CÀNCER. 1994. PROJECTES FINANÇATS

Dr  Montserrat Andreu García

Andreu M. Registre de càncer hereditario Gastroenterol.Hepatol. 1999; 22:429-432 Articulo especial.

Andreu M, Bahia D, Barretto Cicarelli RM, Codony C, Khaouja A, Aviñó AM, Eritja R, Bach-Elias M. Preparation of N2,N2-7-trimetilguanosine affinity columns Nucleosides & Nucleotides Vol. 18 (1) p. 125-136. 1999

Dr  Montserrat Bach Elias

Espuny R, Bahia D, Barretto Cicarelli RM, Codony C, Khaouja A, Aviñó AM, Eritja R, Bach-Elias M. Preparation of N2,N2-7-trimetilguanosine affinity columns.Nucleosides & Nucleotides Vol. 18 (1) p.125-136. 1999

Dr  Oriol Bachs Valldeneu

Tarafa G, Villanueva A, Farré L, Rodríguez J, Musulén E, Puig P, Reyes G, Olmedo E, Paules AB, Peinado MA, Bachs O, Capellà G. DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination.Oncogene, 19, 546-555, 2000.

Agell M, Aligué R, Alemany V, Castro A, Jaime M, Pujol MJ, Rius E, Serratosa J, Taulés M, Bachs O. New nuclear functions of calmodulin.Cell calcium, 23,115-121.

Villanueva A, García C, Paulés AB, Vicente M, Megías M, Reyes G, De Villalonga P, Agell N, Lluís F, Bachs O, Capellà G. Disruption of the antiproliferative TGF-signaling pathways in human pancreatic cancer.Oncogene, 17, 1969-1978, 1998.

Jaumot M, Estanyol JM, Casanovas O, Graña X, Agell N, Bachs O. The cell cycle inhibitor P21 CIP1 is phosphorylated by cyclin A-CDK2 complexes.Biochemical and biophysical research communications, 241, 434-438, 1997

Taulés M, Rodríguez A, Rius E, Estanyol JM, Casanovas O, Sacks DB, Pérez-Payá E, Bachs O, Agell N. Calmodulin binds to p21Cip1 and is involved in the regulation of its intranuclear localization.J.Biological Chemistry, 274, 24445-24448, 1999

Miró F, Lelong JC, Pancetti F, Roher N, Duthu A, Plana M, Bourdon JC, Bachs O, May E, Itarte E. Tumour suppressor protein P53 released by nuclease digestion increases at the onset of rat liver regeneration.Journal of hepatology, 31, 306-314, 1999

Jaumot M, Estañol JM, Serratosa J, Agell N, Bachs O. Activation of CDK4 and CDK2 during rat liver regeneration is associated with intranuclear rearrangements of cyclin-CDK complexes.Hepatology, 29, 385-395, 1999

Bosch M, Gil J, Bachs O, Agell N. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of P21 CIP1.Journal of biological chemistry, 273, 22145-22150, 1998

De Villalonga P, Rius E, Bachs O, Agell N. (LYS 61) N-RAS is able to induce full activation and nuclear accumulation of CDK4 in NIH3T3 cells.Oncogene, 19, 690-699, 2000

Estanyol JM, Jaumot M, Casanovas O, Rodríguez A, Agell N, Bachs O. The protein set regulates de inhibitory effect of p21Cip1 on cyclin E-CDK2 activity J.Biological Chemistry, 274, 33161-33165, 1999

Estanyol JM, Agell N, Bachs O. Nuclear proteins distinguish normal T lymphocytes from lymphoblastoid cells.Cancer research 57, 1-7, 1997

Castro A, Faura M, Agell N, Renau-Piqueras J, Bachs O. LA/SS-B is a calmodulin-binding protein.Cell calcium, 20, 493-500, 1996

Jaumot M, Agell N, Bachs O. Putative nuclear CDK2 substrates in normal and transformed cells.Biochemical and biophysical research communications, 219, 560-564, 1996

López-Girona A, Bachs O, Agell N. Calmodulin is involved in the induction of DNA Polymerases (and activities in normal rat kidney cells activated to proliferate.Biochemical and biophysical research communications, 217, 566-574, 1995

Taulés M, Rius E, Talaya D, López-Girona A, Bachs O, Agell N. Calmodulin is essential for the activity and nuclear accumulation of CDK4 during G1.Journal biological chemistry, 273, 33279-33286, 1998

López-Girona A, Bosch M, Bachs O, Agell N. Addition of calmodulin antagonists to NRK cells during G1 inhibits proliferating cell nuclear antigen expression.Cell calcium, 18,30-40, 1995

Portoles M, Faura M, Renau-Piqueras J, lborra FJ, Sáez R, Guerri C, Serratosa J, Rius E, Bachs O. Nuclear calmodulin/62 kda calmodulin-binding protein complexes in interphasic and mitotic cells.Journal of cell science, 107, 3601-3614, 1994

Bosser R, Faura M, Serratosa J, Renau-Piqueras J, Pruschy M, Bachs O. The phosphorylation of rat liver heterogeneous nuclear ribonucleoproteins A2 and C can be modulated by calmodulin.Molecular and cellular biology, 15, 661-670, 1995

Dr  Montserrat Baiget Bastus

Díez Gibert O, Machuca L, Navarro MA. Caracterización del gen BRCA1 y su interés en el cáncer de mama hereditario.Med Clin (Bare) 1996; 107: 623-7.

Mazoyer S and The BRCA1 exon 13 duplication screening group. The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations.Am J Hum Genet 2000; 67: 207-12.

Díez O, Del Río E, Domènech M, Hernández E, Sanz J, Brunet J, Alonso MC, Baiget M. Mutaciones en el gen BRCA1 en mujeres españolas jóvenes con cáncer de mama.Med Clin (Barc) 1999; 112: 51-4.

Díez O, Doménech M, Alonso MC, Brunet J, Sanz J, Cortés J, Del Río E, Baiget M. ldentification of the 185delAG BRCA1 mutation in a Spanish Gypsy population.Hum Genet 1998; 103: 707-8.

Díez O, Brunet J, Sanz J, Del Río E, Alonso MC, Baiget M. Differences in the phenotypic expression of a new BRCAI mutation in identical twins.The Lancet 1997; 9079: 713.

Osorio A, Robledo M, Albertos J, Díez O, Alonso C, Baiget M, Benítez J. Molecular analysis of the six most recurrent mutations in the BRCAI gene in 87 spanish breast/ovarian cancer families.Cancer Lett 1998; 123: 153-8.

Díez O, Del Río E, Sanz J, Cortés J, Brunet J, Alonso MC, Baiget M. Identificación de una nueva mutación en el gen BRCA2 mediante análisis de la proteína truncada en una familia española con cáncer de mama hereditario.Med Clin (Barc) 1999; 112: 179-81

Díez O, Cortés J, Doménech M, Del Río E, Pericay C, Brunet J, Alonso MC, Baiget M. BRCA2 germ-Iine mutations in male breast cancer patients.Ann Oncol 2000; 11: 1-4.

Díez O, Cortés J, Doménech M, Brunet J, Del Río E, Pericay C, Sanz J, Alonso MC, Baiget M. BRCA1 analysis in 83 Spanish breast and breast/ovarian cancer familles IntJ. Cancer. 1999; 83: 465-9.

Díez O, Doménech M, Cortés J, Del Río E, Brunet J, Alonso MC, Baiget M. Two contiguosly located germlíne BRCA1 mutations in a Spanish early-onset breast cancer family.Cancer Lett 1999; 142: 71-3.

Díez O, Osorio A, Robledo M, Barroso A, Doménech M, Cortés J, Albertos J, Sanz J, Brunet J, Sanromán JM, Alonso C, Baiget M, Benítez M. Prevalence of BRCA1 and BRCA2 Jewísh mutations in Spanish breast cancer patients.Br J Cancer 1999; 79; 1302-3.

