neveu I, Arenas E. Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes of striatal projection neurons after excitotoxicity in vivo.Neuroscience 91 (4), 1257-1264, 1999

Canals JM, Checa N, Marco S, Michels A, Pérez-Navarro E, Alberch J. The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum.Molecular Brain Research, 69 (2), 242-248, 1999

Canals JM, Marco S, Checa N, Michels A, Pérez-Navarro E, Arenas E, Alberch J. Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotocicity in a rat model of Huntingtons disease.Neurobiology of Disease, 5, 357-364, 1998

Reiriz J, Espejo M, Ventura F, Ambrosio S, Alberch J. Bone morphogenetic protein-2 promotes dissociated survival and differentiation effects in cultured ventral mesencephalic dopaminergic neurons.Journal of Nuerobiology 38, 161-170, 1999

Perez-Navarro E., P. Akerud, S. Marco, J.M. Canals , E. Tolosa, E. Arenas.  J. Alberch. Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease.: Neuroscience 98, 89-96, 2000

Perez-Navarro E., A.M. Canudas, P. Akerud, J. Alberch, E. Arenas. BDNF, NT-3 and NT-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease. Journal of Neurochemestry 75, 2190-2199, 2000

Checa N, J.M. Canals, J. Alberch.Developmental regulation of BDNF andNT-3 expression by quinolinic acid in the striatum and its main connectionsNeurology, 165, 118-124, 2000

Canals, J.M., N. Checa, S. Marco. Akerud, A. Michels, E. Perez-Navarro, E..Tolosa, E. Arenas. and J. Alberch.Expression of BDNF in cortical neurons isregulated by striatal target area.Journal of Neurosciencie 21, 117-124,2001

Gratacos, E., N. Checa, and J. Alberch.Bone morphogenetic protein-2, butnot bone morphogenetic protein-7, promotes dendritic growth and calbindinphenotype in cultured striatal neurons: Neurosciencie 104, 783-790, 2001

Gratacos, E., E. Perez-Navarro, E. Tolosa, E. Arenas. and J. Alberch.Neuroprotection of striatal neurons against kainate excitotoxicity byneurotrophins and GDNF family members..Journals of Neurochemistry 78,1287-1296, 2001

Checa, J.M. Canasls E. Gratacos, and J. Alberch.TrkB and TrkC aredifferentially regulated by excitotoxicity during development of the basalganglia..Experimental Neurology, 172, 282-292, 2001

Gratacos, E., N. Checa,., E. Perez-Navarro, and J. Alberch. Brain-derivedneurotrophic factor mediates bone morphogenetic protein-2 effects on culturedstriatal neurons., Journals of Neurochemistry 79, 747-755, 2001

Marco S, E. Perez-Navarro, E. Tolosa, E. Arenas and J. Alberch.Striatopallidal neurons are selectively protected by neurturin in anexcitotoxic model of Huntington's disease.: Journal of Neurobiology, 50,291-304, 2002

Marco S., A. Canudas, J.M. Canals, N. Gavalda, E. Perez-Navarro and J.Alberch.Excitatory amino acids differentially regulate the expression ofGDNF, neurturin and their receptors in the adult rat striatum.: ExperimentalNeurology 174,243-252, 2002

Dr  Josep M. Tusell Puigbert

Solà C, Tusell JM, Serratosa J. Comparative study of the distribution of calmodilin kinase II and calcineurin in the mouse brain.Journal of Neurosciences Research, 57: 651-662 (1999).

Solà C, Tusell JM, Serratosa J. Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures.Journal of Neurochemistry, 70: 1600-1608 (1998).

Solà C, Tusell JM, Serratosa J. The calcium/calmudulin signaling system in the neural response to excitability. Involvement of neronal and glial cells. Involvement of neronal and glial cells.Progress in Neurobiology, 58: 207-232 (1999).

Casal C, Tusell JM, Serratosa J. Role of calmodulin in the differentiation/activation of microglial cells. Brain Research, 902;101-107 (2001).

Solà C,Tusell JM, Serratosa J. The calcium/calmodulin system in neuronal hyperexcitability.The International Journal of Biochemistry & Cell Biology 33;439- 455 (2001).

C. Casal, J. Serratosa and J.M. Tusell. Relation between â -AP peptides aggregation and microglial activation Brain Research,928: 76-84 (2002).