Dr  Josep Balart Serra

Balart J, Ares C, De los Inocentes RM, Capellá G, Lluís F, Craven-Bartle J. Efecto de la irradiación y del 5-fluorouracilo sobre los xenotumores humanos de colon HCT-15 y pancreático MIA PaCa-2.Oncologia 20:94; 1997

Dr  Ramon Bartrons Bach

Castaño E, Bartrons R, Gil J. Inhibition of cyclooxygenase-2 decreases DNA synthesis induced by platelet-derived growth factor in swiss 3T3 fibroblasts.Journal Pharmacology & Experimental Therapeutics (2000) 293: 509-513

Castaño E, Dalmau M, Barragan M, Pueyo G, Bartrons R, Gil J. Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells.British Journal of Cancer (1999) 81: 294-299.

Castaño E, Dalmau M, Martí M, Berrocal F, Bartrons R, Gil J. Inhibition of DNA synthesis by aspirin in swiss 3T3 fibroblasts.Journal Pharmacology & Experimental Therapeutics (1997) 280: 366-372

Bartrons R, Castaño E, Pueyo G, Gil J. Aspirina i antiinflamatoris no esteroïdals en la prevenció del càncer colorectal.Patologia Molecular. R. Bartrons Ed. Treballs de la Societat Catalana de Biologia (1999) 49: 97-111.

Dr  Jerónimo Blanco Fernández

Martín Satue M, Castellarnau C, Blanco J. Overexpression of ? (1,3) Fucosyltransferase VII is suffcient for the acquisition of lung colonization phenotype in human lung adenocarcicoma HAL-24.Luc cells Brit. J. Cancer, (1999), 80, 1169-1174

Rubio N, Martínez Villacampa M, Blanco J. Traffic to limph nodes of PC-3 prostate tumor cells in nude mic. Visualized using the luciferase gene as a tumor cell marker.Lab. Invest. (1998), 78:1315-1325

Martín Satue M, Marrugat R, Cancelas JA, Blanco J. Enhanced expression of ? (1,3) Fucosyltransferase genes correlates with e-selectin-mediated adhesion and metastic potential of human lung adenocarcicoma cells. Cancer research 1998), 58: 1544-1550

Martín Satue M, Blanco J. Identification of semaforin e gene expression in metastatic human lung adenocarcicoma cells by Mrna differential display.Journal of Surgical Oncology (1999), 72, 18-23.

Rubio N, Blanco J. Simultaneous selection and cloning of transfected eukariotic cells.Biothecniques (1996), 21:622-624

Dr  Elias Campo Güerri

Rey MJ, Fernández PL, Jares J, Muñoz M, Nadal A, Periró N, Nayach I, Mallofré C, Muntané J, Campo E, Cardesa A. p21Waf1/Cip1 is associated with cyclin D1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma.J Pathol 1998; 184:265-271.

Fernández PL, Merino MJ, Gómez M, Campo E, Medina T, Castronovo V, Sanjuan X, Cardesa A, Liu F, Sobel M. Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue.J Pathol 1997; 181: 80-86.

Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, López-Otín C. Cathepsin L2, a novel human cystein proteinase produced by breast and colorectal carcinomas.Cancer Res 1998; 58:1624-1630. 11.

Beà S, Ribas M, Hernández JM, Bosch F, Pinyol M, Hernández L, García JL, Flores T, González M, López-Guillermo A, Piris MA, Cardesa A, Montserrat M, Miró R, Campo E. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants.Blood 1999; 93:4365-4374

Pinyol M, Cobo F, Bea S, Jares J, Nayach I, Fernández PL, Montserrat E, Cardesa A, Campo E. p16 MTS1/CDK4I gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkins lymphomas.Blood 1998, 91:2977-2984

Cazorla M, Hernández L, Nadal A, Balbín M, López JM, Vizoso F, Fernández PL, Iwata K, Cardesa A, López-Otín C, Campo E. Collagenase-3 expression is associated with advanced local invasion in human squamous cel carcinomas of the larynx.J Pathol 1998; 186:144-150.

Fernández PL, Jares P, Rey MJ, Campo E, Cardesa A. Cell cycle regulators and their abnormalities in breast cancer.Mol Pathol 19998; 51:305-309

SanJuan X, Fernández PL, Miquel R, Muñoz J, Castronovo V, Menard S, Cardesa A, Campo E. Overexpression of the 67-Kd laminin receptor correlates with tumor progression in human colorectal carcinoma.J Pathol 1996; 179:376-380

Terol MJ, Cid MC, López-Guillermo A, Juan M, Bosch F, Vives J, Cardesa A, Montserrat E, Campo E. Intercellular adhesion molecule ICAM-3/CD50) in lymphoproliferative and solid tumors.Tissue Ag 1996; 48:271-277

Hernández S, Fernández Ll, Beà S, Cazorla M, Fernández PL, Nadal A, Muntané J, Mallofré C, Montserrat E, Cardesa A, Campo E. cdc25 cell cycle-activating phosphatases and c-myc expression in human non-Hodgkins lymphomas.Cancer Res 1998; 58:1762-1767

Terol MJ, López-Guillermo A, Bosch F, Villamor N, Cid MC, Rozman C, Campo E, Montserrat E. Expression of the adhesion molecule ICAM-1 in non-Hodgkins lymphoma: relationship with tumor dissemination and prognostic importance.J Clin Oncol 1998; 16:35-40.

Sanjuan X, Fernández PL, Castells A, Castronovo V, Van den Brule F, Liu FT, Cardesa A, Campo E. Differential expression of galectin 3 and galectin 1 in colorectal cancer progression.Gastroenterology 1997; 113:1906-15.

Jares P, Rey MJ, Fernández PL, Campo E, Nadal A, Muñoz M, Mallofre C, Muntane J, Nayach N, Estapé J, Cardesa A. Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: correlation with tumor proliferation and estrogen receptor status.J Pathol 1997; 182:160-166.

Jares P, Fernández PL, Nadal A, Cazorla M, Hernández L, Pinyol M, Hernández S, Traserra J, Cardesa A, Campo E. p16MTS1/CDK41 mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx.Oncogene 1997; 15:1445-1453.

Dr  Gabriel Capella Munart

Tórtola S, Marcuello E, Aiza G, González S, Capellá G, Peinado MA. Sketching gene expression profiles in human colorectal cancer by RNA fingerprinting.Oncogene 18: 4383-4387, 1999.

González-García I, Moreno V, Navarro M, Martí-Ragué J, Marcuello E, Benasco C, Campos O, Capellá G, Peinado MA. A model for microsatellite instability diagnosis standardization: application in colorectal cancer.J Natl Cancer Inst 92:544-549, 2000

Esteller M, Tórtola S, Toyota M, Capellá G, Peinado MA, Kinzler KW, Baylin S, Herman JG. Hypermethylation-associated inactivation of p14ARF suggests a tumour suppressor role independent of p16INK4A and p53 status.Cancer Res 60:129-133, 2000

Palicio M, Blanco I, Tórtola S, González I, Marcuello E, Brunet J, Lluís F, González-Aguilera JJ, Peinado MA, Capellá G. Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer.Br J. Cancer 82:535-537, 2000

Puig P, Urgell E, Capellá G, Sancho FJ, Pujol J, Boadas B, Farré A, Lluís F, González-Sastre F, Mora J. A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.q.Int J Cancer 85:73-77, 2000.

Arribas R, Ribas R, Risques RA, Masramón L, Tórtola S, Marcuello E, Aiza G, Miró E, Capellá E, Peinado MA. Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival.Clin Cancer Res 5: 3454-3459, 1999.

Puig P, Urgell E, Capellá G, Villanueva A, Boadas J, González-Sastre F, Mora J. Improved detection of K-ras codon 12 mutations. Utility in non-invasive diagnosis of colorectal cancer.Lab Invest 79:617-618, 1999.

Tórtola S, Capellà G, Marcuello E, Günther K, Aiza G, Masramón L, Reymond LA, Peinado MA. Analysis of differential gene expression in human colorectal tumor tissues by RNA arbitrarily primed PCR: Technical assessment.Lab Invest 78:309-317, 1998

Tórtola S, Marcuello E, González I, Reyes G, Arribas R, Aiza G, Sancho FJ, Peinado MA, Capellá G. p53 and K-ras mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.J Clin Oncol 17: 1375-1381, 1999.

Arribas R, Capellà C, Tórtola S, Masramón L, Grizzle W, Perucho M, Peinado MA. Assessment of genomic damage in colorectal cancer by DNA fingerprinting: prognostic applications. J Clin Oncol 15: 3230-3240, 1997

Esteller M, Toyota M, Sánchez-Céspedes M, Capellá G, Peinado MA, Neil Watkins D, Issa JP, Sidransky D, Baylin SB, Herman JG. Inactivation of the DNA repair gene 06-Methylguanine-DNA Methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.Cancer Res 60:2368-2371, 2000.

Capellá G, Villanueva A, Reyes G, Mora J, Peinado MA, Lluís F. Detección de mutaciones en oncogenes: aplicaciones diagnósticas y pronósticas. La genética molecular en el diangóstico de las patologías humanas: Estrategias y tecnologías.Mendez Pelto J (ed). Universidad A Coruña, Coruña 1996. pp-125-140.

Capellá G, Marcuello E, Peinado MA, Lluís F. Biología molecular: aplicaciones clínicas en el cáncer de cólon. Cáncer 96. Actualizaciones en Oncología.González Barón M (ed). Fundación BBV, Bilbao 1997. p.319-331.

Arribas R, Capellá G, Perucho M, Peinado MA. Inestabilidad genómica en el cáncer colorrectal.Gastro 97. Pérez-Piqueras J, Herrerías JM, Arenas JI, Díaz-Rubio M (eds). ELA, Madrid, 1997. p.145-152.

Tarafa G, Villanueva A, Farré L, Rodríguez J, Musulén E, Reyes G, Seminago R, Olmedo E, Paulés AB, Peinado MA, Bachs O, Capellá G. DCC and Smad4 alterations in human colorectal and pancreatic tumour dissemination.Oncogene 19:546-555, 2000

Arribas R, Risques RA, González-García I, Masramon L, Aiza G, Ribas R, Capellá G, Peinado MA. Tracking recurrent genetic quantitative genomic alterations in colorectal cancer: allelic losses in chromosome 4 correlate with tumour aggressiveness.Lab Invest 79: 111-122, 1999

Altés A, Gimferrer, E, Capellá G, Barceló MJ, Baiget M. Colorectal Cancer and HFE gene mutations.Hematologica 84: 479-480, 1999

Capellá G, González S, Marcuello E, Peinado MA, Lluís F. Análisis genético y moduladores de la progresión tumoral. Nuevas perspectivas en el enfoque de la neoplasia colónica.Nuevas Fronteras en Enfermedades Digestivas, Doyma, Barcelona 1996. Piqué JM (ed).

Dr  Josep Carreras Barnés

Durany N, Joseph J, Jiménez OM, Climent F, Fernández PL, Rivera F, Carreras J. Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma.British Journal of Cancer (2000) 82(1), 20-27(c) 2000 Cancer Research Campaign Article no. bjoc. 1999. 0871

Dr  Jordi Casanova Roca

Alsina B, Corominas M, Berry MJ, Baguñà J, Serras F. Disruption of selenoprotein biosynthesis affects cell proliferation in the imaginal discs and brain of Drosophila melanogaster.Journal of Cell Science 112, 2875-2884

Alsina B, Serras F, Baguñà J, Corominas M. The gene, encoding the Drosophila melanogaster homologue of selenophosphate synthetase, is involved in imaginal disc morphogenesis.Mol. Gen. Genet. 257(2):113-123.

Roch F, Serras F, Cifuentes FJ, Corominas M, Alsina B, Amorós M, López-Varea A, Hernández R, Guerra D, Cavicchi S, Baguñá J, García-Bellido A. Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs.Mol. Gen. Genet. 257(2):103--112.

Llimargas M, Casanova J. EGF signalling regulates cell invagination as well as cell migration during formation of tracheal system in Drosophila.Development, Genes and Evolution 209, 174-179.1999

Furriols M, Casali A, Casanova J. Dissecting the mechanism of torso activation.Mechanisms of Development 70, 111-118.1998

Llimargas M, Casanova J. vvl, a POU domain transcription factor, regulates different transduction pathways required for tracheal branching in Drosophila.Development 124, 3273-3281. 1997

Furriols M, Sprenger F, Casanova J. Variation in the number of activated torso receptors correlates with differential gene expression.Development 122, 2313-2317. 1996

Dr  Antoni Castells i Garangou

Castells A, Puig P, Móra J, Boadas J, Boix L, Urgel E, Solé M, Capellà G, Lluís F, Fernández-Cruz L, Navarro S, Farré A. K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.J Clin Oncol 1999; 17:578-584.

Cubiella J, Castells A, Fondevila C, Sans M, Sabater L, Navarro S, Fernández-Cruz L. Prognostic factors in nonresectable pancreatic adenocarcinoma: a rationale to design therapeutic trials.Am J Gastroenterol 1999; 94:1271-1278

Castells A, Bessa X, Daniels M, Ascaso C, Lacy AM, García-Valdecasas JC, Gargallo L, Novell F, Astudillo E, Filella X, Piqué JM. Value of postoperative surveillance after radical surgery for colorectal cancer. Results of a cohort study.Dis Colon Rectum 1998; 41:714-724.

Castells A, Boix L, Bessa X, Gargallo L, Piqué JM. Detection of colonic cells in peripheral blood of colorectal cancer patients by means of reverse transcriptase and polymerase chain reaction.Br J Cancer 1998; 78:1368-1372.

Fondevila C, Cubiella J, Sans M, Sabater L, Ayuso C, Castells A, Navarro S, Fernández-Cruz L, Terés J. Utilidad de la ultrasonografía y la tomografía computadorizada en la predicción de la resecabilidad del carcinoma pancreático.Med Clín (Barc) 1998; 111:604-607.

Sala M, Castells A, Bessa X, Gargallo L, Piqué JM. Situación actual del cribado del cáncer colorrectal en Catalunya. Resultados de una encuesta poblacional.Gastroenterol Hepatol 1998; 21:427-431.

Dr  Antonio Celada Cotarelo

Borras F, Lloberas J, Maki RA, Celada A. Inhibition of I-Ab gene expression by the transcription factor PU.1.Journal of Biological Chemistry 270: 24385-24391, 1995 (I.I. = 7,199).

Lloberas J, Soler C, Celada A. The key role of PU.1/Spi-1 in B cells, myeloid cells and macrophages.Immunology Today 20: 184-189, 1999 (I.I.=15,439).

Celada A, Borras F, Soler C, Lloberas J, Klemsz MJ, Van Beveren C, McKercher SR, Maki RA. The transcription factor PU.1 is involved in macrophage proliferation.Journal of Experimental Medecine 184: 61-69,1996 (I.I.=15,882).

Valledor AF, Borras FE, Cullell-Young M, Celada A. Transcription factors that regulate monocyte-macrophage differentiation.Journal of Leukocyte Biology 63: 405-417, 1998 (I.I.=4,262).

Maria Cinta Cid Xutgla

Terol MJ, Cid MC, López-Guillermo A, Juan M, Yagüe J, Miralles A, Vilella R, Vives J, Cardesa A, Montserrat E, Campo E. Expression of intercellular adhesion molecule-3 (ICAM-3/CD50) in malignant lymphoproliferative disorders and solid tumors.Tissue Ag 1996; 48:271-277.