S. Barrón, J.M. Tusell and J. Serratosa. Age-related expression of presenilin 1 in mice. Journal of Neurochem. (sent)

C. Sola, J. M. Tusell and J. Serratosa. Astroglia potentiates the nitric oxide production by microglia.(in preparation).

F.Rabanal ., M.R. Sastre, M.R. Quintero, J.M. Tusell ,Serratosa J., F. Albericio and E. Giralt. A study on the aggregational and toxicological properties of the 12-28 peptide fragment corresponding Alzheimer's beta amyloid protein. (in preparation).

Dr  Eduard Vieta Pascual

Vieta E, Martínez-Arán A, Colom F, Reinares M, Benabarre A, Corbella B, Barrantes M, Gastó C. Efectividad del tratamiento de la depresión bipolar con venlafaxina y estabilización del estado de ánimo.Psiquiatria Biológica. Volumen 6, núm. 2, marzo-abril 2000

Martínez-Arán A, Vieta E, Colom F, Reinares M, Benabarre A, Gastó C, Salamero M. Cognitive Dysfunctions in Bipolar Disorder: Evidence of Neuropsychological Disturbances.Psychother Psychosom 2000; 69:2-18

Colom F, Vieta E, Corbella B, Martínez-Arán A, Reinares M, Benabarre A, Gastó C . Clinical factors associated to treatment non-compliance in euthymic bipolar patients . J Clin Psychiatry 2000; 61: 549-555.

Vieta E, Martínez-Arán A, Nieto E, Colom F, Reinares M, Benabarre A, Gastó C. Adjunctive gabapentin treatment of bipolar disorder. Eur Psychiatry 2000, 15: 433-437.

Benabarre A, Vieta E, Lomeña F, Martínez-Arán A, Bernardo M, Corbella B, Colom F, Reinares M, Gastó C. La neuroimagen funcional de las emociones y el trastorno bipolar. Actas Esp Psiquiatr 2000; 28: 257-261.

Reinares M, Martínez-Arán A, Colom F, Benabarre A, Salamero M, Vieta E. Efectos a largo plazo del tratamiento con risperidona versus neurolépticos convencionales en el rendimiento neuropsicológico de pacientes bipolares eutímicos . Actas Esp Psiquiatr 2000; 28: 231-238.

Colom F, Vieta E, Benabarre A, Martínez-Arán A, Reinares M, Corbella B, Gastó C. Topiramate abuse in a bipolar patient with an eating disorder. J Clin Psychiatry 2001; 62: 475-476.

Vieta E, Colom F, Martínez-Arán A, Reinares M, Benabarre A, Corbella B, Gastó C. Reboxetine-induced hypomania. J Clin Psychiatry 2001; 62: 655-656.

Vieta E, Colom F, Martínez-Arán A, Benabarre A, Reinares M, Gastó C. Bipolar II disorder and comorbidity. Comp Psychiatry 2000;  41:1-6.

Vieta E, Martínez-Arán A, Colom F, Renares M, Benabarre A, Corbella B, Barrantes N, Gastó C. Efectividad del tratamiento de la depresión bipolar con venlafaxina y estabilizadores del estado de ánimo. Psiquiatría Biológica 2000; 7:65-69.

Vieta E, Martínez de Osaba MJ, Colom F, Martínez-Arán A, Benabarre A, Gastó C. Aumento de la respuesta de ACTH a la administración de CRF como predictor de manía en pacientes bipolares eutímicos. Rev  Psiq Fac Med Barna 2000; 27:393-400.

Vieta E, Corbella B, Reinares M, Benabarre A, Gilaberte I, Colom F, Martínez-Arán A, Gastó C, Tohen M. Olanzapine as long-term adjunctive therapy in treatment-resistant bipolar disorder. J Clin Psychopharmacol, 2001; 21: 469-473

Colom F, Sarrantes N, Martínez-Arán A, Reinares M, Benabarre A, Vieta E. A cognitive model for hypomania: the path between neurobiology and behavior. Psychiatrv Networks,en premsa.

Vieta E, Senabarre A, Colo m F, Corbella B, Reinares M, Martínez-Arán A, Gastó C. Uso y manejo de la risperidona en el tratamiento de los trastornos bipolares. Actas Españolas de Psiquiatría, (in press).

F Colom, PhD; E Vieta, A Martínez-Arán, M Reinares; J M Goikolea; A Benabarre, C Torrent; M Comes; B Corbella; G Parramon; J Corominas. Randomized Trial on the Efficacy of Group Psychoeducation in the Prophylaxis of Recurrences in Bipolar Patients Whose Disease Is in Remission. Arch Gen Psychiatry/60 402-407 2003