Coll-Vinent B, Cebrián M, Cid MC, Font C, Esparza J, Juan M, Yagüe J, Urbano-Márquez A, Grau JM. Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa.Arthritis Rheum 1998; 41:435-444.

Terol MJ, López-Guillermo A, Bosch F, Villamor N, Cid MC, Rozman C, Campo E, Montserrat E. Expression of the adhesion molecule ICAM-1 in non-Hodgkins lymphoma: relationship with tumor dissemination and prognostic importance.J Clin Oncol 1998; 16:35-40.

Gallart T, Roelcke D, Blay M, Pereira A, Martínez A, Massó O, Viñas O, Cid M, Esparza J, Molina R, Barceló J. Anti-Sia-Ib (Anti-Gd) cold agglutinins bind the domain neu Naca2-3gal in sialyl Iewisx, sialyl Lewisa, and related carbohydrates on nucleated cells and in soluble cancer-associated mucins.Blood 1997; 90:1576-1587.

Esparza J, Vilardell C, Calvo J, Juan M, Vives J, Urbano-Márquez A, Yagüe J, Cid MC. Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MTI-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways.Blood 1999; 94:2754-2766

Schnaper HW, McGowan KA, Hubchak SC, Cid MC, Kleinman HK, KimSchulze S. Endothelial cells, estrogen and angiogenesis. En Nitric Oxide, Cytochromes P450 and gonadal steroids.Ed V Habenicht 1997. Springer-Verlag. Heidelberg, New York. pp 283-301.

Dr  M. Dolors Coll Sandiumenge

Triviño E, Guitart M, Egozcue J, Coll MD. Characterization by FISH of a t(5;13) in a patient with bilateral Retinoblastoma.Cancer Genet Cytogenet 96, 23-25, 1997

Triviño E, Escudero T, Guitart M, Domínguez MC, Coll MD. FISH and molecular studies of Retinoblastoma.Europ J Hum Genet 4, 49, 1996

Dr  Joan Xavier Comella Carnice

Boix J, Llecha N, Yuste VJ, Comella JX. Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines.Neuropharmacology 36:811-821. 1997.

Sanz-Rodríguez C, Boix J, Comella JX. Cytosine arabinoside is neurotoxic to chick embryo spinal cord motoneurons in culture.Neuroscience Letters 223:141-144. 1997.

Dr  Gustavo Egea Guri

Ayala I, Babià T, Baldassarre M, Pompeo A, Fabra A, Kok JW, Luini A, Buccione R, Egea G. Morphological and biochemical analysis of the secretory pathway in melanoma cells with distinct metastatic potential.Febs Letters 451:315-320. 1999.

Badia T, Ayala I, Valderrama F, Mato E, Bosche M, Santaren JF, Renau-Piqueras J, Kok JW, Thomson T, Egea G. N-Ras induces alterations in the Golgi complex architecture and in constitutive protein transport.Journal of Cell Science 112(4): 477-489 1999.

Medna M, Vélez D, Asenjo JA, Egea G, Real FX, Gil J, Subiza JL. Human colon adenocarcinoma express a muc1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells.Cancer Research 59:1061-1070 1999.

Dr  Xavier Estivill Pallejà

Ruíz A, Puig S, Lynch M, Castel T, Estivill X. Retention of the CDKN2A locus and low frequency of point mutations in primary and metastasic cutaneous malignant melanoma.International Journal of Cancer (1998) 76:312-316.

Ruíz A, Nadal M, Puig X, Estivill X. Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region.Gene (1999) 239:155-161.

Ruíz A, Puig S, Lynch M, Castel T, Estivill X. Retention of the CDKN2A locus and low frequency of point mutations in primary and metastasic cutaneous malignant melanoma.International Journal of Cancer (1998) 76:312-316.

Puig S, Ruíz A, Castel T, Volpini V, Malvehy J, Cardellach F, Lynch M, Mascaró JM, Estivill X. Inherited susceptibility to several cancers but absence of linkage between dysplastic nevus syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A (P16INK4A) gene.Human Genetics (1997) 101:359-364.

A Ruiz, S Puig, J Malvehy, C Lázaro, M Lynch, AM Giménez-Arnau, L . Puig, J Sánchez-Conejo, x Estivill, T Castel. CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasies, Journal of Medical Genetics (1999) 36:490-493

A Ruiz, MA Pujana, X Estivill. Isolation and characterization of a novel human gene (C9orf11) on chromosome 9p21, a region frequently deleted in human cancer. Biochemical et Byophisica Acta (2000) 1517: 128-134

Dr  Àngels Fabra Fres

Llorens A, Vinyals A, Alía P, Lopez-Barcons L, Gonzalez-Garrigues M, Fabra A. Metastatic ability of MXT mouse mammary subpopulations is related to clonal expression and membrane-association of Gelatinase A Molec.Carcinogenesis 19:54-66, 1997.

Sierra A, Price JE, Garcia-Ramirez M, Méndez O, López Ll, Fabra A. Astrocyte-derived cytokines contribute to the metastatic brain specificity of breast cancer cells.Laboratory Invest. 77:357-368, 1997

Fabra A, Vinyals A, Colomer R. Mecanismos de Invasion y Metastasis, en Tratado de oncologia Médica.Spain Ed: Nova Sidonia Oncologia, 1999

Mollinedo A, Nakajima M, Llorens A, Barbosa E, Callejo S, Gajate C, Fabra A. Major co-localization of the extracellular matrix degradative enzymes heparanase and gelatinase in the tertiary granules of human neutrophils.Biochemical J. 327, 917-923, 1997.

Moreno A, Lloveras B, Figueras A, Escobedo A, Ramón JM, Sierra A, Fabra A. Ductal carcinoma in situ of the breast: Correlation between histologic classifications and biologic markers.Modern Pathology, 10:1088-1092, 1997

Shi B, Alia P, Vinyals A, Llorens A, Adrover M, Fabra A. Differentially expressed MHC class II gene in highly metastatic cells of human breast carcinoma is caused by loss of expression of CIITA transactivator.J. of Immunol. 2000.

Vinyals A, Peinado MA, González Garrigues M, Monzó M, Bonfil DR, Fabra A. Failure of wild-type p53 cancer gene therapy in human cancer cells expressing mutant p53 protein.Gene Therapy.6, 22-33,1999.

Llorens A, Rodrigo I, Lopez Barcons Ll, Gonzalez-Garrigues M, Lozano E, Vinyals A, Quintanilla M, Cano A, Fabra A. Downregulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to MMP-9 gelatinase expression.Lab. Invest. vol 7, 9, 1131-1142, 1998.

Vinyals A, Alía P, Llorens A, González-Garrigues M, Masramón L, Peinado MA, Fabra A. Detection of differentially expressed gelatinase A in Metastatic and non-metastatic subpopulations of mouse mammary carcinomas by Target RNA Arbitrarily Primed Polymerase Chain Reaction (TRAP-PCR).Clinical and Experimental Metastasis 16, 603-611,1998.

Dr  Jordi Félez Brugués

Félez J, Jardí M, Arza B. Angiostatina y su actividad anti-tumoral.Medicina Clínica, 114: 431-6, 2000

Sinniger V, Merton E, Fàbregas F, Félez J, Longstaff C. Regulation of tissue plasminogen activator (tPA) activity by cells: domains responsible for binding and mechanism of stimulation.J Biol Chem 274:12414-12422, 1999

Arza B, Félez J. The emerging impact of phage display technology in thrombosis and haemostasis.Thromb Haemost 80:354-65, 1998

Longstaff C, Merton ER, Fàbregas F, Félez J. Characterization of cell associated plasminogen activation catalysed by urokinase-type plasminogen activator (uPA) but independent of uPAR.CD87 Blood 93:3839-3846, 1999

Félez J. Plasminogen binding to cell surfaces Fibrinolysis & Proteolysis.12(4):183-189, 1998.

Félez J. Angiostatina: angiogenesis y actividad anti-tumoral. Rev Iberoam.Tromb Hemost 11(1): 50-53, 1998

Félez J, ed. La tombolisis 30 años más tarde: la perspectiva del especialista en coagulación.Editorial Edikamed, Granada, 1998

Arza B, Félez J, López-Alemany R, Miles LA, Muñoz-Cánoves P. Identification of an epitope of a-Enolase (a candidate plasminogen receptor) by phage display.Thromb Haemost 78, 1097-1103, 1997

Muñoz-Cánoves P, Miralles F, Baiget M, Félez J. Inhibition of urokinase-type plasminogen activator (uPA) abrogates myogenesis in vitro.Thromb Haemost 77: 526-534, 1997

Félez J. Angisotatin: angiogenesis and anti-tumoral activity.Haematologica 83 (Supl. 1): 358-361, 1998

López-Pedrera CH, Jardí M, Inglés-Esteve J, Muñoz-Cánoves P, Dorado G, Velasco F, Félez J. Characterization of tissue factor expression on the human endothelial cell line ECV304 AM. J.Hematol 56:71-78, 1997

Dr  Pedro Luis Fernández Ruiz

Fernández PL. El control de la proliferación celular y sus alteraciones en el cáncer de mama.Editorial Neoplasia 12:115-117, 1995.

Jares P, Rey MJ, Fernández PL, Campo E, Nadal A, Muñoz M, Mallofré C, Muntané J, Nayach N, Estapé J, Cardesa A. Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: correlation with tumor proliferation and estrogen receptor status.J Pathol 182:160-166, 1997.

Rey MJ, Fernández PL, Jares P, Muñoz M, Nadal A, Peiró N, Nayach I, Mallofré C, Muntané J, Campo E, Estapé J, Cardesa A. 21WAF1/Cip1 is associated with cyclin D1CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma.J Pathol 184:265-271, 1998.

Fernández PL, Jares P, Rey MJ, Campo E, Cardesa A. Cell cycle regulators and their abnormalities in breast cancer.(Review). J Clin Pathol:Mol Path 51:305-309, 1998.

Dr  Isidro Ferrer Abizanda

Ferrer I, Olivé M, Blanco R, Cinós C, Planas AM. Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat.Mol Brain Res 38: 91-100 (1996)

Ferrer I, Barrón S, Rodríguez-Farré E, Planas AM. Ionizing radiation-induced apoptosis is associated with c-Jun expression and c-Jun/AP1 activation in the developing cerebellum of the rat.Neurosci Lett 202: 105-108 (1995)

Ferrer I, Pozas E, Ballabriga J, Planas AM. Strong c-Jun/AP-1 immunoreactivity is restricted to apoptotic cells following intracerebral ibotenic acid injection in developing rats.Neurosci Res 28: 21-31 (1997)

Ferrer I. Cell death in the normal developing brain, and following ionizing radiation, methylazoxymethanol acetate, and hypoxia-ischaemia in the rat.Neuropathol Appl Neurobiol 22:489-494 (1996)

Ferrer I, Olivé M, Ribera J, Planas AM. Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain.Eur J Neurosci 8: 1286-1298 (1996)

Ferrer I, Pozas E, Martí M, Blanco R, Planas AM. Methylazoxymethanol acetate-induced apoptosis in the external granule cell layer of the developing cerebellum of the rat is associated with strong c-Jun expression and formation of high molecular weight c-Jun complexes.J Neuropathol Exp Neurol 56: 1-9 (1997)

Ferrer I, Pozas E, Planas AM. Ubiquitination of apoptotic cells in the developing cerebellum of the rat following ionizing radiation or methylazoxymethanol injection.Acta Neuropathol 93: 402-407 (1997)

Ferrer I, Blanco S, Rivera R, Carmona M, Ballabriga J, Olivé M, Planas AM. CREB-1 and CREB-2 immunoreactivity in the rat brain.Brain Res 712: 159-164 (1996)

Ferrer I, Seguí J, Olivé M. Strong c-Jun immunoreactivity is associated with apoptotic cell death in human tumors of the central nervous system.Neurosci Lett 214: 49-52 (1996)

Pozas E, Ballabriga J, Planas AM, Ferrer I. Kainic acid-induced excitotoxicity is associated with a complex c-Fos and c-Jun response which does not preclude either cell death or survival.J Neurobiol 33: 232-246 (1997)

Ferrer I, Planas AM, Pozas E. Radiation-induced apoptosis in developing rats and kainic acid-induced excitotoxicity in adult rats are associated with distinctive morphological and biochemical c-Jun/AP-1 (N) espression.Neuroscience 80: 449-458 (1997)

Dr  Cristina Fillat Fonts

Carrió M, Romagosa A, Mercadé E, Mazo A, Nadal M, Gómez-Foix AM, Fillat C. Enhanced pancreatic tumor regression by a combination of adenovirus and retroviruss-mediated delivery of the herpes simplex virus thymidine kinase gene.Gene Therapy (1999) 6:547-554.

Cascalló C, Mercadé E, Capellà G, Lluís F, Fillat C, Gómez-Foix AM, Mazo A. Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells.Cancer Gene Therapy (1999) 6:428-436.

Dr  José Ramón Germá Lluch

Garcia del Muro X, Torregrosa A, Muñoz J, Castellsagué X, Condom E, Vigués F, Arance A, Fabra A, Germà JR. Prognostic value of the expression of E-cadherin and Beta-catenin in bladder cancer.European Journal of Cancer 2000; 36: 357-362.

Dr  Anna Maria Gómez Foix

Cascalló M, Mercadé E, Carrió M, Gómez-Foix AM, Fillat C, Mazo A. Genetic background determines the response to adenovirus-mediated delivery of wild-type p53 expression in pancreatic tumor cells.Cancer Gene Therapy (1999) 6, 428-436.

Carrió M, Romagosa A, Mercadé E, Mazo A, Nadal M, Gómez-Foix AM, Fillat C. Enhanced pancreatic tumor regression by combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.Gene Therapy (1999) 6, 547-553.

Dr  Alberto Grañena Batista

González-Barca E, Grañena A, Fernández-Sevilla A, Moreno V, Salar A, Rueda F, García J. Low-dose subcutaneous interleukin-2 in patients with minimal residual lymphoid neoplasm disease.Eur J Haematol 1999.- 62: 231-238 Printed in UK - all rights reserved ISSN 0902-4441

Dr  Marc Isamat Riviere

Muñoz-Marmol AM, Strasser G, Isamat M, Coulombe PA, Yang Y, Roca X, Vela E, Mate JL, Coll J, Fernández-Figueras MT, Navas-Palacios JJ, Ariza A, Fuchs E. A dysfunctional mutation in a patient with severe generalized Myopathy.Proceedings of the National Academy of Sciences (USA)1998, 95:11312-11317

Roca X, Mate JL, Ariza A, Muñoz-Marmol AM, Von Uexkull-Güldenband C, Pellicer I, Navas-Palacios JJ, Isamat M. CD44 isoform expression follows two alternative splicing pathways in breast tissue.American Journal of Pathology 1998, 158:183-190

Dr  Conxita Lázaro García

Ars E, Serra E, García J, Kruyer H, Gaona A, Lázaro C, Estivill X. Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1.Human Molecular Genetics (2000) 9:237-247.

Correa C, Brems H, Lázaro C, Estivill X, Clementi M, Mason M, Rutkowski JL, Marynen P, Legius E. Molecular studies in 20 submicroscopic neurofibromatosis type 1 gene deletions.Human Mutation (1999) 14:387-393.

Ars E, Kruyer H, Gaona A, Serra E, Lázaro C, Estivill X. Prenatal Diagnosis of Sporadic Neurofibromatosis Type 1 (NF1) by RNA and DNA Analysis of a Splicing Mutation.Prenatal Diagnosis (1999) 19:739-742.

Lázaro C, Gaona A, Ainsworth P, Tenconi R, Vidaud D, Kruyer H, Ars E, Volpini V, Estivill X. Sex differences in mutational rate and mutational mechanism in the NF1 gene in neurofibromatotis type 1 patients.Human Genetics (1996) 98:696-699.

Ars E, Kruyer H, Gaona A, Casquero P, Rosell J, Volpini V, Serra E, Lázaro C, Estivill X. A Clinical Variant of Neurofibromatosis Type 1: Familial Spinal Neurofibromatosis with a Frameshift Mutation in the NF1 Gene.American Journal Human Genetics (1998) 62:834-841.

Lázaro C, Serra E, Ars E, Estivill X. Patologia molecular de la neurofibromatosi de tipus 1.Treballs de la Societat Catalana de Biologia (1999) 49:163-192.

Serra E, Puig S, Otero D, Gaona A, Kruyer H, Ars E, Estivill X, Lázaro C. Confirmation of a double hit model for the NF1 gene in benign neurofibromas.American Journal of Human Genetics (1997) 61:512-519.

Dr  Alberto de Leiva Hidalgo

Chico A, Gallart Ll, Martín-Campos JM, Catasús Ll, Mayoral C, Mato E, Tortosa F, Bernà Ll, Rodríguez-Espinosa J, Blanco-Vaca F, Matías-Guiu X. Genetic, clinical, and biochemical analysis of unrelated spanish families with multiple endocrine neoplasia type I. (c).2000AACE

Mato E, Matías-Guiu X, Chico A, Webb SM, Cabezas R, Berná Ll, De Leiva A. Somatostatin and Somatostatin Receptor Subtype Gene. Expression in Medullary Thyroid Carcinoma 0021-972X/98/$03. 00/0 Journal of Clinical Endocrinology and Metabolism.Copyright (c) 1998 by The Endocrine Society Vol. 83, No, 7 Printed in USA.

Capellà C, Matías-Guiu X, Ampudia X, De Leiva A, Perucho M, Prat J. Ras Oncogene Mutations in Thyroid Tumors. Polymerase Chain. Reaction-Restriction-Fragment-Length Polymorphism.Analysis from Paraffin-Embedded Tissues Diagnostic Molecular- Pathology 5(1): 45~52. 1996 Lippincott-Raven Publishers, Philadelphia

Chico A, Gallart L, Mato E, Catasús L, Mayoral C, Martín-Campos J, Bernà L, Rodríguez-Espinosa J, Matías-Guiu X, Blanco F, De Leiva A. Grupo de Estudio de MEN1 del Hospital de Sant Pau. Neoplasia endocrino múltiple tipo 1: características clínicas y estudio genético.Endocrinologia. Vol. 46, núm. 3 1999

Matías-Guiu X, Villanueva A, Cuatrecasas M, Capellá G, De Leiva A, Prat J. p53 in a Thyroid Follicular Carcinoma with Foci of Poorly Differentiated and Anaplastic Carcinoma Path.Res. Pract. 192, 1242-1249 (1996)

Martín-Campos JM, Catasús Ll, Chico A, Mayoral C, Lagarda E, Gallart L, Mato E, Rodríguez-Espinosa J, Matías-Guiu X, De Leiva A. Molecular Pathology of Multiple Endocrine Neoplasia Type 1: Two Novel Germline Mutations and Updated Classification of Mutations Affecting MEN1.Gene Diagnostic Molecidar Pathology 8(4): 195-204, 1999 (c) 1999 Lippincott Wiiliams & Wilkins, Inc., Philadelphia

Garcia A, Matías-Guiu X, Cabezas R, Chico A, Prat J, Baiget M, De Leiva A. Molecular diagnosis of von Hippel-Lindau disease in a kindred with a predominance of familial phaeochromocytoma.Clinical Endocrinology (1997) 46, 359-363 (c) 1997 Blackwell Science Ltd

Tortosa F, Chico A , Rodríguez-Espinosa J, Ruscalleda J, De Leiva A and the MEN1 Study Group of the Hospital de la Santa Creu i Sant Pau of Barcelona. Letters to the Editors: Prevalence of MEN 1 in patients with prolactinoma.(c) 1999 Blackwell Science Ltd, Clinical Endocrinology, 50, 271.-272

Matías-Guiu X , Machin P, Pons C, Lagarda E, De Leiva A, Prat J. Sustentacular cells occur frequently in the familial form of medullary thyroid carcinoma.Journal of Pathology, vol. 184: 420-423 (1998)

Chico A, Gallart L, Mato E, Mayoral C, Martín-Campos JM, Catasús Ll, Rodríguez-Espinosa J, Matías-Guiu X, Blanco-Vaca Fr, De Leiva A. A novel germline mutation in exon 5 of the multiple endocrino neoplasia type 1 gene.J Mol Nted 1998 76:837 839 (c) Springer-Verlag 1998

Dr  Adela Mazo Sánchez

Cascalló M, Calbó J, Gelpí JL, Mazo A. Reintroduction of wt-p53 gene (Ad5CMV-p53) increases the cytotoxixity by apoptosis in human pancreatic tumour cells treated with genotoxic drugs.Cancer Gene Therapy, (2000) 7 (4) 545-556.

Mazo A. Terapia génica en cáncer de páncreas.Adela Gastroenterología, 99 pp. 267-272. Editorial Cantabria, 1999

Carrió M, Romagosa A, Mercadé E, Mazo A, Nadal M, Gómez-Foix AM, Fillat C. Enhanced pancreatic tumour regression by combination of adenovirus and retrovirus-mediated delivery of the herpex simplex virus thymidine kinase gene.Gene Therapy (1999) 6:547-554

Mazo A. Transferencia génica: ¿una alternativa para el tratamiento del cáncer de páncreas?.LXXXII Curso de la Escuela de Patología Digestiva. Editorial Prous, 1999.

Carrió Cascalló M, Mercadé E, Capellà G, Lluís F, Fillat C, Gómez-Foix AM, Mazo A. Genetic background determines the response to adenovirus-mediated wt-p53 expression in pancreatic tumour cells.Cancer Gene Therapy, (1999), 6 (5) 428-436.

Dr  Anna Messeguer Navarro

Vila MR, Nicolás A, Morote J, De Torres I, Meseguer A. Increased glyceraldehyde-3-phosphate dehydrogenase expression in renal cell carcinoma identified by RNA-based arbitrarily primed polymerase chain reaction.Cancer, 2000; 89:152-64

Dr  Josefina Mora Brugués

Puig P, Urgell E, Capellà G, Sancho FJ, Pujol J, Boadas J, Farré A, Lluís F, González-Sastre F, Mora J. A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.lnternational Journal of Cancer 2000; 85: 73-77.

Puig P, Urgell E, Capellà G, Víllanueva A, Grau A, Sancho FJ, Pujol J, Lluís F, González-Sastre F, Mora J. Improved detection of K-ras Codon 12 mutations in fecal exfoliated cells.Laboratori lnvestigation 1999; 79: 617-618.

Mora J, Puig P, Boadas J, Urgel E, Montserrat E, Lerma E, González-Sastre F, Lluís F, Farré A, Capellá G. K-ras gene mutations in the diagnosis of fine-needle aspirates of pancreatic masses: prospective study using two techniques with different detection limits.Clínical Chemistry 1998; 44: 2243-2248.

Castells A, Puig P, Mora J, Boadas J, Boix L, Urgell E, Solé M, Capellà G, Lluís F, Fernández-Cruz L, Navarro S, Farré A. K-ras in DNA extracted fram the plasma of patíents vvith pancreatie carcinoma: diagnostic utility and prognostic significance.Journal of Clínical OncoIogy 1999; 17: 578-584.

Dr  Víctor Moreno Aguado

I González-García, V Moreno, M Navarro, J Martí-Ragué, E Marcuello, C Benasco, O Campos, G Capella, M A. Peinado. Standardized Approach for Microsatellite Instability Detection in Colorectal Carcinomas. Journal of the National Cancer Institute 2000; (abril) (in press).

Dr  Rosanna Paciucci Barzanti

Paciucci R, Tor' M, Dmaz VM, Real FX. h  The plasminogen activator system in pancreas cancer: raje of  t-PA in the invasive potential in vitro. Oncogene 1998; 16(5):625-633. 

Paciuccl , Vila MR, Adell T, Dmaz VM, Tor' M, Nakamura T, Real FX. Activation of u-PA/u-PAR system and redistribution of E-cadherin are associated with HGF-induced motility of pancreas tumor cells overexpressig Met. Am J PathoI1998;153:201-212. 

Paciucci, R, Benedit, P., Thomson, T,. Valeri, M., Nadal,M., C'ceres, C., de Torres, l., Estivill, X., Lozano, J.J., Morote, J. and Reventss,J. PTOV1, a novel protein overexpressed in prostate cancer contains a new class of protein modules. Oncogene 2001; 20: 1455-1464. 

Diaz V M, Planagum' J, Thomson T, Reventss J and Paciucci R. Tissue plasminogen activator is required for the growth, invasion and angiogenesis of pancreatic tumor Cells. Gastroenterology 2002; 122:806-819. 

Batlle E, Verdz J, Dommnguez D, Llosas MM, Dmaz VM, Paciucci R, Alameda F, Garcma de Herreros A. Protein kinase C-alpha activity inversely regulates invasion of growth of intestinal cells. J Biol Chem 1998;273:15091-15098.

Santamarma A Fernandez P, Farri X, Benedit P, Reventss J, Morote J, Thomson TM and Paciucci R. PTOV-1, a novel protein overexpressed in prostate cancer,shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. The American Journal of Pathology (octubre de 2002,en prensa).

Dr  Marçal Pastor i Anglada

Mercader J, Gómez-Angelats M, Del Santo B, Casado J, Felipe A, Pastor-Anglada M. Nucleoside uptake in rat liver parenchymal cells.Biochemical Journal 317:835-842, 1996

Pastor-Anglada M, Casado FJ, Felipe A, Mata FJ, Valdés R, Del Santo B. Sodium Purine nucleoside transporter.Hepatology 29:1337-1338, 1999

Soler C, Felipe A, Casado FJ, Celada A, Pastor-Anglada M. Nitric oxide regulates nucleoside transport in activated B-lymphocytes.Journal of Leukocyte Biology 67:345-349, 2000

Pastor-Anglada M, Felipe A, Casado FJ, Del Santo B, Valdés R, Mata FJ. Nucleoside transporters and liver cell growth.Biochemistry and Cell Biology 76:771-777, 1998 (Invited Review)

Soler C, Felipe A, Mata FJ, Casado FJ, Celada A, Pastor-Anglada M. Regulation of nucleoside transport by lipopolysaccharide, phorbol esters and TNF-a in human B-lymphocytes.Journal of Biological Chemistry 273:26939-26945, 1998

Gómez-Angelats M, Del Santo B, Mercader J, Ferrer-Martínez A, Felipe A, Casado J, Pastor-Anglada M. Hormonal regulation of concentrative nucleoside transport in liver parenchymal cells.Biochemical Journal, 313:915-920, 1996

Pastor-Anglada M, Felipe A, Casado FJ. Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies.Trends in Pharmacological Sciences 19:424-430, 1998 (Invited Review)

Santo B, Valdés R, Mata FJ, Felipe A, Casado FJ, Pastor-Anglada. Differential expression and regulation of nucleoside transport systems in liver parenchymal and hepatoma cells.Del Hepatology 28:1504-1511, 1998

Felipe A, Valdés R, Del Santo B, Lloberas J, Casado FJ, Pastor-Anglada M. Na-dependent nucleoside transport in liver. Two different isoforms from the same gene family are expressed in liver parenchymal cells.Biochemical Journal 330:997-1001, 1998

Felipe A, Ferrer-Martínez A, Casado FJ, Pastor-Anglada M. Expression of the sodium-dependent nucleoside transporter (SPNT) mRNA correlates with nucleoside uptake activity in rat liver.Biochemical Biophysical Research Communications 233:572-575, 1997

Dr  Miquel A. Peinado Morales

Arribas R, Ribas M, Risques MA, Masramón LA, Tórtola S, Marcuello E, Aiza G, Miró R, Capellà G, Peinado MA. Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival.Clinical Cancer Research, 5:3454-3459, 1999.

Tórtola S, Marcuello E, Risques RA, González S, Aiza G, Capellà G, Peinado MA. Overall deregulation in gene expression as a novel indicator of tumor aggressiveness in colorectal cancer.Oncogene, 30:4383-4387, 1999.

Tórtola S, Capella G, Marcuello E, Günther K, Aiza G, Masramon L, Reymond MA, Peinado MA. Analysis of differential gene expression in human colorectal tumor tissues by RNA Arbitrarily Primed PCR: A technical assessment.Laboratory Investigation, 78: 309-317, 1998.

Masramon L, Arribas R, Tórtola S, Perucho M, Peinado MA. Moderate amplifications of the c-myc gene correlate with molecular and clinico-pathological parameters in colorectal cancer.British Journal of Cancer, 77:2349-2356, 1998.

Arribas R, Masramon L, Peinado MA. Application of the arbitrarily primed PCR.The analysis of tumor genetic alterations.Bioforum International 2:77-81, 1998.

Arribas R, Risques RA, González-García I, Masramon L, Aiza G, Ribas M, Capellà G, Peinado MA. Tracking recurrent quantitative genomic alterations in colorectal cancer: Allelic losses in chromosome 4 correlate with tumor aggressiveness.Laboratory Investigation, 79:111-122, 1999.

Masramon I, Risques RA, Arribas R, Peinado MA. Detection and characterization of genetic alterations in tumor cells by Arbitrarily Primed PCR.Lab Medica International, 16:14-17, 1999.

Tórtola S, Marcuello E, González S, Reyes G, Arribas G, Aiza G, Sancho J, Peinado MA, Capellá G. p53 and K-ras mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.Journal of Clinical Oncology, 17: 1375-1381, 1999.

Arribas R, Tórtola S, Welsh J, McClelland M, Peinado MA. Arbitrarily Primed PCR and RAPDs.Fingerprinting Methods Based on PCR, pp 47-53 Ed.: MR Micheli & R. Bova. Springer-Verlag, Berlin Heidelberg, 1997.

Arribas R, Capellà G, Tórtola S, Masramón L, Grizzle W, Perucho M, Peinado MA. Assessment of Genomic Damage in Colorectal Cancer by DNA Fingerprinting: Prognostic Applications.Journal of Clinical Oncology, 15: 3230-3240, 1997.

Palicio M, Blanco I, Tórtola S, González I, Marcuello E, Brunet J, Lluís F, González-Aguilera JJ, Peinado MA, Capellá G. Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer.British Journal of Cancer, 82:535-537, 2000.

Lluís F, González S, Palicio M, Trasserra C, Serrano A, Molina M, Pujol J, Brunet J, Marcuello E, Peinado MA, Obrador A, Andreu M, Capellà G. Bases genéticas de la agregación familiar en el cáncer colorrectal. Poliposis cólica familiar y sindrome de Lynch. Registro de familias y diagnóstico molecular de portadores asintomáticos.Gastro 97. p.127-137. Ed.: Pérez-Piqueras J, Herrerías Gutierrez JM, Arenas Miravé JI, Díaz-Rubio M. ELA, Madrid 1997.

Arribas R, Tórtola S, Welsh J, McClelland M, Peinado MA. Analysis of tumor specific genetic alterations by Arbitrarily Primed PCR. Fingerprinting Methods Based on PCR.p.177-185. Ed.: MR Micheli & R. Bova. Springer-Verlag, Berlin Heidelberg, 1997.

González-García I, Moreno V, Navarro M, Martí-Ragué J, Marcuello E, Benasco C, Campos O, Capellà G, Peinado MA. Standardized approach for microsatellite instability detection in colorectal carcinomas.Journal of the National Cancer Institute, 92:544-549, 2000.

Tarafa G, Villanueva A, Farré L, Rodríguez J, Musulén E, Reyes G, Puig P, Seminago R, Olmedo E, Paules AB, Peinado MA, Bachs O, Capellá G. DCC and smad4 alterations in human colorectal and pancreatic tumor dissemination.Oncogene, 19:546-555, 2000.

Masramon L, Risques RA, Arribas R, Peinado MA. Detection of genetic alterations in tumor cells by Arbitrarily Primed PCR.Biotech Lab International, 4:6-9, 1999.

Arribas R, Capellá G, Perucho M, Peinado MA. Inestabilidad genómica en el cáncer colorrectal.Gastro 97. p.145-152. Ed.: Pérez-Piqueras J,Herrerías Gutierrez JM, Arenas Miravé JI, Díaz-Rubio M. ELA, Madrid 1997

Dr  Ricardo Pérez Tomás

Pérez R. Immunolocalization of Transforming growth factor-alpha and epidermal growth factor-receptor in the rat gastroduodenal area.Digest. Dis. Sciences 44:1408-1416. 1999.

Pérez R. Epidermal growth factor-receptor (EGF-R) localisation in the apical membrane of enerocytes in rat duodenum.Cell Biology International. 23: 475-479. 1999.

Pérez R. Factor de crecimiento transformante-alpha.Bioreguladores. S1 27-32. 1996

Dr  Jaime Prat Díaz de Losada

Matías-Guiu X, Prat J. Molecular Pathology of ovarian cancer.Virchows Arch 1998; 433:103-111.

Esteller M, Catasus Ll, Matías-Guiu X, Mutter G, Prat J, Baylin SB. Herman JG: hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis.Am J Pathol 1999; 155:1767-1772.

Catasús Ll, Machín P, Matías-Guiu X, Prat J. Microsatellite instability in endometrial carcinomas.Clinico-pathologic correlations in a series of 42 cases.Hum Pathol 1998; 29:1160-1164.

Esteller M, Silva JM, Domínguez G, Bonilla F, Matías-Guiu X, Lerma E, Prat J, Harkes I, Repasky EA, Gabrielson E, Schutte M, Baylin SB, Herman JG. Promoter hypermethylation is a cause of BRAC1 inactivation in sporadic breast and ovarian tumors.J Natl Cancer Inst 2000; 92:564-569. 

García A, Busaglia E, Machín P, Matías-Guiu X, Prat J. Loss of heterozygosity on chromosome 17q in epithelial ovarian tumors: Association with carcinomas with serous differentiation.Int J Gynecol Pathol 2000; 19:152-157. .

Prat J. Loss of heterozygosity at fue RB-l locus and pRB immunostaining in epithelial ovarian tumors: a molecular, immunohistochemical, and clinicopathologic study. International Journal of Gynecological Pathology 2001; 20:335-340 

Prat J. Microsatellite instability, MLH-l promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors. Cancer 2001; 92:2829-2836

Dr  Francesca Rivera Filat

Oriola J, Titos E, Leivas A, Navarro MA, Rivera-Fillat F. Short report on DNA markers at candidate loci. Two new polymorphisms in the BRCA 1 gene.Clinical Genetics 51:361-362. 1997

Dr  Sílvia de Sanjosé Llongueras

Dr  Àngels Sierra Jiménez

Sierra A, Castellsagué X, Coll T y col. Expression of death-related genes and their relationship with loss of apoptosis in T1 ductal breast carcinomas.Int. J. Cancer, 79: 103-110, 1998

Moreno A, Lloveras B, Figueras A, Escobedo A, Ramón JM, Sierra A, Fabra A. Ductal carcinoma in situ of the breast: Correlation between histologic classifications and biologic markers.Modern Pathology, 10:1088-1092

Sierra A, Fabra A, Llorens A, González M y col. Astrocites-derived cytokines contribute to the metastatic brain specificity of breast cancer cells.Laboratory Investigation, 77:357-367, 1997

Sierra A, Castellsagué X, Escobedo A y col. Synergistic cooperation between c-Myc and Bcl-2 in lymph node progression of T1 breast carcinomas.Breast Cancer Research & Treatment, 54: 39-45

Dr  Manuel Trias Folch

JK Wiencke, Zheng S, Lafuente A, Lafuente MJ, Grudzen C, Wrensch MR, Miike R, Ballesta A, Trias M. Aberrant Methylation of p16 INK4a, in anatomic and gender-specific subtypes of sporadic colorectal cancer.Cancer Epi. Biom & Prev., 8 1999 501-506.

Zheng S, Wiencke JK, Chen P, Lafuente A, Lafuente MJ, Grudzen C, Ballesta A, Trias M. Detection of p19ARF methylationmin human colon cancer cell lines.Proceed Am Assoc Cancer Res 40, pp 441, 1999.

Lafuente MJ, Casterad X, Trias M, Ascao C, Molina R, Ballesta A, Zheng S, Wiencke JK, Lafuente A. NAD(P)H:quinonee oxidoreductase (NQ01)-dependent risk for colorectal cancer and its association with the presence of K-RAS mutations in tumors Carcinogenesis.2000 Volume 21/08-21

Zheng S, Lafuente A, Grudzen C, Lafuente MJ, Ballesta A, Trias M, Wiencke JK. Methylenetetrahydrofolate reductase (MTHFR) activity in colorectal cancer. Lack of association with K-ras mutation.Cancer Res, 1998; 39: 628.

N. Laso, M.J. Lafuente , S. Mas , M. Trias , C. Ascaso , R. Molina , A. Ballesta, F. Rodríguez and A. Lafuente..Glutathione S-transferase (GSTMl and GSTT1)-dependent Risk for Colorectal Cancer. Anticancer research 22: 3399-3404 (2002)

S Zheng, P Chen, A McMillan, A Lafuente, MJ Lafuente, A Ballesta, M Trias and JK. Wiencke. Correlations of partial and extensive rnethylation at the p14ARF locos with reduced rnRNA expression in colorectal cancer cell liDes and clinicopathological features in prirnary turnors. Carcinogenesis vol.21 no.ll pp.2057-2064, 2000

Dr  Francesc Villarroya Gombau

Villena JA, Vinas O, Mampel T, Iglesias R, Giralt M, Villarroya F. Regulation of mitochondrial biogenesis in brown adipose tissue: nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase.(subunit Biochenr. J. (1998) 331, 121-127 (Printed in Great Britain)

Dr  Núria Viñolas Segarra

Galán MC, Viñolas, N, Colomer D, Soler G, Muñoz M, Grau JJ, Estapé J. Detección de la enfermdad subclínica en cáncer de mama localizado, mediante la reacción en cadena de la polimerasa - Resultados preliminares.Neoplasia 14:170-174,1997

Dr  Jordi Vives Puiggrós

Vigorito E, Plaza S, Mir L, Mongay L, Viñas O, Serra-Pagés C, Vives J. Contributions of p53 and PMA to (-irradiation induced apoptosis in Jurkat cells.Hematol Cell Ther 41:153-161, 1999